Results 51 to 60 of about 10,073 (196)
Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes
Epilepsia Open, EarlyView.Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola +3 more
wiley +1 more source
Frontiers in ChemistryL-Asparaginases, divided into three structural Classes, catalyze the hydrolysis of L-asparagine to L-aspartic acid and ammonia. The members of Class 3, ReAIV and ReAV, encoded in the genome of the nitrogen fixing Rhizobium etli, have the same fold ...
Joanna Sliwiak +6 more
doaj +1 more source
Mechanisms of metal-dependent non-redox decarboxylases from quantum chemical calculations
Computational and Structural Biotechnology Journal, 2021 Quantum chemical calculations are today an extremely valuable tool for studying enzymatic reaction mechanisms. In this mini-review, we summarize our recent work on several metal-dependent decarboxylases, where we used the so-called cluster approach to ...
Xiang Sheng, Fahmi Himo
doaj +1 more source
, 2016 The Dali server (http://ekhidna2.biocenter.helsinki.fi/dali) is a network service for comparing protein structures in 3D. In favourable cases, comparing 3D structures may reveal biologically interesting similarities that are not detectable by comparing ...
Holm, Liisa, Laakso, Laura M.
core +2 more sources
The Hemoprotein Hhy1 Promotes Heme‐Dependent Catalase Activity of Ctt1
Molecular Microbiology, EarlyView.A Schizosaccharomyces pombe strain deficient in heme (hem1Δ) and siderophore (Fc) biosynthesis, as well as high‐affinity iron (Fe) uptake (blue), was used to uncover the hemoprotein Hhy1 that promotes the heme‐dependent activity of the catalase Ctt1. In contrast, hhy1Δ cells exhibit reduced Ctt1 activity and increased sensitivity to oxidative stress ...
Tobias Vahsen +3 more
wiley +1 more source
Studies on racemic triglycerides as urease enzyme inhibitors
Bangladesh Journal of PharmacologyAmidohydrolase enzymes regulate key pathways, and their dysregulation is linked to infection, immune imbalance, and metabolic dysregulation in cancer. Current inhibitors have issues of cost, environmental persistence, and toxicity.
Hamdullah Khadim Sheikh +4 more
doaj +1 more source
Nicotinatfermentation in Eubacterium barkeri [PDF]
, 2005 Aus EcoRI- und BamHI/BglII-Phagen-Genbänken von Eubacterium barkeri wurde mit Hilfe Digoxigenin-markierten homologen DNA-Sonden, direkter genomischer Sequenzierung und Seegene Speedwalking ein Gencluster von 23 kbp kloniert, das für die Enzyme der ...
Al Hapel, Ashraf, Buckel, W. (Prof. Dr.)
core +1 more source
ACS Infectious Diseases, 2016 Photopharmacological agents exhibit light-dependent biological activity and may have potential in the development of new antimicrobial agents/modalities. Amidohydrolase enzymes homologous to the well-known human histone deacetylases (HDACs) are present in bacteria, including resistant organisms responsible for a significant number of hospital-acquired ...
Weston, CE +6 more
openaire +5 more sources
Plant Biotechnology Journal, EarlyView.BAHD acyltransferases drive metabolic diversification in plants by coupling conserved catalytic scaffolds with regulatory flexibility, enabling stress adaptation and ecological specialisation. ABSTRACT BAHD acyltransferases constitute one of the most versatile enzyme superfamilies in plants, catalysing the acylation of alcohols, amines, polyamines, and
Muhammad Mubashar Zafar +7 more
wiley +1 more source
Molecules, 2021 Dihydroorotase (DHOase), a dimetalloenzyme containing a carbamylated lysine within the active site, is a member of the cyclic amidohydrolase family, which also includes allantoinase (ALLase), dihydropyrimidinase (DHPase), hydantoinase, and imidase ...
Hong-Hsiang Guan +4 more
doaj +1 more source