Results 91 to 100 of about 33,968 (291)

Folding of a single domain protein entering the endoplasmic reticulum precedes disulfide formation [PDF]

, 2017
The relationship between protein synthesis, folding and disulfide formation within the endoplasmic reticulum (ER) is poorly understood. Previous studies have suggested pre-existing disulfide links are absolutely required to allow protein folding and ...
Bulleid, Neil J., Pringle, Marie Anne, Robinson, Philip J., Woolhead, Cheryl A.   +3 more
core   +1 more source

MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity

Advanced Science, EarlyView.
During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen, Paili Lin, Yongfang Xia, Zhiqiang Liu, Zilu Cheng, Qingmei Zhu, Shiqi Wan, Xiaoyu Chen, Haiyan Bao, Renbo Qiao, Gechang Zhong, Ying Zhu, Shi Liu   +12 more
wiley   +1 more source

Novel insights into the somatic proteome of Strongyloides stercoralis infective third-stage larvae

Parasites & Vectors, 2023
Background Strongyloidiasis is a neglected tropical disease affecting an estimated 600 million people, particularly in resource-limited settings. The infection can persist lifelong due to unusual auto-infective cycle of Strongyloides stercoralis.
Klevia Dishnica, Chiara Piubelli, Marcello Manfredi, Ravi Teja Kondaveeti, Silvia Stefania Longoni, Monica Degani, Dora Buonfrate, Alejandro Giorgetti, Natalia Tiberti   +8 more
doaj   +1 more source

Metabolic network analysis reveals microbial community interactions in anammox granules. [PDF]

, 2017
Microbial communities mediating anaerobic ammonium oxidation (anammox) represent one of the most energy-efficient environmental biotechnologies for nitrogen removal from wastewater.
Bhattacharjee, Ananda S, Goel, Ramesh, Hamilton, Joshua J, Lawson, Christopher E, McMahon, Katherine D, Noguera, Daniel R, Wu, Sha   +6 more
core   +2 more sources

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, EarlyView.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source

Integrated multi-omics reveal the multidimensional mechanisms of Penicillium sp. in selenite biodegradation

Ecotoxicology and Environmental Safety
Bioremediation is a green and efficient strategy for detoxifying toxic metalloids like selenite. However, the molecular mechanisms underlying microbially driven selenite transformation are still not fully understood.
Yexing Tao, Dandan Yi, Yalijuan Wu, Guangai Deng, Zhiyong Wang, Mu Peng   +5 more
doaj   +1 more source

Rapid Proteome‐Wide Discovery of Protein–Protein Interactions With ppIRIS

Advanced Science, EarlyView.
ppIRIS is a lightweight deep learning framework for proteome‐wide protein–protein interaction prediction directly from sequence. By fusing evolutionary and structural embeddings with a regularized Siamese architecture, ppIRIS achieves state‐of‐the‐art accuracy across species, enables minute‐scale screening, and reveals biologically validated bacterial ...
Luiz Felipe Piochi, Di Tang, Johan Malmström, Yasaman Karami, Hamed Khakzad   +4 more
wiley   +1 more source

Clostridium sticklandii, a specialist in amino acid degradation:revisiting its metabolism through its genome sequence

BMC Genomics, 2010
Background Clostridium sticklandii belongs to a cluster of non-pathogenic proteolytic clostridia which utilize amino acids as carbon and energy sources. Isolated by T.C.
Pelletier Eric, Perchat Nadia, Andreesen Jan R, Lajus Aurélie, Tricot Sabine, Chaussonnerie Sébastien, Fonknechten Nuria, Gouyvenoux Michel, Barbe Valérie, Salanoubat Marcel, Le Paslier Denis, Weissenbach Jean, Cohen Georges N, Kreimeyer Annett   +13 more
doaj   +1 more source

Automatically Defining Protein Words for Diverse Functional Predictions Based on Attention Analysis of a Protein Language Model

Advanced Science, EarlyView.
Understanding protein sequence–function relationships remains challenging due to poorly defined motifs and limited residue‐level annotations. An annotation‐agnostic framework is introduced that segments protein sequences into “protein words” using attention patterns from protein language models.
Hedi Chen, Jingrui Zhong, Xiaochun Zhang, Jingke Chen, Lin Guo, Xiaoliang Xiong, Xiaonan Zhang, Xiangyu Liu, Bailong Xiao, Boxue Tian   +9 more
wiley   +1 more source

The effect of different frequencies of ultrasound on the activity of horseradish peroxidase [PDF]

, 2018
Ultrasound technology has been studied by food researchers as an alternative method for thermal processing. The use of ultrasound as a way to inactivate and/or activate enzymes has been widely studied at low frequencies (20–40 kHz), however, little ...
Bremner, David H., Chu, Boon-Seang, Lemos, M. Adilia, Tsikrika, Konstantina   +3 more
core   +2 more sources