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Brain amino acid sensing for organismal amino acid homeostasis [PDF]

Open Biology
Amino acids are essential for normal physiological functions, and disruptions in their circulating concentrations are implicated in the pathophysiology of various diseases.
Anthony H. Tsang, Liubou Samson, Clemence Blouet   +2 more
doaj   +2 more sources

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor [PDF]

Nature Communications, 2016
Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood.
Abigail S. Krall, Shili Xu, T. Graeber, D. Braas, H. Christofk   +4 more
semanticscholar   +3 more sources

Rush Hour of LATs towards Their Transport Cycle

Membranes, 2021
The mammalian SLC7 family comprises the L-amino acid transporters (LATs) and the cationic amino acid transporters (CATs). The relevance of these transporters is highlighted by their involvement in several human pathologies, including inherited rare ...
Adrià Nicolàs-Aragó, Joana Fort, Manuel Palacín, Ekaitz Errasti-Murugarren   +3 more
doaj   +1 more source

Membrane Protein Stabilization Strategies for Structural and Functional Studies

Membranes, 2021
Accounting for nearly two-thirds of known druggable targets, membrane proteins are highly relevant for cell physiology and pharmacology. In this regard, the structural determination of pharmacologically relevant targets would facilitate the intelligent ...
Ekaitz Errasti-Murugarren, Paola Bartoccioni, Manuel Palacín   +2 more
doaj   +1 more source

The Ectodomains of rBAT and 4F2hc Are Fake or Orphan α-Glucosidases

Molecules, 2021
It is known that 4F2hc and rBAT are the heavy subunits of the heteromeric amino acid transporters (HATs). These heavy subunits are N-glycosylated proteins, with an N-terminal domain, one transmembrane domain and a bulky extracellular domain (ectodomain ...
Joana Fort, Adrià Nicolàs-Aragó, Manuel Palacín   +2 more
doaj   +1 more source

Amino acid metabolism in health and disease

Signal Transduction and Targeted Therapy, 2023
Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth, differentiation and function.
Zhe-Nan Ling, Yi-Fan Jiang, Junnan Ru, Jia-Hua Lu, Bo Ding, Jian Wu   +5 more
semanticscholar   +1 more source

Comparative study on the effects of crystalline L-methionine and methionine hydroxy analogue calcium supplementations in the diet of juvenile Pacific white shrimp (Litopenaeus vannamei)

Frontiers in Physiology, 2023
An 8-week feeding trial was conducted to evaluate the effects of L-methionine and methionine hydroxy analogue calcium (MHA-Ca) supplements in low-fishmeal diet on growth performance, hepatopancreas morphology, protein metabolism, anti-oxidative capacity,
Lu Zheng, Yuechong Liu, Yanmei Zhang, Bingying Xu, Gladstone Sagada, Zhixuan Wang, Cong Chen, Xiandong Lang, Jiaonan Zhang, Qingjun Shao   +9 more
doaj   +1 more source

Immunonutrition: facilitating mucosal immune response in teleost intestine with amino acids through oxidant-antioxidant balance

Frontiers in Immunology, 2023
Comparative animal models generate fundamental scientific knowledge of immune responses. However, these studies typically are conducted in mammals because of their biochemical and physiological similarity to humans.
Karina L. Hissen, Wenliang He, Guoyao Wu, Michael F. Criscitiello, Michael F. Criscitiello   +4 more
doaj   +1 more source

Multiple rereads of single proteins at single–amino acid resolution using nanopores

Science, 2021
Description Reading amino acids by nanopore Nanopore technology enables sensing of minute chemical changes at the single-molecule level by detecting differences in an ion current as molecules are drawn through a membrane-embedded pore. The sensitivity is
H. Brinkerhoff, Albert S. W. Kang, Jingqian Liu, A. Aksimentiev, C. Dekker   +4 more
semanticscholar   +1 more source

Cysteine and Methionine Biosynthetic Enzymes Have Distinct Effects on Seed Nutritional Quality and on Molecular Phenotypes Associated With Accumulation of a Methionine-Rich Seed Storage Protein in Rice

Frontiers in Plant Science, 2020
Staple crops in human and livestock diets suffer from deficiencies in certain “essential” amino acids including methionine. With the goal of increasing methionine in rice seed, we generated a pair of “Push × Pull” double transgenic lines, each containing
Sarah J. Whitcomb, Apidet Rakpenthai, Franziska Brückner, Axel Fischer, Saroj Parmar, Alexander Erban, Joachim Kopka, Malcolm J. Hawkesford, Rainer Hoefgen   +8 more
doaj   +1 more source