Results 11 to 20 of about 7,940 (198)

Lats1/2 Differentially Modulate the Proliferative State of Dental Epithelial Progenitors and Ameloblasts in the Murine Incisor. [PDF]

Orthod Craniofac Res
ABSTRACT Objective(s) Yes‐Associated Protein (YAP) is a critical regulator of cell proliferation and differentiation, having the capacity to convert differentiated cells into somatic stem cells in several contexts. Here we investigate the plasticity of adult mouse dental epithelial cells by testing the effects of ectopic YAP activation in dental ...
Zhang Z, Upadhyay S, Luong C, Du W, Hu JK.   +4 more
europepmc   +2 more sources

Impression of the Clock Genes on Oral Health and Diseases: A Narrative Review [PDF]

Journal of Clinical and Diagnostic Research, 2023
The circadian clock helps organisms adapt their physiological processes to changing environmental conditions, including the adaptation of the 24-hour sleep-wake cycle in day and night. Circadian rhythms regulate the proper timing and synchronisation of
Amol Dhokar, Heena Golani, Latisha Prashant Hadkar   +2 more
doaj   +1 more source

Na+ and K+ transport and maturation stage ameloblast modulation

Frontiers in Physiology, 2023
Introduction: Enamel mineralization requires calcium transport into the extracellular matrix for the synthesis of hydroxyapatite (HA) crystals. Formation of HA releases protons into the matrix, which are then neutralized when ameloblasts modulate from ...
Jake Ngu, Antonius L. J. J. Bronckers, Kaitlin Katsura, Yan Zhang, Pamela K. Den Besten   +4 more
doaj   +1 more source

Fluorosed mouse ameloblasts have increased SATB1 retention and Gαq activity. [PDF]

PLoS ONE, 2014
Dental fluorosis is characterized by subsurface hypomineralization and increased porosity of enamel, associated with a delay in the removal of enamel matrix proteins.
Yan Zhang, Ji-Yeon Kim, Orapin Horst, Yukiko Nakano, Li Zhu, Ralf J Radlanski, Sunita Ho, Pamela K Den Besten   +7 more
doaj   +1 more source

Single-Cell RNA-Sequencing From Mouse Incisor Reveals Dental Epithelial Cell-Type Specific Genes

Frontiers in Cell and Developmental Biology, 2020
Dental epithelial stem cells give rise to four types of dental epithelial cells: inner enamel epithelium (IEE), outer enamel epithelium (OEE), stratum intermedium (SI), and stellate reticulum (SR).
Yuta Chiba, Kan Saito, Daniel Martin, Erich T. Boger, Craig Rhodes, Keigo Yoshizaki, Takashi Nakamura, Aya Yamada, Robert J. Morell, Yoshihiko Yamada, Satoshi Fukumoto, Satoshi Fukumoto   +11 more
doaj   +1 more source

The Unfolded Protein Response in Amelogenesis and Enamel Pathologies [PDF]

, 2017
During the secretory phase of their life-cycle, ameloblasts are highly specialized secretory cells whose role is to elaborate an extracellular matrix that ultimately confers both form and function to dental enamel, the most highly mineralized of all ...
Barron, Bartlett, Basseri, Brookes, Brookes, Brookes, Brookes, Chen, Chlubek, Coelho, Credle, Den Besten, Denny, Dey, DiGiuseppe, Dobson, Eletto, Fava, Fribley, Galvan, Gardner, Gonzales, Gregersen, Han, Harding, Hassunuma, Hetz, Hetz, Hetz, Hollien, Hu, Inkielewicz-Stepniak, Iwasaki, Joseph, Joseph, Joseph, Kim, Kimata, Kopito, Kubota, Lacruz, Lakshminarayanan, Lee, Li, Li, Lin, Malhotra, Malhotra, Matsuo, Melchior, Moore, Moore, Moradian-Oldak, Moukdar, Nishio, Nomura, Novosyadlyy, Oakes, Ow, Ozcan, Paine, Prischi, Puthalakath, Reith, Ron, Rutkowski, Ryu, Santos, Schonthal, Schroder, Schubert, Selkoe, Sharma, Sharma, Sire, Smith, Smith, Smith, Smith, Su, Suzuki, Suzuki, Tabas, Tanabe, Teske, Tsuchiya, Tsuru, Tye, Upton, Valastyan, Vilatoba, Wang, Wei, Wu, Yam, Yoshida, Yue, Zhu, Zode   +98 more
core   +9 more sources

Calcium Transport in Specialized Dental Epithelia and Its Modulation by Fluoride

Frontiers in Endocrinology, 2021
Most cells use calcium (Ca2+) as a second messenger to convey signals that affect a multitude of biological processes. The ability of Ca2+ to bind to proteins to alter their charge and conformation is essential to achieve its signaling role.
Veronica Costiniti, Guilherme H. Bomfim, Erna Mitaishvili, Ga-Yeon Son, Yi Li, Rodrigo S. Lacruz   +5 more
doaj   +1 more source

Targeted p120-catenin ablation disrupts dental enamel development. [PDF]

PLoS ONE, 2010
Dental enamel development occurs in stages. The ameloblast cell layer is adjacent to, and is responsible for, enamel formation. When rodent pre-ameloblasts become tall columnar secretory-stage ameloblasts, they secrete enamel matrix proteins, and the ...
John D Bartlett, Justine M Dobeck, Coralee E Tye, Mirna Perez-Moreno, Nicole Stokes, Albert B Reynolds, Elaine Fuchs, Ziedonis Skobe   +7 more
doaj   +1 more source

Mobility gene expression differences among wild-type, Mmp20 null and Mmp20 over-expresser mice plus visualization of 3D mouse ameloblast directional movement

Scientific Reports, 2023
Enamel forming ameloblasts move away from the dentino-enamel junction and also move relative to each other to establish enamel shape during the secretory stage of enamel development.
Masashi Shin, Aya Matsushima, Jun-ichi Nagao, Yoshihiko Tanaka, Hidemitsu Harada, Koji Okabe, John D. Bartlett   +6 more
doaj   +1 more source

The hidden depths of zebrafish skin

eLife, 2023
Single-cell transcriptome analysis of zebrafish cells clarifies the signalling pathways controlling skin formation and reveals that some cells produce proteins required for human teeth to acquire their enamel.
Yue Rong Tan, Megan Liaw, Chen-Hui Chen
doaj   +1 more source