Results 1 to 10 of about 268,018 (222)

Rush Hour of LATs towards Their Transport Cycle

Membranes, 2021
The mammalian SLC7 family comprises the L-amino acid transporters (LATs) and the cationic amino acid transporters (CATs). The relevance of these transporters is highlighted by their involvement in several human pathologies, including inherited rare ...
Adrià Nicolàs-Aragó, Joana Fort, Manuel Palacín, Ekaitz Errasti-Murugarren   +3 more
doaj   +1 more source

Membrane Protein Stabilization Strategies for Structural and Functional Studies

Membranes, 2021
Accounting for nearly two-thirds of known druggable targets, membrane proteins are highly relevant for cell physiology and pharmacology. In this regard, the structural determination of pharmacologically relevant targets would facilitate the intelligent ...
Ekaitz Errasti-Murugarren, Paola Bartoccioni, Manuel Palacín   +2 more
doaj   +1 more source

The Ectodomains of rBAT and 4F2hc Are Fake or Orphan α-Glucosidases

Molecules, 2021
It is known that 4F2hc and rBAT are the heavy subunits of the heteromeric amino acid transporters (HATs). These heavy subunits are N-glycosylated proteins, with an N-terminal domain, one transmembrane domain and a bulky extracellular domain (ectodomain ...
Joana Fort, Adrià Nicolàs-Aragó, Manuel Palacín   +2 more
doaj   +1 more source

Comparative study on the effects of crystalline L-methionine and methionine hydroxy analogue calcium supplementations in the diet of juvenile Pacific white shrimp (Litopenaeus vannamei)

Frontiers in Physiology, 2023
An 8-week feeding trial was conducted to evaluate the effects of L-methionine and methionine hydroxy analogue calcium (MHA-Ca) supplements in low-fishmeal diet on growth performance, hepatopancreas morphology, protein metabolism, anti-oxidative capacity,
Lu Zheng, Yuechong Liu, Yanmei Zhang, Bingying Xu, Gladstone Sagada, Zhixuan Wang, Cong Chen, Xiandong Lang, Jiaonan Zhang, Qingjun Shao   +9 more
doaj   +1 more source

Immunonutrition: facilitating mucosal immune response in teleost intestine with amino acids through oxidant-antioxidant balance

Frontiers in Immunology, 2023
Comparative animal models generate fundamental scientific knowledge of immune responses. However, these studies typically are conducted in mammals because of their biochemical and physiological similarity to humans.
Karina L. Hissen, Wenliang He, Guoyao Wu, Michael F. Criscitiello, Michael F. Criscitiello   +4 more
doaj   +1 more source

Cysteine and Methionine Biosynthetic Enzymes Have Distinct Effects on Seed Nutritional Quality and on Molecular Phenotypes Associated With Accumulation of a Methionine-Rich Seed Storage Protein in Rice

Frontiers in Plant Science, 2020
Staple crops in human and livestock diets suffer from deficiencies in certain “essential” amino acids including methionine. With the goal of increasing methionine in rice seed, we generated a pair of “Push × Pull” double transgenic lines, each containing
Sarah J. Whitcomb, Apidet Rakpenthai, Franziska Brückner, Axel Fischer, Saroj Parmar, Alexander Erban, Joachim Kopka, Malcolm J. Hawkesford, Rainer Hoefgen   +8 more
doaj   +1 more source

Quinone-amino acid conjugates targeting Leishmania amino acid transporters. [PDF]

PLoS ONE, 2014
The aim of the present study was to investigate the feasibility of targeting Leishmania transporters via appropriately designed chemical probes. Leishmania donovani, the parasite that causes visceral leishmaniasis, is auxotrophic for arginine and lysine ...
Federica Prati, Adele Goldman-Pinkovich, Federica Lizzi, Federica Belluti, Roni Koren, Dan Zilberstein, Maria Laura Bolognesi   +6 more
doaj   +1 more source

Unnatural Amino Acid: 4-Aminopyrazolonyl Amino Acid Comprising Tri-Peptides Forms Organogel With Co-Solvent (EtOAc:Hexane)

Frontiers in Chemistry, 2022
Ampyrone is an amino-functionalized heterocyclic pyrazolone derivative that possesses therapeutic values such as analgesic, anti-inflammatory, and antipyretics.
Amarnath Bollu, Amarnath Bollu, Prajnanandan Giri, Prajnanandan Giri, Nihar Ranjan Dalabehera, Nihar Ranjan Dalabehera, Asmita Rani Asmi, Asmita Rani Asmi, Nagendra K. Sharma, Nagendra K. Sharma   +9 more
doaj   +1 more source

Amino acid impact factor. [PDF]

PLoS ONE, 2018
Amino acid mutations in proteins are random and those mutations which are beneficial or neutral survive during the course of evolution. Conservation or co-evolution analyses are performed on the multiple sequence alignment of homologous proteins to ...
C K Sruthi, Meher Prakash
doaj   +1 more source

Incorporation of Unnatural Amino Acid into Antibody Fragment for Creating a Stable Antibody Drug Conjugate

Indonesian Journal of Pharmacy, 2021
The traditional chemotherapy drug has been used as a standard cancer treatment, however it has resulted a modest survival benefit and damaged non-cancerous cells.
Andri Wardiana, Martina L Jones, Stephen M Mahler, Christopher B Howard   +3 more
doaj   +1 more source