Results 111 to 120 of about 205,880 (261)

Multidrug-resistant Escherichia coli, Klebsiella pneumoniae and Staphylococcus spp. in houseflies and blowflies from farms and their environmental settings [PDF]

, 2019
Background: Antimicrobial resistance is rising globally at an alarming rate. While multiple active surveillance programs have been established to monitor the antimicrobial resistance, studies on the environmental link to antimicrobial spread are lacking.
Adekanmbi, Folesade, Butaye, Patrick, Cattley, Russell, Hathcock, Terri, Kalalah, Anwar, Kang, Yuan, Macklin, Kenneth, Poudel, Anil, Price, Stuart, Walz, Paul, Wang, Chengming   +10 more
core   +1 more source

Evaluation of Amikacin Pharmacokinetics and Pharmacodynamics for Optimal Initial Dosing Regimen

Drugs in R&D, 2017
Amikacin has been one of the important antimicrobial agents against Gram-negative pathogens. However, there is discrepancy regarding the amikacin initial dosage, with some reports recently recommending ≥25 mg/kg and others the conventional dosage (15–20 ...
Hideo Kato, M. Hagihara, J. Hirai, Daisuke Sakanashi, H. Suematsu, Naoya Nishiyama, Yusuke Koizumi, Y. Yamagishi, K. Matsuura, H. Mikamo   +9 more
semanticscholar   +1 more source

Induction of Apoptosis in MCF‐7 Breast Cancer Cells by Selenium Nanoparticles Synthesized With Laccase Enzyme Isolated From Pleurotus Floridanus

eFood, Volume 7, Issue 3, June 2026.
This study showed the first successful synthesis of selenium nanoparticles (SeNPs) using laccase purified from Pleurotus floridanus, offering an eco‐friendly and biocompatible replacement to conventional chemical methods. The biosynthesized SeNPs exhibited significant antiproliferative effects on MCF‐7 breast cancer cells, with cell cycle analysis ...
Shenbhagaraman Ramalingam, Arthi Karunanithi, Ammar B. Altemimi, Jenefar Sudarson, Sakthivel Muthu, Kodiganti Naresh Kumar, Rawaa H. Tlay, Tarek Gamal Abedelmaksoud   +7 more
wiley   +1 more source

Risk factors of infective endocarditis-associated acute kidney injury: benefits of low-dose amikacin and surgery

Annals of Medicine
Objective Acute kidney injury (AKI) is a frequent presentation in patients with infective endocarditis (IE), and is associated with poor outcomes. The primary aim of the study was to determine the risk factors for AKI in patients with IE.Methods A ...
SanXi Ai, XinPei Liu, Nan Zhao, Qi Miao, Yan Qin, XueMei Li   +5 more
doaj   +1 more source

Antagonism between Front-Line Antibiotics Clarithromycin and Amikacin in the Treatment of Mycobacterium abscessus Infections Is Mediated by the whiB7 Gene

Antimicrobial Agents and Chemotherapy, 2017
Combinations of antibiotics, each individually effective against Mycobacterium abscessus, are routinely coadministered based on the concept that this minimizes the spread of antibiotic resistance. However, our in vitro data contradict this assumption and
Mark Pryjma, J. Burian, Kevin S. Kuchinski, C. Thompson   +3 more
semanticscholar   +1 more source

Challenges in Diagnosing and Treating Percutaneous Nephrostomy‐Related Urinary Tract Infection in Cancer Patients: A Retrospective Cohort Study

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Objective We aimed to evaluate medical decisions regarding urinary tract infection (UTI), describe associated microorganisms, and assess potential risk factors for percutaneous nephrostomy‐related UTI (UTI‐PN). Methods Oncological patients who underwent percutaneous nephrostomy (PN) were included. We assessed percutaneous nephrostomy procedure‐
Jeferson Rodrigo Zanon, Marcelo Jenné Mimica, José Humberto Tavares Guerreiro Fregnani, Ricardo dos Reis   +3 more
wiley   +1 more source

Polymyxin Combinations Combat Escherichia coli Harboring mcr-1 and bla_NDM-5: Preparation for a Postantibiotic Era

mBio, 2017
The rapid increase of carbapenem resistance in Gram-negative bacteria has resurrected the importance of the polymyxin antibiotics. The recent discovery of plasmid-mediated polymyxin resistance (mcr-1) in carbapenem-resistant Enterobacteriaceae serves as ...
Zackery P. Bulman, Liang Chen, Thomas J. Walsh, Michael J. Satlin, Yuli Qian, Jürgen B. Bulitta, Charles A. Peloquin, Patricia N. Holden, Roger L. Nation, Jian Li, Barry N. Kreiswirth, Brian T. Tsuji   +11 more
doaj   +1 more source

Actionable Pharmacogenomics and Essential Medicines: An Analysis of WHO and African Lists for Safer and Efficacious Drug Use

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1371-1381, May 2026.
The World Health Organization Model Essential Medicines List and African national essential medicines lists (EMLs) detail drugs intended to be consistently available within national health systems, thereby supporting clinicians and pharmacists in making evidence‐based treatment decisions.
Tinashe A. Mazhindu, Mohamed Nagy, David Twesigomwe, Gaye Agesa, Janine Scholefield, Collen Masimirembwa   +5 more
wiley   +1 more source

The Burden of Adverse Drug Reactions in Africa in the Context of Pharmacogenetics‐Based Clinical Guidelines

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1382-1390, May 2026.
Genetic variation has a significant impact on patients' response to medicines. Variations in important pharmacogenes have been evaluated in several studies and consequently led to international guidelines from clinical pharmacogenomics consortia. However, there are limited examples of these being implemented across the African continent despite the ...
Janine Scholefield, Tinashe A. Mazhindu, Mohamed Nagy, David Twesigomwe, Gaye Agesa, Collen Masimirembwa   +5 more
wiley   +1 more source

Phenotypic and Genotypic Study of Antibiotic Resistance blaPER‐1, blaVEB, and blaSHV‐1 Genes in Clinical Isolates of Pseudomonas aeruginosa

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Pseudomonas aeruginosa is a non‐fermentative, opportunistic Gram‐negative bacterium that causes 10%–15% of nosocomial and burn wound infections worldwide. This bacterium is resistant to various antibiotics through multiple mechanisms, including acquisition of resistance genes.
Milad Gholampour Matin, Reza Shapouri, Mohammadreza Nahaei, Mojtaba Mohammadi Roknabadi, Rasoul Shokri   +4 more
wiley   +1 more source