Results 11 to 20 of about 21,994 (249)

Real-time capture of domain movements during copper amine oxidase catalysis by mix-and-inject serial crystallography [PDF]

Nature Communications
Protein dynamics play a crucial role in various physiological functions, including enzyme catalysis. To explore conformational changes during enzyme catalysis, we conduct mix-and-inject serial crystallography, an advanced technique to capture time ...
Takeshi Murakawa, Mamoru Suzuki, Kenji Fukui, Tetsuya Masuda, Eiichi Mizohata, Ikuko Miyahara, Ikuya Kurauchi, Taiki Murakami, Himawari Matsunaga, Yoshiki Montawa, Norie Nakajima, Toshinori Oozeki, Katsuki Sakai, Teikoku Son, Takehiro Higuchi, Tomoko Sunami, Tetsunari Kimura, Kensuke Tono, Tomoyuki Tanaka, Michihiro Sugahara, Toshi Arima, Luo Fangjia, Jungmin Kang, Rie Tanaka, So Iwata, Eriko Nango, Takehiko Tosha, Takato Yano, Katsuyuki Tanizawa, Toshihide Okajima   +29 more
doaj   +2 more sources

Exploring Molecular Oxygen Pathways in Hansenula polymorpha Copper-containing Amine Oxidase [PDF]

Journal of Biological Chemistry, 2007
The accessibility of large substrates to buried enzymatic active sites is dependent upon the utilization of proteinaceous channels. The necessity of these channels in the case of small substrates is questionable because diffusion through the protein matrix is often assumed.
Bryan Johnson, Jordi Cohen, Richard W.D. Welford, Arwen R. Pearson, Klaus Schulten, Judith P. Klinman, Carrie M. Wilmot   +6 more
openalex   +4 more sources

Zinc-α2-Glycoprotein Is An Inhibitor Of Amine Oxidase Copper-Containing 3 [PDF]

Open Biology, 2019
AbstractZinc-alpha2-glycoprotein (ZAG) is a major plasma protein whose levels increase in chronic energy-demanding diseases and thus serves as an important clinical biomarker in the diagnosis and prognosis of the development of cachexia. Current knowledge suggests that ZAG mediates progressive weight loss through β-adrenergic signaling in adipocytes ...
Matthias Romauch
openalex   +5 more sources

Interaction of Pig Kidney and Lentil Seedling Copper-Containing Amine Oxidases with Guanidinium Compounds [PDF]

Journal of Enzyme Inhibition, 1999
The effect of guanidinium compounds on the catalytic mechanism of pig kidney and lentil seedling amine oxidases has been investigated by polarographic techniques and spectroscopy. Guanidine does not inhibit the lentil enzyme and is a weak inhibitor for pig kidney amine oxidase (K(i) =1 mM), whereas aminoguanidine is an irreversible inhibitor of both ...
Alessandra Padiglia, Rosaria Medda, Anita Lorrai, Barbara Murgia, Jens Z. Pedersen, Alessandro Finazzi Agrò, Giovanni Floris   +6 more
openalex   +6 more sources

Pan-cancer analysis reveals AOC3 as a potential therapeutic biomarker for colorectal cancer [PDF]

Discover Oncology
Amine oxidase copper containing 3 (AOC3) had been reported to play an important regulatory role in the biological functional pathways, immune microenvironment and cellular function.
Guanlong Wang, Lidan Zhu, Ling Lu, Guangyang Wu, Bangjie Wang, Changjun Yu   +5 more
doaj   +2 more sources

Amine oxidase, copper containing 3 exerts anti‑mesenchymal transformation and enhances CD4⁺ T‑cell recruitment to prolong survival in lung cancer. [PDF]

Oncol Rep, 2021
Chang CY, Wu KL, Chang YY, Tsai PH, Hung JY, Chang WA, Jian SF, Huang YC, Chong IW, Tsai YM, Hsu YL.   +10 more
europepmc   +3 more sources

Transient kinetics of copper-containing lentil (Lens culinaris) seedling amine oxidase [PDF]

Biochemical Journal, 1985
The reaction between lentil (Lens culinaris) seedling amine oxidase and its chromogenic substrate, p-dimethylaminomethylbenzylamine, has been studied by the stopped-flow technique. Upon being mixed with substrate in the absence of oxygen, the enzyme is bleached in a complex kinetic process.
Andrea Bellelli, Maurizio Brunori, Alessandro Finazzi‐Agrò, Giovanni Floris, A Giartosi, Andrea C. Rinaldi   +5 more
openalex   +5 more sources

Alkylamino Derivatives of 4-Aminomethylpyridine as Inhibitors of Copper-Containing Amine Oxidases

Journal of Medicinal Chemistry, 2005
The first substratelike, reversible inhibitors of different copper amine oxidases (CAOs) with IC50 (M) as low as 2.0 x 10(-8) corresponding to derivatives of 4-aminomethylpyridine with alkoxy (1a-d), alkylthio (2a,b), and alkylamino (3a-e, 4a-j) groups in the positions 3 and 5 have been prepared and studied.
Vincenzo Bertini, F. Buffoni, G. Ignesti, Nevio Picci, Sonia Trombino, Francesca Iemma, Silvana Alfei, Marco Pocci, Francesco Lucchesini, Angela De Munno   +9 more
openalex   +5 more sources

Amine Oxidase, Copper Containing 3 (Aoc3) Knockout Mice Are More Prone to DSS-induced Colitis and Colonic Tumorigenesis. [PDF]

In Vivo
Özcan Ö, Akyol Ö, Akyol A.
europepmc   +3 more sources

Time-Series Structural Studies of Topaquinone Biogenesis in Copper Containing Amine Oxidase

Nihon Kessho Gakkaishi, 2003
Copper-containing amine oxidase contains a covalently bound organic cofactor, 2, 4, 5-trihydroxyphenylalanine (topa) quinone, which is formed by post-translational modification of a specific tyrosine residue in the presence of copper ion and oxygen molecule. Apo-enzyme crystals were anaerobically soaked in the mother liquor that contains copper ion and
Hiroshi Yamaguchi, Misa Kim
openalex   +3 more sources