Results 131 to 140 of about 4,894 (170)
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Anandamide amidohydrolase (fatty acid amide hydrolase)
Prostaglandins & Other Lipid Mediators, 2000Anandamide (N-arachidonoylethanolamine) loses its cannabimimetic activity when it is hydrolyzed to arachidonic acid and ethanolamine by the catalysis of an enzyme referred to as anandamide amidohydrolase or fatty acid amide hydrolase. Cravatt's group and our group cloned cDNA of the enzyme from rat, human, mouse and pig, and the primary structures ...
N, Ueda, S, Yamamoto
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Structural and Catalytic Diversity within the Amidohydrolase Superfamily
Biochemistry, 2005The amidohydrolase superfamily comprises a remarkable set of enzymes that catalyze the hydrolysis of a wide range of substrates bearing amide or ester functional groups at carbon and phosphorus centers. The most salient structural landmark for this family of hydrolytic enzymes is a mononuclear or binuclear metal center embedded within the confines of a
Clara M, Seibert, Frank M, Raushel
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Purification and Characterization of Allantoate Amidohydrolase fromBacillus fastidiosus
Archives of Biochemistry and Biophysics, 1995Allantoate amidohydrolase from Bacillus fastidiosus was purified 170-fold to homogeneity as judged by isoelectric focusing and nondenaturing and sodium dodecyl sulfate polyacrylamide gel electrophoresis. The molecular mass was estimated to be 128 kDa. The enzyme appeared to be a homodimer with a subunit molecular mass of 66 kDa.
Xu, Z.W. +2 more
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Novel Inhibitors of Brain, Neuronal, and Basophilic Anandamide Amidohydrolase
Biochemical and Biophysical Research Communications, 1997Mammalian brain as well as mouse neuroblastoma (N18TG2) and rat basophilic leukaemia (RBL) cells were previously shown to contain "anandamide amidohydrolase', a membrane-bound enzyme sensitive to serine and cysteine protease inhibitors and catalyzing the hydrolysis of the endogenous cannabimimetic metabolite, anandamide (arachidonoyl-ethanolamide ...
De Petrocellis L +7 more
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Response of amidohydrolases in soils to chloroform fumigation
Journal of Plant Nutrition and Soil Science, 2002An ongoing challenge in enzymology is the differentiation between the various pools of enzymes in soils, i.e. between accumulated (extracellular) enzymes and enzymes associated with the microbial biomass (intracellular enzymes). In order to solve this problem, 10 surface soils representing a wide range of physico-chemical properties and purified ...
Susanne Klose, M. Ali Tabatabai
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Amidohydrolases in soils as affected by cropping systems
Applied Soil Ecology, 2003Cropping systems influence the ecology of agricultural soils. The effects of crop rotation and N fertilization on the activities of four amidohydrolases (amidase, l-asparaginase, l-aspartase, and l-glutaminase) were studied in soils of two long-term cropping systems in Iowa: the Northeast Research Center (NERC) and the Clarion–Webster Research Center ...
D.E Dodor, M.A Tabatabai
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Inhibition of Serine Amidohydrolases by Complexes of Vanadate with Hydroxamic Acids
Biochemical and Biophysical Research Communications, 2000Serine beta-lactamases are inhibited by phosphonate monoester monoanions. These compounds phosphonylate the active site serine hydroxyl group to form inert, covalent complexes. Since spontaneous hydrolysis of these phosphonates is generally quite slow, the beta-lactamase active site must have considerable affinity for the (presumably) pentacoordinated ...
J H, Bell, K, Curley, R F, Pratt
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Evolutionary relationship and application of a superfamily of cyclic amidohydrolase enzymes
The Chemical Record, 2005AbstractCyclic amidohydrolases belong to a superfamily of enzymes that catalyze the hydrolysis of cyclic CN bonds. They are commonly found in nucleotide metabolism of purine and pyrimidine. These enzymes share similar catalytic mechanisms and show considerable structural homologies, suggesting that they might have evolved from a common ancestral ...
Nam, SH Nam, Sung-Hun +2 more
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Penicillin amidohydrolase productivity of locally isolated bacterial species
Folia Microbiologica, 1991Penicillin amidohydrolase productivity of four locally isolated bacterial species is described. Organisms were identified as Escherichia coli, Pseudomonas aeruginosa, Sarcina lutea and Bacillus megaterium. Highest enzyme productivity of 3.2 U/mL with a corresponding dry cell mass of 4.5 g/L was recorded from S. lutea.
Z A, Mahmood, D, Shaikh, S M, Zoha
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Identification of Caerulomycin A Gene Cluster Implicates a Tailoring Amidohydrolase
Organic Letters, 2012The biosynthetic gene cluster for caerulomycin A (1) was cloned and characterized from the marine actinomycete Actinoalloteichus cyanogriseus WH1-2216-6, which revealed an unusual hybrid polyketide synthase (PKS)/nonribosomal peptide synthetase (NRPS) system.
Yiguang, Zhu +8 more
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