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Lithium‐induced kidney injury and fibrosis: A versatile model to explore cellular pathways of injury and repair [PDF]

Physiological Reports
Lithium‐induced kidney injury is commonly associated with the development of nephrogenic diabetes insipidus. Longer term lithium exposure is associated with the development of chronic interstitial fibrosis. The mechanisms of lithium‐induced kidney injury
Paulomi Mehta, Tania Slatter, Robert Walker   +2 more
doaj   +2 more sources

Amiloride hydrochloride methanol disolvate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
IN THE CRYSTAL OF THE TITLE COMPOUND [SYSTEMATIC NAME: 2-(3,5-diamino-6-chloro-pyrazin-2-ylcarbon-yl)guanidinium chloride methanol disolvate], C(6)H(9)ClN(7)O(+)·Cl(-)·2CH(3)OH , the components are connected by N-H⋯N, N-H⋯Cl, N-H⋯O, O-H⋯Cl and O-H⋯O hydrogen bonds into a three-dimensional network.
Cuong, Ton Quoc, Bolte, Michael
openaire   +7 more sources

Low pH induces amiloride-sensitive expression of leukemia inhibitory factor in endometrial cells [PDF]

The Journal of Reproduction and Development
An association has been reported between a lower pH in the uterus and an increased rate of implantation. How low pH regulates endometrial function is unclear.
Miku OTSUGU, Ayumi MINE, Kurumi FUJIWARA, Ayako ICHIMURA, Keiji YAMAMOTO, Ryo TACHIHARA, Hideaki TOMURA   +6 more
doaj   +2 more sources

Paradoxical Potentiation of Acid-Sensing Ion Channel 3 (ASIC3) by Amiloride via Multiple Mechanisms and Sites Within the Channel

Frontiers in Physiology, 2021
Acid-Sensing Ion Channels (ASICs) are proton-gated sodium-selective cation channels that have emerged as metabolic and pain sensors in peripheral sensory neurons and contribute to neurotransmission in the CNS.
Daniel S. Matasic, Daniel S. Matasic, Nicholas Holland, Nicholas Holland, Mamta Gautam, Mamta Gautam, David D. Gibbons, David D. Gibbons, Nobuyoshi Kusama, Nobuyoshi Kusama, Anne M. S. Harding, Anne M. S. Harding, Viral S. Shah, Peter M. Snyder, Peter M. Snyder, Peter M. Snyder, Christopher J. Benson, Christopher J. Benson, Christopher J. Benson   +18 more
doaj   +1 more source

Epithelial Sodium Channel Inhibition by Amiloride Addressed with THz Spectroscopy and Molecular Modeling

Molecules, 2022
THz spectroscopy is important for the study of ion channels because it directly addresses the low frequency collective motions relevant for their function. Here we used THz spectroscopy to investigate the inhibition of the epithelial sodium channel (ENaC)
Maria Mernea, Roxana Ștefania Ulăreanu, Dana Cucu, Jasim Hafedh Al-Saedi, Cristian-Emilian Pop, Sergiu Fendrihan, Giorgiana Diana Carmen Anghelescu, Dan Florin Mihăilescu   +7 more
doaj   +1 more source

Reduction of lithium induced interstitial fibrosis on co-administration with amiloride

Scientific Reports, 2022
Long-term administration of lithium is associated with chronic interstitial fibrosis that is partially reduced with exposure to amiloride. We examined potential pathways of how amiloride may reduce interstitial fibrosis.
Paulomi M. Mehta, Gregory Gimenez, Robert J. Walker, Tania L. Slatter   +3 more
doaj   +1 more source

Small molecule amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells. [PDF]

PLoS ONE, 2011
Alternative splicing involves differential exon selection of a gene transcript to generate mRNA and protein isoforms with structural and functional diversity.
Jan-Gowth Chang, Den-Mei Yang, Wen-Hsin Chang, Lu-Ping Chow, Wen-Ling Chan, Hui-Hua Lin, Hsien-Da Huang, Ya-Sian Chang, Cheng-Hao Hung, Wen-Kuang Yang   +9 more
doaj   +1 more source

6-Furopyridine Hexamethylene Amiloride Is a Non-Selective P2X7 Receptor Antagonist

Biomolecules, 2022
P2X7 is an extracellular adenosine 5′-triphopshate (ATP)-gated cation channel present on leukocytes, where its activation induces pro-inflammatory cytokine release and ectodomain shedding of cell surface molecules.
Peter Cuthbertson, Amal Elhage, Dena Al-Rifai, Reece A. Sophocleous, Ross J. Turner, Ashraf Aboelela, Hiwa Majed, Richard S. Bujaroski, Iman Jalilian, Michael J. Kelso, Debbie Watson, Benjamin J. Buckley, Ronald Sluyter   +12 more
doaj   +1 more source

Ex Vivo Pulmonary Oedema after In Vivo Blast-Induced Rat Lung Injury: Time Dependency, Blast Intensity and Beta-2 Adrenergic Receptor Role

Biomedicines, 2022
Objective: Current treatments for blast-induced lung injury are limited to supportive procedures including mechanical ventilation. The study aimed to investigate the role of post-trauma-induced oedema generation in the function of time and trauma ...
Hanno Huwer, Yalda Hadizamani, Ueli Moehrlen, Uz Stammberger, Florian Gebhard, Lia Bally, Albrecht Wendel, Ulrich C. Liener, Rudolf Lucas, Jürg Hamacher   +9 more
doaj   +1 more source

Antifungal activity of 6-substituted amiloride and hexamethylene amiloride (HMA) analogs

Frontiers in Cellular and Infection Microbiology, 2023
Fungal infections have become an increasing threat as a result of growing numbers of susceptible hosts and diminishing effectiveness of antifungal drugs due to multi-drug resistance.
Kiem Vu, Benjamin J. Buckley, Benjamin J. Buckley, Richard S. Bujaroski, Richard S. Bujaroski, Richard S. Bujaroski, Eduardo Blumwald, Michael J. Kelso, Michael J. Kelso, Angie Gelli   +9 more
doaj   +1 more source