Results 91 to 100 of about 10,073 (196)

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source

Bacterio-plankton transformation of diazepam and 2-amino-5-chlorobenzophenone in river waters. [PDF]

, 2014
Benzodiazepines are a large class of commonly-prescribed drugs used to treat a variety of clinical disorders. They have been shown to produce ecological effects at environmental concentrations, making understanding their fate in aquatic environments very
Ainsworth, Bianchi, Boxall, Brodin, Brooks, Calisto, Calisto, Cole, Crump, Diaz-Cruz, Gardolinski, Griffiths, Guenet, Halling-Sørensen, Helbling, Holmes, Ibekwe, Kan, Kosjek, Kümmerer, Lane, Liu, Loffler, Muyzer, Muyzer, Nercessian, Onesios-Barry, Porter, Shimp, Straub, Stuer-Lauridsen, Suzuki, Tappin, Tappin, Ternes, Verlicchi, West, WHO, Yoon, Zuccato   +39 more
core   +3 more sources

Expression, purification and characterisation of recombinant peptide:N-glycosidase F. : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Biochemistry at Massey University [PDF]

, 2000
PNGase F (Peptide-N4-(N-acetyl-D-glucosaminyl) asparagine amidase F) is an amidohydrolase isolated from the extracellular medium of the Gram-negative bacterium Flavobacterium meningosepticum.
Loo, Trevor Stephen
core  

Crystal structure of Methanococcus jannaschii dihydroorotase with substrate bound

Acta Crystallographica Section F, Volume 82, Issue 1, Page 23-31, January 2026.
We present the 1.87 Å resolution structure of M. jannaschii dihydroorotase complexed with the substrate carbamoyl aspartate at room temperature. Contrary to expectations, a flexible loop which is important in catalysis and closes upon substrate binding in order to stabilize the substrate and transition state is observed in both the loop‐out and loop‐in
Jacqueline Vitali, Jay C. Nix, Haley E. Newman, Michael J. Colaneri   +3 more
wiley   +1 more source

Folate Interaction With Genetic Risk for Neural Tube Defects Among Infants in Bangladesh

Birth Defects Research, Volume 117, Issue 12, December 2025.
ABSTRACT Background Neural tube defects such as spina bifida (SB) are congenital anomalies associated with significant morbidity and mortality worldwide. Environmental factors, particularly folate, modify SB risk. Based on recurrence rates of SB within families, genetic risk also contributes to SB development.
Enrique Mondragon‐Estrada, Xingyan Wang, Michael D. Uhler, Afifah Farooque, Kelly Liu, Sudipta Kumer Mukherjee, Sheikh Muhammad Ekramullah, D. M. Arman, Joynul Islam, Hafiza Sultana Suchanda, David C. Christiani, Benjamin C. Warf, Maitreyi Mazumdar, Sarah U. Morton   +13 more
wiley   +1 more source

LncR-GAS5 decrease in adenine phosphoribosyltransferase expresssion via binding TAF1 to increase kidney damage created by CIH

Heliyon
Objective: Chronic kidney disease (CKD) related to obstructive sleep apnea-hypopnea syndrome (OSAHS) mainly results from chronic intermittent hypoxia (CIH)-induced renal injury.
Wei Liu, Wukaiyang Liang, CunTai Zhang, Huiguo Liu, Hai Li, Lun Zhou, Ling Zhou   +6 more
doaj   +1 more source

Exploration of Human Skin Phageome to Reveal Endolysins and Novel Antimicrobial Peptides for Therapeutic Applications

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
This study uncovers diverse endolysins and novel antimicrobial peptides from the human skin phageome, highlighting their potential to target antibiotic‐resistant pathogens and disrupt virulence mechanisms, paving the way for next‐generation skin therapeutics.
Jibon Kumar Paul, Arzuba Akter, Nurnabi Azad Jewel, Mohimenul Haque Rolin, Daniyal Karim, Raphael Kabir Niloy, Shakhinur Islam Mondal   +6 more
wiley   +1 more source

Properties of rat liver N-acylethanolamine amidohydrolase.

Journal of Biological Chemistry, 1985
Rat liver microsomes and mitochondria contain an amidohydrolase which catalyzes the hydrolysis of N-acylethanolamine to ethanolamine and fatty acid. The enzyme is active over a wide range of pH, does not require divalent cations, and is inhibited by sulfhydryl-reactive agents.
P C, Schmid, M L, Zuzarte-Augustin, H H, Schmid   +2 more
openaire   +2 more sources

Overexpression and knockdown of cotton GhdadD gene reveals its drought and salt stress tolerance role

iScience
Summary: The 5′-deoxyadenosine deaminase (DADD), a member of the amidohydrolase family regulates biological purine metabolism. In this study, bioinformatic analysis, overexpression and knockdown of GhdadD gene were detected to identify its potential role
Yuanyuan Zhang, Jie Zheng, Shiraku Margaret Linyerera, Richard Odongo Magwanga, Yuqing Hou, Yuhong Wang, Yanchao Xu, Aziz Khan, Shuxun Yu, Zhongli Zhou, Fang Liu, Xiaoyan Cai   +11 more
doaj   +1 more source

Identification of a candidate gene for a QTL for spikelet number per spike on wheat chromosome arm 7AL by high-resolution genetic mapping. [PDF]

, 2019
Key messageA high-resolution genetic map combined with haplotype analyses identified a wheat ortholog of rice gene APO1 as the best candidate gene for a 7AL locus affecting spikelet number per spike.
Akhunov, Eduard, Anderson, James A, Bai, Guihua, Brown-Guedira, Gina, DeWitt, Noah, Dubcovsky, Jorge, Faris, Justin D, Fraser, Max, Katz, Andrew, Kuzay, Saarah, Pearce, Stephen, Peters Haugrud, Amanda, Su, Zhenqi, Xu, Yunfeng, Zhang, Junli   +14 more
core   +1 more source