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Amino Acids and Inherited Amino Acid-Related Disorders [PDF]
Journal of Nutrition and Metabolism, 2018 Amino acids perform multiple essential physiological roles in humans, and accordingly, their importance to health has been the subject of extensive attention. In this special issue of the Journal of Nutrition and Metabolism, we focus on the various inborn errors of amino acid metabolism, their diagnostic challenges, new treatment approaches, and recent
Ina Knerr +4 more
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Rush Hour of LATs towards Their Transport Cycle
Membranes, 2021 The mammalian SLC7 family comprises the L-amino acid transporters (LATs) and the cationic amino acid transporters (CATs). The relevance of these transporters is highlighted by their involvement in several human pathologies, including inherited rare ...
Adrià Nicolàs-Aragó +3 more
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Amino acid metabolism in health and disease
Signal Transduction and Targeted Therapy, 2023 Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth, differentiation and function.
Zhe-Nan Ling +5 more
semanticscholar +1 more source
Membrane Protein Stabilization Strategies for Structural and Functional Studies
Membranes, 2021 Accounting for nearly two-thirds of known druggable targets, membrane proteins are highly relevant for cell physiology and pharmacology. In this regard, the structural determination of pharmacologically relevant targets would facilitate the intelligent ...
Ekaitz Errasti-Murugarren +2 more
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The Ectodomains of rBAT and 4F2hc Are Fake or Orphan α-Glucosidases
Molecules, 2021 It is known that 4F2hc and rBAT are the heavy subunits of the heteromeric amino acid transporters (HATs). These heavy subunits are N-glycosylated proteins, with an N-terminal domain, one transmembrane domain and a bulky extracellular domain (ectodomain ...
Joana Fort +2 more
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Frontiers in Physiology, 2023 An 8-week feeding trial was conducted to evaluate the effects of L-methionine and methionine hydroxy analogue calcium (MHA-Ca) supplements in low-fishmeal diet on growth performance, hepatopancreas morphology, protein metabolism, anti-oxidative capacity,
Lu Zheng +9 more
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Frontiers in Immunology, 2023 Comparative animal models generate fundamental scientific knowledge of immune responses. However, these studies typically are conducted in mammals because of their biochemical and physiological similarity to humans.
Karina L. Hissen +4 more
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Multiple rereads of single proteins at single–amino acid resolution using nanopores
Science, 2021 Description Reading amino acids by nanopore Nanopore technology enables sensing of minute chemical changes at the single-molecule level by detecting differences in an ion current as molecules are drawn through a membrane-embedded pore. The sensitivity is
H. Brinkerhoff +4 more
semanticscholar +1 more source
Frontiers in Plant Science, 2020 Staple crops in human and livestock diets suffer from deficiencies in certain “essential” amino acids including methionine. With the goal of increasing methionine in rice seed, we generated a pair of “Push × Pull” double transgenic lines, each containing
Sarah J. Whitcomb +8 more
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Experimental & Molecular Medicine, 2020 AbstractOver 90 years ago, Otto Warburg’s seminal discovery of aerobic glycolysis established metabolic reprogramming as one of the first distinguishing characteristics of cancer1. The field of cancer metabolism subsequently revealed additional metabolic alterations in cancer by focusing on central carbon metabolism, including the citric acid cycle and
Elizabeth L. Lieu +3 more
openaire +4 more sources