Results 171 to 180 of about 67,576 (269)

Using MD Simulations to Understand the Impact of Directed Evolution on Oxygen Affinity in Amine Oxidases

ChemistryOpen, Volume 15, Issue 4, April 2026.
A combination of experimental and computational experiments has been used to understand oxygen needs for evolved amine oxidase enzymes. Two variants of amine oxidase from Aspergillus niger were shown to have different oxygen requirements in the oxidation of a model substrate, with molecular dynamics simulations used to model the differences between the
Christopher R. Field, Rowan Lindeque, Jonathan P. Dolan, Julie Østerby Madsen, Sam Hay, Nicholas J. Turner, John M. Woodley, Sebastian C. Cosgrove   +7 more
wiley   +1 more source

Sequence‐Modulated Active Tripeptide Condensates for Tandem Catalysis

Angewandte Chemie, Volume 138, Issue 13, 23 March 2026.
Sequence‐modulated tripeptide coacervates mimic biomolecular condensates with controllable, enzyme‐regulated phase separation. They co‐sequester hydrophobic active species and hydrophilic enzymes, enabling tandem catalysis in aqueous media. Incorporated into artificial cells, they function as adaptive sub‐organelles, orchestrating compartmentalized ...
Hao Han, Siyu Song, Jianqiang Wang, Tsvetomir Ivanov, Dongdong Zhou, Hao Su, Katharina Landfester, Shoupeng Cao   +7 more
wiley   +2 more sources

Novel glycine amides, semicarbazides and fluoroallylamines as inhibitors of the amine oxidase vascular adhesion protein-1 (VAP-1). [PDF]

RSC Med Chem
Pöstges T, Kampschulze J, Hanekamp W, Bermúdez M, Lehr M.   +4 more
europepmc   +1 more source

Mitochondrial Ca2+ overload is a pivotal risk factor for lethal ventricular arrhythmias due to the oxidation of mitochondrial respirasome and energetic failure

British Journal of Pharmacology, Volume 183, Issue 7, Page 1404-1426, April 2026.
The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez, Luis Alberto Luévano‐Martínez, Abraham Méndez‐Fernández, Judith Bernal‐Ramírez, Carolina A. Morales‐Ochoa, Christian Silva‐Platas, Alfredo Cabrera‐Orefice, Ana C. Murrieta, José Luis Velasco‐Bolom, Gricelda Mendiola‐Garza, Flavio Contreras‐Torres, Guillermo Torre‐Amione, Ernesto A. Aiello, Gerardo García‐Rivas   +13 more
wiley   +1 more source

Biosynthesis of Kaitocephalin: A Neuroprotective Natural Product Featuring a Peptide‐Like yet Nonpeptidic Scaffold

Angewandte Chemie, Volume 138, Issue 13, 23 March 2026.
Kaitocephalin (KCP) is a neuroprotective fungal metabolite with a unique scaffold of amino acids linked via C–C bonds. Genome‐transcriptome analyses identified its biosynthetic gene cluster (kpb cluster) in Eupenicillium shearii. LC‐MS/MS profiling identified four new KCP‐related compounds.
Yukari Maeno, Taro Shiraishi, Naoya Saito, Jun‐ichi Maruyama, Kazuo Shin‐ya, Tomohisa Kuzuyama   +5 more
wiley   +2 more sources

AMINE OXIDASES

Journal of Biological Chemistry, 1955
E. Albert Zeller, James Barsky, Elaine R. Berman   +2 more
openaire   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, Volume 183, Issue 7, Page 1364-1389, April 2026.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Real-time capture of domain movements during copper amine oxidase catalysis by mix-and-inject serial crystallography. [PDF]

Nat Commun
Murakawa T, Suzuki M, Fukui K, Masuda T, Mizohata E, Miyahara I, Kurauchi I, Murakami T, Matsunaga H, Montawa Y, Nakajima N, Oozeki T, Sakai K, Son T, Higuchi T, Sunami T, Kimura T, Tono K, Tanaka T, Sugahara M, Arima T, Fangjia L, Kang J, Tanaka R, Iwata S, Nango E, Tosha T, Yano T, Tanizawa K, Okajima T.   +29 more
europepmc   +1 more source

DEER and RIDME Measurements of the Nitroxide-Spin Labelled Copper-Bound Amine Oxidase Homodimer from Arthrobacter Globiformis. [PDF]

Appl Magn Reson, 2021
Russell H, Stewart R, Prior C, Oganesyan VS, Gaule TG, Lovett JE.   +5 more
europepmc   +1 more source

Comparative study of the conformational lock, dissociative thermal inactivation and stability of Euphorbia latex and lentil seedling amine oxidases [PDF]

The thermal stability of copper/quinone containing amine oxidases from Euphorbia characias latex (ELAO) and lentil seedlings (LSAO) was measured in 100 mM potassium phosphate buffer (pH 7.0) following changes in absorbance at 292 nm. ELAO was shown to be
احمد, فیضان, امانی, مجتبی, صبوری, علی اکبر, فلوریس, جیووانی, لونگو, س, مورا, آنا, موسوی موحدی, علی اکبر, موسوی نژاد, سیده زهرا   +7 more
core