Results 31 to 40 of about 7,986,817 (400)
Predicting the Functional Effect of Amino Acid Substitutions and Indels
PLoS ONE, 2012 As next-generation sequencing projects generate massive genome-wide sequence variation data, bioinformatics tools are being developed to provide computational predictions on the functional effects of sequence variations and narrow down the search of ...
Yongwook Choi +4 more
semanticscholar +1 more source
Learning the Hydrophilic, Hydrophobic and Aromatic Character of Amino Acids from their Interfacial Thermal Conductance in Water [PDF]
, 2021 In this study, the thermal relaxation of the 20 naturally occurring amino-acids in water is investigated using transient non-equilibrium molecular-dynamics simulations. By modeling the thermal relaxation process, the relaxation times of the amino-acids in water occurs over a timescale covering 2-5 ps.
arxiv +1 more source
PROVEAN web server: a tool to predict the functional effect of amino acid substitutions and indels
Bioinform., 2015 UNLABELLED We present a web server to predict the functional effect of single or multiple amino acid substitutions, insertions and deletions using the prediction tool PROVEAN. The server provides rapid analysis of protein variants from any organisms, and
Yongwook Choi, A. Chan
semanticscholar +1 more source
Electron Attachment to DNA: The Protective Role of Amino Acids [PDF]
, 2022 We have studied the effect of amino acids on electron attachment properties of DNA nucleobases, taking cytosine as a model system. The equation of motion coupled cluster theory with an extended basis set has been used to simulate the electron-attached state of the DNA model system. Four selected amino acids, Arginine, Alanine, Lysine, and Glycine which
arxiv +1 more source
Journal of Chemical Theory and Computation, 2019 Molecular dynamics (MD) simulations have become increasingly popular in studying the motions and functions of biomolecules. The accuracy of the simulation, however, is highly determined by the molecular mechanics (MM) force field (FF), a set of functions
Chuan Tian +10 more
semanticscholar +1 more source
Research progress on branched-chain amino acid aminotransferases
Frontiers in Genetics, 2023 Branched-chain amino acid aminotransferases, widely present in natural organisms, catalyze bidirectional amino transfer between branched-chain amino acids and branched-chain α-ketoacids in cells.
Can Chen +3 more
doaj +1 more source
Frontiers in Immunology, 2020 Cardiovascular disease is the leading global health concern and responsible for more deaths worldwide than any other type of disorder. Atherosclerosis is a chronic inflammatory disease in the arterial wall, which underpins several types of cardiovascular
Bozidarka L. Zaric +8 more
doaj +1 more source
Symmetry Scheme for Amino Acid Codons [PDF]
Phys.Rev.E65, 021912 (2002), 2003 Group theoretical concepts are invoked in a specific model to explain how only twenty amino acids occur in nature out of a possible sixty four. The methods we use enable us to justify the occurrence of the recently discovered twenty first amino acid selenocysteine, and also enables us to predict the possible existence of two more, as yet undiscovered ...
arxiv +1 more source
Synthesis and reactivity of 4-oxo-5-trimethylsilanyl derived α-amino acids [PDF]
, 2015 A Lewis-acid promoted one-carbon homologation of an aspartic acid semialdehyde with trimethylsilyldiazomethane has led to the efficient synthesis of two silicon-containing α-amino acids.
Adamczyk +70 more
core +1 more source
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
Science, 2008 The multiprotein mTORC1 protein kinase complex is the central component of a pathway that promotes growth in response to insulin, energy levels, and amino acids and is deregulated in common cancers.
Y. Sancak +6 more
semanticscholar +1 more source