Results 51 to 60 of about 4,894 (170)

The BAHD Acyltransferase Gene Family: Evolutionary Dynamics, Biochemical Mechanisms, and Roles in Plant Stress Adaptation

Plant Biotechnology Journal, EarlyView.
BAHD acyltransferases drive metabolic diversification in plants by coupling conserved catalytic scaffolds with regulatory flexibility, enabling stress adaptation and ecological specialisation. ABSTRACT BAHD acyltransferases constitute one of the most versatile enzyme superfamilies in plants, catalysing the acylation of alcohols, amines, polyamines, and
Muhammad Mubashar Zafar, Qiao Fei, Abdul Razzaq, Ayesha Siddiqua, Ayesha Naveed, M. Nasir Khan, Huma Saleem, Xuefei Jiang   +7 more
wiley   +1 more source

Structural Analysis of Saccharomyces cerevisiae Dihydroorotase Reveals Molecular Insights into the Tetramerization Mechanism

Molecules, 2021
Dihydroorotase (DHOase), a dimetalloenzyme containing a carbamylated lysine within the active site, is a member of the cyclic amidohydrolase family, which also includes allantoinase (ALLase), dihydropyrimidinase (DHPase), hydantoinase, and imidase ...
Hong-Hsiang Guan, Yen-Hua Huang, En-Shyh Lin, Chun-Jung Chen, Cheng-Yang Huang   +4 more
doaj   +1 more source

Compensatory Mutations in Predicted Metal Transporters Modulate Auxin Conjugate Responsiveness in Arabidopsis [PDF]

, 2013
Levels of the phytohormone indole-3-acetic acid (IAA) can be altered by the formation and hydrolysis of IAA conjugates. The isolation and characterization of Arabidopsis thaliana mutants with reduced IAA-conjugate sensitivity and wild-type IAA responses ...
Arrivault, Assuncao, Ausubel, Bartel, Bell, Bitto, Blaudez, Bloß, Chang, Cheng, Clemens, Clough, Davies, Delhaize, Delhaize, Desbrosses-Fonrouge, Dunkley, Eide, Ellis, Fukunaka, Gaither, Gietz, Gollhofer, Gustin, Hall, Haughn, Huang, Jirakulaporn, Kambe, Kambe, Kawachi, Kawachi, Kim, Kobae, Koncz, Kumánovics, Lasswell, Lasswell, Last, LeClere, LeClere, Li, Li, MacDiarmid, Magidin, Marschner, Michaels, Montanini, Mäser, Neff, Normanly, Peiter, Persans, Rampey, Rampey, Rosso, Schwacke, Stasinopoulos, Strader, Taylor, Van Der Zaal, Winter, Woodward   +62 more
core   +1 more source

Methyl Jasmonate Seed Priming Mitigates the Defence‐Growth Trade‐Off and Tailors Plant Response to Specific Pests

Plant, Cell &Environment, EarlyView.
ABSTRACT Seed defence priming is emerging as a novel, cost‐efficient and environmentally safe tool for pest management. It has been proposed as a means to uncouple the defence‐growth trade‐off in plants by enhancing defence responses with minimal fitness costs, but the mechanisms underlying this role remain elusive.
Lucia Talavera‐Mateo, Adrian Sabater‐Gabriel, Alejandro Garcia, Marta Marina Perez‐Alonso, Rayko Halitschke, M. Estrella Santamaria   +5 more
wiley   +1 more source

Deciphering Physiological Functions of AHL Quorum Quenching Acylases

Frontiers in Microbiology, 2017
N-Acylhomoserine lactone (AHL)-acylase (also known as amidase or amidohydrolase) is a class of enzyme that belongs to the Ntn-hydrolase superfamily. As the name implies, AHL-acylases are capable of hydrolysing AHLs, the most studied signaling molecules ...
Putri D. Utari, Jan Vogel, Wim J. Quax
doaj   +1 more source

Structural Analyses on the Deamidation of N-Terminal Asn in the Human N-Degron Pathway

Biomolecules, 2020
The N-degron pathway is a proteolytic system in which a single N-terminal amino acid acts as a determinant of protein degradation. Especially, degradation signaling of N-terminal asparagine (Nt-Asn) in eukaryotes is initiated from its deamidation by N ...
Joon Sung Park, Jae-Young Lee, Yen Thi Kim Nguyen, Nae-Won Kang, Eun Kyung Oh, Dong Man Jang, Hyun-Jung Kim, Dae-Duk Kim, Byung Woo Han   +8 more
doaj   +1 more source

Analgesic Effects of Fatty Acid Amide Hydrolase Inhibition in a Rat Model of Neuropathic Pain [PDF]

, 2006
Cannabinoid-based medicines have therapeutic potential for the treatment of pain. Augmentation of levels of endocannabinoids with inhibitors of fatty acid amide hydrolase (FAAH) is analgesic in models of acute and inflammatory pain states.
Barrett, David, Chapman, Victoria, Jhaveri, Maulik, Kendall, David, Richardson, Denise   +4 more
core   +2 more sources

The Acylamide Amidohydrolase of Candida utilis: Purification and Properties [PDF]

Journal of General Microbiology, 1969
SUMMARY: The amidohydrolase formed in the later stages of growth on glucose peptone medium by Candida utilis was purified 60-fold from cell-free extracts. The purified enzyme hydrolysed mono- and di-carboxylic acid amides, benzamide, nicotinamide, pyrazinamide and certain β-hydroxyl substituted fatty acid amides, was inactive on l-asparagine and l ...
openaire   +2 more sources

The Hemoprotein Hhy1 Promotes Heme‐Dependent Catalase Activity of Ctt1

Molecular Microbiology, Volume 125, Issue 5, Page 389-411, May 2026.
A Schizosaccharomyces pombe strain deficient in heme (hem1Δ) and siderophore (Fc) biosynthesis, as well as high‐affinity iron (Fe) uptake (blue), was used to uncover the hemoprotein Hhy1 that promotes the heme‐dependent activity of the catalase Ctt1. In contrast, hhy1Δ cells exhibit reduced Ctt1 activity and increased sensitivity to oxidative stress ...
Tobias Vahsen, Samuel Plante, Berthy Mbuya, Simon Labbé   +3 more
wiley   +1 more source

A sulfoximine-based inhibitor of human asparagine synthetase kills l-asparaginase-resistant leukemia cells. [PDF]

, 2012
An adenylated sulfoximine transition-state analogue 1, which inhibits human asparagine synthetase (hASNS) with nanomolar potency, has been reported to suppress the proliferation of an l-asparagine amidohydrolase (ASNase)-resistant MOLT-4 leukemia cell ...
Ahn, Yong-Mo, Hegazy, Lamees, Hiratake, Jun, Ikeuchi, Hideyuki, Otokawa, Takuya, Richards, Nigel G J, Watanabe, Bunta   +6 more
core   +1 more source