Results 161 to 170 of about 24,002 (247)

Synthesis of thermostable artificial nicotinamide cofactors: carba-NAD⁺ and carba-NADP^. [PDF]

RSC Chem Biol
Dsouza Z, Friedrichs JJ, Döring M, Rincón Téllez N, Schmermund L, Sieber V.   +5 more
europepmc   +1 more source

Nitric Oxide in Cancer: Mechanisms, Dual Role, and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Nitric oxide exerts concentration‐dependent dual roles in cancer, functioning as either a tumor promoter or suppressor. This review comprehensively examines NO's multifaceted regulation of tumor biology, including S‐nitrosylation signaling, metabolic reprogramming, immunemodulation, and therapy resistance, and highlights emerging therapeutic strategies
Jia Shao, Honghua Zhang, Jingyu Chen, Ziyu Qian, Ning Zhang, Yihua Zhang, Hui Ye, Jianbing Wu, Zhangjian Huang   +8 more
wiley   +1 more source

On the emergence of metabolism: the evolution of proteins that powered life. [PDF]

Philos Trans R Soc Lond B Biol Sci
Nanda V, Siess J, Jagilinki BP, Hazen RM, Kamerlin SCL, Koder R, Noy D, Silberg J, Tezcan FA, Ulijn R, Yee N, Falkowski P.   +11 more
europepmc   +1 more source

A cofactor‐promiscuous HMGR from the Lyme disease pathogen illuminates diversity in bacterial isoprenoid biosynthesis

Protein Science, Volume 35, Issue 9, September 2026.
Abstract The Lyme disease pathogen Borrelia burgdorferi contains a highly reduced genome lacking many primary metabolic pathways. However, B. burgdorferi retains the mevalonate pathway that synthesizes isopentenyl pyrophosphate (IPP), the precursor to the peptidoglycan carrier lipid.
Isaac A. Paddy, Joshua McCausland, Madelyn Frazier, Poulami Chatterjee, Mekedlawit Setegne, Oliv Eidam, Christine Jacobs‐Wagner, Laura M. K. Dassama   +7 more
wiley   +1 more source

Structural basis of regioselective double halogenation of the β-carboline tryptoline by the single-component halogenase AetF. [PDF]

Acta Crystallogr D Struct Biol
Bork S, Horstmeier HJ, Scharkowski B, Niemann HH.   +3 more
europepmc   +1 more source

The Mycobacterium tuberculosis Rv0132c Gene Product Mtb‐FGD2 Can Act as an F420‐Dependent Glucose Dehydrogenase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 9, Page 1610-1627, September 2026.
ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi, Matthew Snee, Richard B. Tunnicliffe, Linus O. Johanissen, Matthew J. Cliff, Colin W. Levy, Derren J. Heyes, Marina Golovanova, Thomas A. Jowitt, Sam Hay, Andrew W. Munro, Jonathan P. Waltho, David Leys   +12 more
wiley   +1 more source

Proteolytic and non-proteolytic mechanisms of keratin degradation in <i>Onygena corvina</i> revealed by a proteogenomic approach. [PDF]

Appl Environ Microbiol
Pavale S, Isembart C, Shapaval V, Tuveng TR, La Rosa SL, Eijsink VGH.   +5 more
europepmc   +1 more source

Edible Insect Allergens: An Emerging Food Safety Challenge

Sustainable Food Proteins, Volume 4, Issue 3, September 2026.
Allergic responses to edible insects arise via two main pathways: cross‐reactivity with homologous arthropod allergens and primary sensitization to edible insect proteins, both leading to IgE‐mediated immune activation. ABSTRACT Edible insects are increasingly promoted as sustainable protein sources; however, their allergenic potential remains a ...
Changqi Liu, Cassandra Maya, John J. Love, Huilian Che, Ke Chen, Jing Zhao   +5 more
wiley   +1 more source

Crystal structure of Plasmodium vivax macrophage migration inhibitory factor. [PDF]

Acta Crystallogr F Struct Biol Commun
Nair A, Lin M, Srivastava A, Liu L, Cooper A, Battaile K, Harmon E, Myler PJ, Staker BL, Lovell S, Chakafana G, Asojo OA.   +11 more
europepmc   +1 more source

Systematic prioritization of candidate genes in camptothecin biosynthesis using multi‐omics and deep learning

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Camptothecin (CPT), a plant‐derived monoterpene indole alkaloid first identified in Camptotheca acuminata, is a drug precursor widely used for cancer chemotherapeutics. However, the full set of genes responsible for CPT biosynthesis remains unclear, hindering efforts to elucidate the complete pathway or establish biosynthetic production of CPT
Shenqi Wang, Xing Wu, Maria Moreno, Joonseok Oh, Stephen L. Dellaporta, Jason M. Crawford, Farren J. Isaacs   +6 more
wiley   +1 more source