Zinc-α2-glycoprotein as an inhibitor of amine oxidase copper-containing 3. [PDF]
Open Biol, 2020 AbstractZinc-alpha2-glycoprotein (ZAG) is a major plasma protein whose levels increase in chronic energy-demanding diseases and thus serves as an important clinical biomarker in the diagnosis and prognosis of the development of cachexia. Current knowledge suggests that ZAG mediates progressive weight loss through β-adrenergic signaling in adipocytes ...
Romauch M.
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The tree of life of copper-containing amine oxidases. [PDF]
Front Plant SciCopper-containing amine oxidases (CuAOs) catalyze the terminal oxidation of polyamines (PAs), producing ammonium, an aminoaldehyde, and hydrogen peroxide (H2O2). Plant CuAOs are induced by stress-related hormones such as methyl-jasmonate (MeJA), abscisic acid (ABA), and salicylic acid (SA).
Zhang Z +5 more
europepmc +6 more sources
Amine oxidase copper-containing 3 (AOC3) inhibition: a potential novel target for the management of diabetic retinopathy. [PDF]
Int J Retina Vitreous, 2021 Background Diabetic retinopathy (DR), a microvascular complication of diabetes, is the leading cause of visual impairment in people aged 20–65 years and can go undetected until vision is irreversibly lost.
Boyer DS +5 more
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A randomised Phase IIa trial of amine oxidase copper-containing 3 (AOC3) inhibitor BI 1467335 in adults with non-alcoholic steatohepatitis. [PDF]
Nat Commun, 2023 Non-alcoholic steatohepatitis (NASH) is a progressive, inflammatory liver disease with no approved pharmacological treatment. This Phase IIa, double-blind, placebo-controlled, multicentre trial (ClinicalTrials.gov: NCT03166735) investigated ...
Newsome PN +10 more
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Human Copper-Containing Amine Oxidases in Drug Design and Development [PDF]
Molecules, 2020 Two members of the copper-containing amine oxidase family are physiologically important proteins: (1) Diamine oxidase (hDAO; AOC1) with a preference for diamines is involved in degradation of histamine and (2) Vascular adhesion protein-1 (hVAP-1; AOC3) with a preference for monoamines is a multifunctional cell-surface receptor and an enzyme.
Serhii Vakal +3 more
doaj +8 more sources
Past, Present and Future Anti-Obesity Effects of Flavin-Containing and/or Copper-Containing Amine Oxidase Inhibitors [PDF]
Medicines, 2019 Background: Two classes of amine oxidases are found in mammals: those with a flavin adenine dinucleotide as a cofactor, such as monoamine oxidases (MAO) and lysine-specific demethylases (LSD), and those with copper as a cofactor, including copper ...
Christian Carpéné +3 more
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Exploring Molecular Oxygen Pathways in Hansenula polymorpha Copper-containing Amine Oxidase [PDF]
Journal of Biological Chemistry, 2007 The accessibility of large substrates to buried enzymatic active sites is dependent upon the utilization of proteinaceous channels. The necessity of these channels in the case of small substrates is questionable because diffusion through the protein matrix is often assumed.
Arwen R. Pearson +6 more
semanticscholar +6 more sources
Crystal structure of a eukaryotic (pea seedling) copper-containing amine oxidase at 2.2 å resolution [PDF]
Structure, 1996 Copper-containing amine oxidases catalyze the oxidative deamination of primary amines to aldehydes, in a reaction that requires free radicals. These enzymes are important in many biological processes, including cell differentiation and growth, would healing, detoxification and signalling.
Hans C. Freeman +7 more
semanticscholar +5 more sources
Amine oxidase, copper containing 3 exerts anti‑mesenchymal transformation and enhances CD4+ T‑cell recruitment to prolong survival in lung cancer. [PDF]
Oncol Rep, 2021 Lung cancer remains notorious for its poor prognosis. Despite the advent of tyrosine kinase inhibitors and immune checkpoint inhibitors, the probability of curing the disease in lung cancer patients remains low.
Chang CY +10 more
europepmc +4 more sources
Amine Oxidase, Copper Containing 3 (Aoc3) Knockout Mice Are More Prone to DSS-induced Colitis and Colonic Tumorigenesis. [PDF]
In VivoBackground/Aim: Inflammatory bowel diseases and colorectal cancer are a major cause of morbidity and mortality. Amine oxidase, copper-containing 3 (AOC3) is a critical enzyme in the physiological trafficking of leukocytes and the regulation of ...
Özcan Ö, Akyol Ö, Akyol A.
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