Results 61 to 70 of about 7,026,669 (342)
Amino acid homeostasis and signalling in mammalian cells and organisms
Biochemical Journal, 2017 Cells have a constant turnover of proteins that recycle most amino acids over time. Net loss is mainly due to amino acid oxidation. Homeostasis is achieved through exchange of essential amino acids with non-essential amino acids and the transfer of amino
S. Bröer, A. Bröer
semanticscholar +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Communications Biology, 2022 Amino acid deprivation increases ACE2 expression in the gut, potentially aggravating SARS-CoV-2 infection.
Xiaoming Hu +7 more
doaj +1 more source
Phenotypic characteristics of black apricot Prunus × dasycarpa cultivar ‘Shlor-Tsiran’ in Armenia
Folia Horticulturae‘Shlor-Tsiran’ (literally called ‘Plum-Apricot’) is an old black apricot cultivar, which is traditionally cultivated in Armenia. Taxonomically, it belongs to Prunus × dasycarpa Ehrh., which is a spontaneous hybrid of apricot and cherry plum (P. armeniaca
Akopian Janna +5 more
doaj +1 more source
Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
Nature Communications, 2016 Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood.
Abigail S. Krall +4 more
semanticscholar +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
PLoS ONE, 2022 For pollinators such as bees, nectar mainly provides carbohydrates and pollen provides proteins, amino acids, and lipids to cover their nutritional needs. Here, to examine differences in pollinator resources, we compared the amino acid profiles and total
Léna Jeannerod +7 more
doaj +1 more source
Amino Acids, Amino Acid Derivatives and Peptides as Antioxidants
, 2022 [Excerpt] The biological concept of antioxidant refers to any compound that is able to delay or 5 prevent the oxidation of easily oxidizable substrates, such as DNA, proteins and 6 lipids. Antioxidants reduce oxidative stress and mutations in DNA as well as other 7 parameters associated with cell damage.
Monteiro, Luís S. +1 more
openaire +2 more sources