Results 61 to 70 of about 31,652 (216)

Calcium channels controlling acetylcholine release from preganglionic nerve terminals in rat autonomic ganglia [PDF]

, 1999
Little is known about the nature of the calcium channels controlling neurotransmitter release from preganglionic parasympathetic nerve fibres. In the present study, the effects of selective calcium channel antagonists and amiloride were investigated on ...
A.B Smith, Boot, Bowersox, Brock, Brock, D.J Adams, De Luca, Dunlap, Gonzalez-Burgos, Hong, Ireland, L Motin, Lavidis, Lin, Lundy, McDonough, Meir, N.A Lavidis, Randall, Randall, Rogers, Seabrook, Smith, Smith, Smith, Smith, Snider, Tabatabai, Tang, Todorovic, Warren, Waterman, Wright, Wu   +33 more
core   +1 more source

Astrocytic Mitochondria Transplantation Rescues Neuron Loss and Dendritic Injuries in Acute Cerebral Ischemic Stroke Mouse Model by Flexibly Regulating Mitochondria Dynamics

Annals of Neurology, EarlyView.
Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian, Jianing Shen, Linwei Tian, Jinghui Li, Lu Yang, Bo Yuan, Shulin Li, Yuyu Niu, Lu Zhao, Jingkuan Wei   +9 more
wiley   +1 more source

Identification of functionally distinct Na-HCO3 co-transporters in colon. [PDF]

PLoS ONE, 2013
Na-HCO3 cotransport (NBC) regulates intracellular pH (pHi) and HCO3 secretion in rat colon. NBC has been characterized as a 5,5'-diisothiocyanato-2-2'-stilbene (DIDS)-sensitive transporter in several tissues, while the colonic NBC is sensitive to both ...
Christian Barmeyer, Jeff Huaqing Ye, Carol Soroka, Peter Geibel, Lukas M Hingsammer, Laurence Weitgasser, Danny Atway, John P Geibel, Henry J Binder, Vazhaikkurichi M Rajendran   +9 more
doaj   +1 more source

Mucin Glycoprotein Nanoparticles Enable a Selective Antisense Therapy for Oncogenic MicroRNAs

Advanced NanoBiomed Research, EarlyView.
Mucin glycoproteins are turned into nanoparticles by employing synthetic DNA strands, which have a dual function: they stabilize the nanoparticles and act as binding sites for intracellular miRNA‐21. Thus, upon internalization into tumor cells, these mucin nanoparticles can deplete miRNA‐21 from the cytosol, which induces apoptosis in vitro and in vivo.
Ceren Kimna, Thomas Mayer, Di Zhang, Matthias Marczynski, Carolin A. Rickert, Fabio Henkel, Lennart J. K. Weiss, Friedrich C. Simmel, Yuxia Luan, Oliver Lieleg   +9 more
wiley   +1 more source

Role of endogenous ENaC and TRP channels in the myogenic response of rat posterior cerebral arteries. [PDF]

PLoS ONE, 2013
Mechanogated ion channels are predicted to mediate pressure-induced myogenic vasoconstriction in small resistance arteries. Recent findings have indicated that transient receptor potential (TRP) channels and epithelial sodium channels (ENaC) are involved
Eok-Cheon Kim, Soo-Kyoung Choi, Mihwa Lim, Soo-In Yeon, Young-Ho Lee   +4 more
doaj   +1 more source

Depletion of Na⁺/H⁺ Exchanger Isoform 1 Increases the Host Cell Resistance to Trypanosoma cruzi Invasion

Pathogens, 2022
Na+/H+ exchanger isoform 1 (NHE1), a member of a large family of integral membrane proteins, plays a role in regulating the cortical actin cytoskeleton.
João Paulo Ferreira Rodrigues, Leonardo Loch, Thiago Souza Onofre, Nobuko Yoshida   +3 more
doaj   +1 more source

Cholesterol-directed nanoparticle assemblies based on single amino acid peptide mutations activate cellular uptake and decrease tumor volume. [PDF]

, 2017
Peptide drugs have been difficult to translate into effective therapies due to their low in vivo stability. Here, we report a strategy to develop peptide-based therapeutic nanoparticles by screening a peptide library differing by single-site amino acid ...
Landry, Markita P, Li, Shang, Tu, Yaoquan, Wu, Junchen, Zou, Rongfeng   +4 more
core   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

The Role of Epithelial Sodium Channel ENaC and the Apical Cl-/HCO3- Exchanger Pendrin in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation. [PDF]

PLoS ONE, 2016
The absence of NCC does not cause significant salt wasting in NCC deficient mice under basal conditions. We hypothesized that ENaC and pendrin play important roles in compensatory salt absorption in the setting of NCC inactivation, and their inhibition ...
Mina Patel-Chamberlin, Mujan Varasteh Kia, Jie Xu, Sharon Barone, Kamyar Zahedi, Manoocher Soleimani   +5 more
doaj   +1 more source

Pharmacological inhibition of sodium-calcium exchange activates NADPH oxidase and induces infection-independent NETotic cell death

Redox Biology, 2021
In addition to its function of innate immunity against invading pathogens, neutrophil extracellular traps (NETs) promote thrombosis, autoimmune disease, and cancer metastasis; therefore, unnecessary exposure to the triggers of infection-independent NET ...
Minoru Inoue, Masahiro Enomoto, Michio Yoshimura, Takashi Mizowaki   +3 more
doaj   +1 more source