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Amino Acids and Inherited Amino Acid-Related Disorders [PDF]

Journal of Nutrition and Metabolism, 2018
Amino acids perform multiple essential physiological roles in humans, and accordingly, their importance to health has been the subject of extensive attention. In this special issue of the Journal of Nutrition and Metabolism, we focus on the various inborn errors of amino acid metabolism, their diagnostic challenges, new treatment approaches, and recent
Ina Knerr, Laurie Bernstein, Ellen Crushell, Siobhan O’Sullivan, Jörn Oliver Sass   +4 more
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Amino acid requirements of the infant: the amino acid composition of human breast milk [PDF]

Frontiers in Nutrition
The recommended amino acid requirements of the infant are based on the amino acid composition of mature human breast milk. The amino acid composition of breast milk is usually determined following either acid or alkaline (for tryptophan) hydrolysis.
Paul J. Moughan, Amelie Deglaire, Yalu Yan, Philip Wescombe, Philip Wescombe, Wen Xin Janice Lim, Natascha Stroebinger, Sufang Duan, Ignatius Man-Yau Szeto, Ignatius Man-Yau Szeto, Suzanne Hodgkinson   +10 more
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Rush Hour of LATs towards Their Transport Cycle

Membranes, 2021
The mammalian SLC7 family comprises the L-amino acid transporters (LATs) and the cationic amino acid transporters (CATs). The relevance of these transporters is highlighted by their involvement in several human pathologies, including inherited rare ...
Adrià Nicolàs-Aragó, Joana Fort, Manuel Palacín, Ekaitz Errasti-Murugarren   +3 more
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Membrane Protein Stabilization Strategies for Structural and Functional Studies

Membranes, 2021
Accounting for nearly two-thirds of known druggable targets, membrane proteins are highly relevant for cell physiology and pharmacology. In this regard, the structural determination of pharmacologically relevant targets would facilitate the intelligent ...
Ekaitz Errasti-Murugarren, Paola Bartoccioni, Manuel Palacín   +2 more
doaj   +1 more source

The Ectodomains of rBAT and 4F2hc Are Fake or Orphan α-Glucosidases

Molecules, 2021
It is known that 4F2hc and rBAT are the heavy subunits of the heteromeric amino acid transporters (HATs). These heavy subunits are N-glycosylated proteins, with an N-terminal domain, one transmembrane domain and a bulky extracellular domain (ectodomain ...
Joana Fort, Adrià Nicolàs-Aragó, Manuel Palacín   +2 more
doaj   +1 more source

Comparative study on the effects of crystalline L-methionine and methionine hydroxy analogue calcium supplementations in the diet of juvenile Pacific white shrimp (Litopenaeus vannamei)

Frontiers in Physiology, 2023
An 8-week feeding trial was conducted to evaluate the effects of L-methionine and methionine hydroxy analogue calcium (MHA-Ca) supplements in low-fishmeal diet on growth performance, hepatopancreas morphology, protein metabolism, anti-oxidative capacity,
Lu Zheng, Yuechong Liu, Yanmei Zhang, Bingying Xu, Gladstone Sagada, Zhixuan Wang, Cong Chen, Xiandong Lang, Jiaonan Zhang, Qingjun Shao   +9 more
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Immunonutrition: facilitating mucosal immune response in teleost intestine with amino acids through oxidant-antioxidant balance

Frontiers in Immunology, 2023
Comparative animal models generate fundamental scientific knowledge of immune responses. However, these studies typically are conducted in mammals because of their biochemical and physiological similarity to humans.
Karina L. Hissen, Wenliang He, Guoyao Wu, Michael F. Criscitiello, Michael F. Criscitiello   +4 more
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Cysteine and Methionine Biosynthetic Enzymes Have Distinct Effects on Seed Nutritional Quality and on Molecular Phenotypes Associated With Accumulation of a Methionine-Rich Seed Storage Protein in Rice

Frontiers in Plant Science, 2020
Staple crops in human and livestock diets suffer from deficiencies in certain “essential” amino acids including methionine. With the goal of increasing methionine in rice seed, we generated a pair of “Push × Pull” double transgenic lines, each containing
Sarah J. Whitcomb, Apidet Rakpenthai, Franziska Brückner, Axel Fischer, Saroj Parmar, Alexander Erban, Joachim Kopka, Malcolm J. Hawkesford, Rainer Hoefgen   +8 more
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Amino acids in cancer [PDF]

Experimental & Molecular Medicine, 2020
AbstractOver 90 years ago, Otto Warburg’s seminal discovery of aerobic glycolysis established metabolic reprogramming as one of the first distinguishing characteristics of cancer1. The field of cancer metabolism subsequently revealed additional metabolic alterations in cancer by focusing on central carbon metabolism, including the citric acid cycle and
Elizabeth L. Lieu, Jiyeon Kim, Tu Nguyen, Shawn Rhyne   +3 more
openaire   +4 more sources

Quinone-amino acid conjugates targeting Leishmania amino acid transporters. [PDF]

PLoS ONE, 2014
The aim of the present study was to investigate the feasibility of targeting Leishmania transporters via appropriately designed chemical probes. Leishmania donovani, the parasite that causes visceral leishmaniasis, is auxotrophic for arginine and lysine ...
Federica Prati, Adele Goldman-Pinkovich, Federica Lizzi, Federica Belluti, Roni Koren, Dan Zilberstein, Maria Laura Bolognesi   +6 more
doaj   +1 more source