Results 101 to 110 of about 4,894 (170)

Genetic diversity of Leptospira in northwestern Colombia: first report of Leptospira santarosai as a recognised leptospirosis agent

Memorias do Instituto Oswaldo Cruz
The region of Antioquia in northeastern Colombia has the highest number of reported leptospirosis cases in the country. It also shows high seroprevalence indexes in the general population and socio-environmental conditions favourable for the transmission
Ronald Guillermo Peláez Sanchez, Juan Álvaro Lopez, Martha María Pereira, Margarita Arboleda Naranjo, Piedad Agudelo-Flórez   +4 more
doaj   +1 more source

Structural Basis for pH-Dependent Oligomerization of Dihydropyrimidinase from Pseudomonas aeruginosa PAO1

Bioinorganic Chemistry and Applications, 2018
Dihydropyrimidinase, a dimetalloenzyme containing a carboxylated lysine within the active site, is a member of the cyclic amidohydrolase family, which also includes allantoinase, dihydroorotase, hydantoinase, and imidase.
Jen-Hao Cheng, Chien-Chih Huang, Yen-Hua Huang, Cheng-Yang Huang   +3 more
doaj   +1 more source

ASAH1 facilitates TNBC by DUSP5 suppression-driven activation of MAP kinase pathway and represents a therapeutic vulnerability

Cell Death and Disease
Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is prone to metastasis and therapy resistance. Owing to its aggressive nature and limited availability of targeted therapies, TNBC is associated with higher mortality as compared to ...
Kiran Kumar Reddi, Suresh Chava, Siva Chander Chabattula, Yvonne J. K. Edwards, Kamaljeet Singh, Romi Gupta   +5 more
doaj   +1 more source

A New Strategy to Inhibit Scar Formation by Accelerating Normal Healing Using Silicate Bioactive Materials

Advanced Science
Inspired by the scar‐free wound healing in infants, an anti‐scar strategy is proposed by accelerating wound healing using silicate bioactive materials.
Zhaowenbin Zhang, Chen Fan, Qing Xu, Feng Guo, Wenbo Li, Zhen Zeng, Yuze Xu, Jing Yu, Hongping Ge, Chen Yang, Jiang Chang   +10 more
doaj   +1 more source

Exploring the Effect and Molecular Docking Interaction of Carboxypeptidase and Amidohydrolase on Ochratoxin A and Zearalenone Degradation

BioResources
To keep consumers from the hazard of exposure to mycotoxins and meet the allowed limits, numerous physical and chemical approaches for eliminating Ochratoxin A (OTA) and Zearalenone (ZEN) have been studied.
Sulaiman A. Alsalamah, Mohammed Ibrahim Alghonaim, Abdu Ali Y. Moafa, Mukul Sharma   +3 more
doaj  

Probing the enzymatic activity and maturation process of the EcAIII Ntn-amidohydrolase using local random mutagenesis

Acta Biochimica Polonica
This report describes a comprehensive approach to local random mutagenesis of the E. coli Ntn-amidohydrolase EcAIII, and supplements the results published earlier for the randomization series RDM1.
Joanna I. Loch, Anna Ściuk, Anna Ściuk, Marta Kilichowska, Marta Kilichowska, Izabela Pieróg, Izabela Pieróg, Weronika Łukaszczyk, Katarzyna Zimowska, Mariusz Jaskolski, Mariusz Jaskolski   +10 more
doaj   +1 more source

Safety evaluation of the food enzyme glutaminase from the non‐genetically modified Bacillus amyloliquefaciens strain AE‐GT

EFSA Journal
The food enzyme glutaminase (l‐glutamine amidohydrolase; EC 3.5.1.2) is produced with the non‐genetically modified Bacillus amyloliquefaciens strain AE‐GT by Amano Enzyme Inc.
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Vittorio Silano, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Claude Lambré, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger‐Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Magdalena Andryszkiewicz, Daniele Cavanna, Yi Liu, Simone Lunardi, Elsa Nielsen, Karin Norby, Giulio diPiazza, Yrjö Roos, Andrew Chesson   +26 more
doaj   +1 more source

Metarhizium spp. encode an ochratoxin cluster and a high efficiency ochratoxin-degrading amidohydrolase revealed by genomic analysis

Journal of Advanced Research
Introduction: Ochratoxins (OTs) are worldwide regulated mycotoxins contaminating a variety of food-environment and agro-environment. Several Aspergillus and Pencillium species synthesize OTs from a six-gene biosynthetic gene cluster (BGC) to produce the ...
Gang Wang, Wenqing Wu, Nancy P. Keller, Xu Guo, Erfeng Li, Junning Ma, Fuguo Xing   +6 more
doaj   +1 more source

A user-friendly CRISPR/Cas9 system for mutagenesis of Neurospora crassa

Scientific Reports
As a widely used eukaryotic model organism, Neurospora crassa offers advantages in genetic studies due to its diverse biology and rapid growth. Traditional genetic manipulation methods, such as homologous recombination, require a considerable amount of ...
Stefanie Grüttner, Frank Kempken
doaj   +1 more source

Safety evaluation of the food enzyme asparaginase from the non‐genetically modified Saccharomyces cerevisiae strain ARY‐2

EFSA Journal
The asparaginase (L‐asparagine amidohydrolase, EC 3.5.1.1) is produced by the non‐genetically modified Saccharomyces cerevisiae strain ARY‐2 by Renaissance BioScience Corporation.
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Henk Van Loveren, Laurence Vernis, Cristina Fernàndez‐Fraguas, Daniele Cavanna, Silvia Peluso, Yi Liu   +16 more
doaj   +1 more source