Results 31 to 40 of about 7,026,669 (342)

Predicting deleterious amino acid substitutions.

Genome Research, 2001
Many missense substitutions are identified in single nucleotide polymorphism (SNP) data and large-scale random mutagenesis projects. Each amino acid substitution potentially affects protein function. We have constructed a tool that uses sequence homology
P. Ng, S. Henikoff
semanticscholar   +1 more source

Amino Acid Metabolism in Lupus

Frontiers in Immunology, 2021
T cell metabolism is central to cell proliferation, survival, differentiation, and aberrations have been linked to the pathophysiology of systemic autoimmune diseases.
Michihito Kono, Nobuya Yoshida, George C. Tsokos   +2 more
doaj   +1 more source

An improved general amino acid replacement matrix.

Molecular biology and evolution, 2008
Amino acid replacement matrices are an essential basis of protein phylogenetics. They are used to compute substitution probabilities along phylogeny branches and thus the likelihood of the data. They are also essential in protein alignment.
S. Le, O. Gascuel
semanticscholar   +1 more source

Prediction of protein antigenic determinants from amino acid sequences.

Proceedings of the National Academy of Sciences of the United States of America, 1981
A method is presented for locating protein antigenic determinants by analyzing amino acid sequences in order to find the point of greatest local hydrophilicity.
T. Hopp, K. R. Woods
semanticscholar   +1 more source

Bayes empirical bayes inference of amino acid sites under positive selection.

Molecular biology and evolution, 2005
Codon-based substitution models have been widely used to identify amino acid sites under positive selection in comparative analysis of protein-coding DNA sequences.
Ziheng Yang, Wendy S. W. Wong, R. Nielsen   +2 more
semanticscholar   +1 more source

Physiology of the Amino Acids [PDF]

Science, 1942
We have followed the amino acids from their entrance into the alimentary tract in the form of food proteins through the successive steps of digestion, absorption into the blood stream and passage from the blood stream into the tissues, where they are concentrated by some unknown mechanism to many times their concentration in the blood plasma.
openaire   +3 more sources

The role of amino acid metabolism during abiotic stress release.

Plant, Cell and Environment, 2019
Plant responses to abiotic stress include various modifications in amino acid metabolism. By using a hydroponic culture system, we systematically investigate modification in amino acid profiles and the proteome of Arabidopsis thaliana leaves during ...
Willian Batista-Silva, Björn Heinemann, Nils Rugen, A. Nunes‐Nesi, W. Araújo, H. Braun, Tatjana M. Hildebrandt   +6 more
semanticscholar   +1 more source

An Evaluation of the Arginine Requirements of Broiler Chickens and the Potential Arginine and Energy-Saving Effects of Guanidinoacetic Acid

Animals
Two 35-day trials were conducted to determine the arginine (Arg) requirement of broiler chickens and the Arg and energy-sparing effects of guanidinoacetic acid (GAA). In experiment 1, a low-Arg diet (basal diet) was supplemented with increasing levels (0.
Adriaan Verhelle, Behnam Saremi
doaj   +1 more source

Research Progress of Amino Acid Metabolism PET Imaging in Tumor

Journal of Isotopes, 2015
Amino acid metabolism PET imaging plays a very important role in metabolism molecular imaging. Amino acid PET tracers include ［1-11C］amino acid, labeling α-C amino acid, labeling side-chain amino acid, and N-substituted labeling amino acid.
NIE Da-hong, TANG Gang-hua2
doaj   +1 more source

A classification of glycosyl hydrolases based on amino acid sequence similarities.

Biochemical Journal, 1991
The amino acid sequences of 301 glycosyl hydrolases and related enzymes have been compared. A total of 291 sequences corresponding to 39 EC entries could be classified into 35 families.
B. Henrissat
semanticscholar   +1 more source