Comparative Analysis of Mesophilic YqfB-Type Amidohydrolases [PDF]
Biomolecules, 2022 The widespread superfamily of the human activating signal cointegrator homology (ASCH) domain was identified almost 20 years ago; however, the amount of experimental data regarding the biological function of the domain is scarce.
Roberta Statkevičiūtė +4 more
doaj +6 more sources
Bacterial amidohydrolases and modified 5-fluorocytidine compounds: Novel enzyme-prodrug pairs. [PDF]
PLoS ONE, 2023 Gene-directed enzyme prodrug therapy is an emerging strategy for cancer treatment based on the delivery of a gene that encodes an enzyme that is able to convert a prodrug into a potent cytotoxin exclusively in target cancer cells.
Viktorija Preitakaitė +6 more
doaj +3 more sources
Characterization of Four Bifunctional Plant IAM/PAM-Amidohydrolases Capable of Contributing to Auxin Biosynthesis [PDF]
Plants, 2014 Amidases [EC 3.5.1.4] capable of converting indole-3-acetamide (IAM) into the major plant growth hormone indole-3-acetic acid (IAA) are assumed to be involved in auxin de novo biosynthesis.
Beatriz Sánchez-Parra +6 more
doaj +6 more sources
Auxin Amidohydrolases – From Structure to Function: Revisited [PDF]
Croatica Chemica Acta, 2018 The control of plant growth and development is a well-coordinated process between exogenous and endogenous signals. Auxins are plant hormones belonging to the endogenous signals, which control a vast array of different processes.
Ana Smolko +2 more
core +5 more sources
Inhibition of a Putative Dihydropyrimidinase from Pseudomonas aeruginosa PAO1 by Flavonoids and Substrates of Cyclic Amidohydrolases. [PDF]
PLoS ONE, 2015 Dihydropyrimidinase is a member of the cyclic amidohydrolase family, which also includes allantoinase, dihydroorotase, hydantoinase, and imidase. These metalloenzymes possess very similar active sites and may use a similar mechanism for catalysis ...
Cheng-Yang Huang
doaj +2 more sources
Penicillin Amidohydrolases in Fungal Autolysis [PDF]
Microbiology and Immunology, 1989 AbstractThe production of penicillin G and penicillin V amidohydrolases or acylases (E.C.3.5.1.11) was studied during the autolysis of filamentous fungi in a mineral medium, and in the same medium with phenoxyacetic acid as inducer. In all the studied fungi, enzymes showing penicillin G and penicillin V amidohydrolase activities were found.
C. Alfonso, L. Cribeiro, F. Reyes
semanticscholar +4 more sources
Synthetic and Systems Biotechnology, 2017 2,2′-Bipyridine (2,2′-BiPy) is an attractive core structure present in a number of biologically active natural products, including the structurally related antibiotics caerulomycins (CAEs) and collismycins (COLs).
Ming Chen +4 more
doaj +2 more sources
Crystal structure of N-carbamyl-D-amino acid amidohydrolase with a novel catalytic framework common to amidohydrolases. [PDF]
Structure, 2000 N-carbamyl-D-amino acid amidohydrolase (DCase) catalyzes the hydrolysis of N-carbamyl-D-amino acids to the corresponding D-amino acids, which are useful intermediates in the preparation of beta-lactam antibiotics. To understand the catalytic mechanism of N-carbamyl-D-amino acid hydrolysis, the substrate specificity and thermostability of the enzyme, we
T. Nakai +11 more
semanticscholar +4 more sources
Discovery and In Vitro Reconstitution of Closoxazole Biosynthesis from Pyxidicoccus fallax. [PDF]
ChembiochemThe myxobacterium Pyxidicoccus fallax is found to be a producer of benzoxazole‐containing natural products named closoxazoles. In vitro studies with the biosynthetic enzymes reveal new insights into the reaction mechanism for closoxazole formation.
Lernoud L +4 more
europepmc +2 more sources
Structural and biophysical aspects of l-asparaginases: a growing family with amazing diversity
IUCrJ, 2021 l-Asparaginases have remained an intriguing research topic since their discovery ∼120 years ago, especially after their introduction in the 1960s as very efficient antileukemic drugs.
Joanna I. Loch, Mariusz Jaskolski
doaj +1 more source