Results 11 to 20 of about 31,652 (216)
Gitelman Syndrome Presenting With Syncope and Treatment-Refractory Hypokalemia in A Young Woman: A Case Report. [PDF]
Clin Case RepABSTRACT Gitelman syndrome (GS) is a rare autosomal recessive tubulopathy characterized by hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria. A 27‐year‐old woman presented with a witnessed syncopal episode, progressive weakness, and nausea.
Melkie IS +5 more
europepmc +2 more sources
Physiological Reports, 2022 The maintenance of endothelial health is required for normal vascular function and blood pressure regulation. The epithelial Na+ channel (ENaC) in endothelial cells has emerged as a new molecular player in the regulation of endothelial nitric oxide ...
Stephanie M. Mutchler, Thomas R. Kleyman
doaj +1 more source
Journal of the Renin-Angiotensin-Aldosterone System, 2020 Amiloride is a potassium retaining diuretic and natriuretic which acts by reversibly blocking luminal epithelial sodium channels (ENaCs) in the late distal tubule and collecting duct. Amiloride is indicated in oedematous states, and for potassium conservation adjunctive to thiazide or loop diuretics for hypertension, congestive heart failure and ...
Qianhui Sun, Peter Sever
openaire +3 more sources
Stability of extemporaneously compounded amiloride nasal spray.
PLoS ONE, 2020 Anxiety disorders (AD) are the most common mental conditions affecting an estimated 40 million adults in the United States. Amiloride, a diuretic agent, has shown efficacy in reducing anxious responses in preclinical models by inhibiting the acid-sensing
Venkata Yellepeddi +6 more
doaj +1 more source
Fidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds. [PDF]
PLoS Pathogens, 2010 In a screen for RNA mutagen resistance, we isolated a high fidelity RNA dependent RNA polymerase (RdRp) variant of Coxsackie virus B3 (CVB3). Curiously, this variant A372V is also resistant to amiloride.
Laura I Levi +6 more
doaj +1 more source
The Antifungal Activity of HMA, an Amiloride Analog and Inhibitor of Na+/H+ Exchangers
Frontiers in Microbiology, 2021 One path toward identifying effective and easily accessible antifungals is to repurpose commonly used drugs. Amiloride, a widely used diuretic, inhibits different isoforms of Na+/H+ exchangers, Na+ channels, and Na+/Ca2+ exchangers.
Kiem Vu, Eduardo Blumwald, Angie Gelli
doaj +1 more source
Skeletal Muscle, 2021 Background Cancer cachexia (CAC) reduces patient survival and quality of life. Developments of efficient therapeutic strategies are required for the CAC treatments.
Lin Zhou +12 more
doaj +1 more source
Amiloride reduces portal hypertension in rat liver cirrhosis [PDF]
, 2010 Objective This study aimed to investigate the effect of amiloride on portal hypertension. Amiloride is known to inhibit Na(+)/H(+) exchangers on activated hepatic stellate cells.
Beitinger, Frigga +6 more
core +1 more source
A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells. [PDF]
PLoS ONE, 2013 Amiloride is a potassium-sparing diuretic that has been used as an anti-kaliuretic for the chronic management of hypertension and heart failure. Several studies have identified a potential anti-cancer role for amiloride, however the mechanisms underlying
Leonardo J Leon +3 more
doaj +1 more source
Na+-H+ exchange activity in brush-border membrane vesicles isolated from chick small intestine [PDF]
, 1995 This study was undertaken to investigate the presence of a Na+{single bond}H+ antiporter in brush-border membrane vesicles (BBMV) isolated from chick small intestine.
Cano Rodríguez, María Mercedes +2 more
core +1 more source