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Distances and classification of amino acids for different protein secondary structures [PDF]

PRE 67,051927 (2003), 2002
Window profiles of amino acids in protein sequences are taken as a description of the amino acid environment. The relative entropy or Kullback-Leibler distance derived from profiles is used as a measure of dissimilarity for comparison of amino acids and secondary structure conformations.
J. Garnier, Li-mei Zhang, O. Weiss, O. Weiss, P. Stolorz, S. Henikoff, Shan Guan, U. Hobohm, W. Kabsch, Wei-Mou Zheng, Xin Liu   +10 more
arxiv   +4 more sources

Amino Acids and Inherited Amino Acid-Related Disorders [PDF]

Journal of Nutrition and Metabolism, 2018
Amino acids perform multiple essential physiological roles in humans, and accordingly, their importance to health has been the subject of extensive attention. In this special issue of the Journal of Nutrition and Metabolism, we focus on the various inborn errors of amino acid metabolism, their diagnostic challenges, new treatment approaches, and recent
Ina Knerr, Laurie Bernstein, Ellen Crushell, Siobhan O’Sullivan, Jörn Oliver Sass   +4 more
doaj   +4 more sources

Amino acid metabolism conflicts with protein diversity [PDF]

arXiv, 2014
The twenty protein coding amino acids are found in proteomes with different relative abundances. The most abundant amino acid, leucine, is nearly an order of magnitude more prevalent than the least abundant amino acid, cysteine. Amino acid metabolic costs differ similarly, constraining their incorporation into proteins.
Alonso, Leonardo G., Ferreiro, Diego U., Krick, Teresa, Sanchez, Ignacio E., Shub, David A., Shub, Michael, Verstraete, Nina   +6 more
arxiv   +7 more sources

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor [PDF]

Nature Communications, 2016
Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood.
Abigail S. Krall, Shili Xu, T. Graeber, D. Braas, H. Christofk   +4 more
semanticscholar   +3 more sources

Amino acid requirements of the infant: the amino acid composition of human breast milk [PDF]

Frontiers in Nutrition
The recommended amino acid requirements of the infant are based on the amino acid composition of mature human breast milk. The amino acid composition of breast milk is usually determined following either acid or alkaline (for tryptophan) hydrolysis.
Paul J. Moughan, Amelie Deglaire, Yalu Yan, Philip Wescombe, Philip Wescombe, Wen Xin Janice Lim, Natascha Stroebinger, Sufang Duan, Ignatius Man-Yau Szeto, Ignatius Man-Yau Szeto, Suzanne Hodgkinson   +10 more
doaj   +2 more sources

A thermodynamic basis for prebiotic amino acid synthesis and the nature of the first genetic code [PDF]

, 2009
Of the twenty amino acids used in proteins, ten were formed in Miller's atmospheric discharge experiments. The two other major proposed sources of prebiotic amino acid synthesis include formation in hydrothermal vents and delivery to Earth via meteorites.
Chakrabarti S., Paul G. Higgs, Ralph E. Pudritz   +2 more
arxiv   +3 more sources

A sulfur amino acid deficiency changes the amino acid composition of body protein in piglets [PDF]

Animal, 2010
Experiments carried out to determine the amino acid requirement in growing animals are often based on the premise that the amino acid composition of body protein is constant. However, there are indications that this assumption may not be correct.
J.A. Conde-Aguilera, R. Barea, N. Le Floc’h, L. Lefaucheur, J. van Milgen   +4 more
doaj   +3 more sources

Rush Hour of LATs towards Their Transport Cycle

Membranes, 2021
The mammalian SLC7 family comprises the L-amino acid transporters (LATs) and the cationic amino acid transporters (CATs). The relevance of these transporters is highlighted by their involvement in several human pathologies, including inherited rare ...
Adrià Nicolàs-Aragó, Joana Fort, Manuel Palacín, Ekaitz Errasti-Murugarren   +3 more
doaj   +1 more source

Membrane Protein Stabilization Strategies for Structural and Functional Studies

Membranes, 2021
Accounting for nearly two-thirds of known druggable targets, membrane proteins are highly relevant for cell physiology and pharmacology. In this regard, the structural determination of pharmacologically relevant targets would facilitate the intelligent ...
Ekaitz Errasti-Murugarren, Paola Bartoccioni, Manuel Palacín   +2 more
doaj   +1 more source

The Ectodomains of rBAT and 4F2hc Are Fake or Orphan α-Glucosidases

Molecules, 2021
It is known that 4F2hc and rBAT are the heavy subunits of the heteromeric amino acid transporters (HATs). These heavy subunits are N-glycosylated proteins, with an N-terminal domain, one transmembrane domain and a bulky extracellular domain (ectodomain ...
Joana Fort, Adrià Nicolàs-Aragó, Manuel Palacín   +2 more
doaj   +1 more source