Results 61 to 70 of about 4,894 (170)

Determination of cephalosporin-C amidohydrolase activity with fluorescamine

Journal of Pharmacy and Pharmacology, 1989
Abstract A spectrophotometric procedure for the assay of cephalosporin-C amidohydrolase activity, based on the determination of the 7-aminocephalosporanic acid (7-ACA) produced in the hydrolysis of cephalosporin-C by the enzyme, is described. This procedure can be used to detect 7-ACA over a range of 10 to 200 μg mL−1.
F, Reyes, M J, Martinez, J, Soliveri
openaire   +2 more sources

Safety evaluation of the food enzyme glutaminase from the genetically modified Bacillus subtilis strain Glu3‐3

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract The food enzyme glutaminase (l‐glutamine amidohydrolase; EC 3.5.1.2) is produced with the genetically modified Bacillus subtilis strain Glu3‐3 by Angel Yeast Co., Ltd. The production strain of the food enzyme contains multiple copies of acquired antimicrobial resistance genes.
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Henk Van Loveren, Laurence Vernis, Jaime Aguilera, Magdalena Andryszkiewicz, Daniele Cavanna, Yi Liu   +16 more
wiley   +1 more source

Characterization of the gene cluster involved in allantoate catabolism and its transcriptional regulation by the RpiR-type repressor HpxU in Klebsiella pneumoniae [PDF]

, 2013
Bacteria, fungi, and plants have metabolic pathways for the utilization of nitrogen present in purine bases. In Klebsiella pneumoniae, the genes responsible for the assimilation of purine ring nitrogen are distributed in three separated clusters.
Evangelina Campos, Josefa Badia, Juan Aguilar, Karla Guzmán, Laura Aguilera, Laura Baldoma, Lorena Toloza, Rosa Giménez   +7 more
core   +1 more source

Biopharmaceuticals for Cancer Treatment: An Update

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Cancer is one of the most debilitating diseases, causing profound physical and psychological impacts on patients. The global number of cancer patients has been steadily rising over the last few decades. The development of effective cancer therapies remains the primary focus in life science research, requiring a precise understanding of ...
Anupom Deb Nath, Yousuf Alam, Afsana Mustak Mim, Maksuda Akter, Mohammad Abbas Gani, Khondaker Muhammad Khairul Alam, Md. Nur Alam   +6 more
wiley   +1 more source

Genome-Guided Identification of an OTA-Degrading Amidohydrolase AMH2102 from Acinetobacter kookii AK4 with Enhanced Soluble Expression in Escherichia coli

Toxins
Ochratoxin A (OTA) is a globally distributed mycotoxin that poses serious threats to food safety and human health due to its nephrotoxic, hepatotoxic, and carcinogenic properties. Previous enzymatic detoxification strategies for OTA have been constrained
Zehui Niu, Shengyue Bai, Yuyun Xiao, Jingran Lai, Yuxin Jin, Zitong Zhao, Yan Yang, Shujuan Cun, Zhihong Liang   +8 more
doaj   +1 more source

Crystal structure of human protein N-terminal glutamine amidohydrolase, an initial component of the N-end rule pathway. [PDF]

PLoS ONE, 2014
The N-end rule states that half-life of protein is determined by their N-terminal amino acid residue. N-terminal glutamine amidohydrolase (Ntaq) converts N-terminal glutamine to glutamate by eliminating the amine group and plays an essential role in the ...
Mi Seul Park, Eduard Bitto, Kyung Rok Kim, Craig A Bingman, Mitchell D Miller, Hyun-Jung Kim, Byung Woo Han, George N Phillips   +7 more
doaj   +1 more source

A NIR fluorescent probe for Vanin-1 and its applications in imaging, kidney injury diagnosis, and the development of inhibitor

Acta Pharmaceutica Sinica B, 2022
Vanin-1 is an amidohydrolase that catalyses the conversion of pantetheine into the amino-thiol cysteamine and pantothenic acid (coenzyme A precursor), which plays a vital role in multiple physiological and pathological processes. In this study, an enzyme-
Zhenhao Tian, Fei Yan, Xiangge Tian, Lei Feng, Jingnan Cui, Sa Deng, Baojing Zhang, Tian Xie, Shanshan Huang, Xiaochi Ma   +9 more
doaj   +1 more source

Purification and properties of formylglutamate amidohydrolase from Pseudomonas putida [PDF]

Journal of Bacteriology, 1987
Formylglutamate amidohydrolase (FGase) catalyzes the terminal reaction in the five-step pathway for histidine utilization in Pseudomonas putida. By this action, N-formyl-L-glutamate (FG) is hydrolyzed to produce L-glutamate plus formate. Urocanate, the first product in the pathway, induced all five enzymes, but FG was able to induce FGase alone ...
L, Hu, L M, Mulfinger, A T, Phillips
openaire   +2 more sources

The gut microbiome promotes the growth performance of black soldier fly larvae by detoxifying uric acid

iMetaOmics, Volume 3, Issue 1, March 2026.
This study demonstrates the detrimental effects of exogenous uric acid (UA) on the growth of black soldier fly (BSF) larvae, highlighting the role of gut microbiota in UA degradation. We isolated UA‐degrading bacterial strains associated with BSF, including Enterococcus faecalis AHAU24.
Xiaowen Ji, Shaojie Zhou, Wenwen Chen, Bin Cao, Jingjing Zhuang, Sheng Zhang, Bingshuo Han, Benping Yang, Shuxiang Zhang, Yanfeng Xue, Jibin Zhang, Yinglao Zhang, Wei Liu   +12 more
wiley   +1 more source

A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis

eLife, 2017
The N-end rule pathway is an evolutionarily conserved proteolytic system that degrades proteins containing N-terminal degradation signals called N-degrons, and has emerged as a key regulator of various processes.
Zhaowei Wang, Xiaoling Xia, Xueli Yang, Xueyi Zhang, Yongxiang Liu, Di Wu, Yuan Fang, Yujie Liu, Jiuyue Xu, Yang Qiu, Xi Zhou   +10 more
doaj   +1 more source