Results 191 to 200 of about 24,002 (247)

Development of novel salicylic acid derivatives with dual anti-inflammatory and anti-arthritic potentials: synthesis, <i>in vitro</i> bio-evaluation, and <i>in silico</i> toxicity prediction with molecular modeling simulations. [PDF]

RSC Adv
Hesham K, Aboulthana WM, Ragab A.
europepmc   +1 more source

Chemotherapeutic Potential of Fluorouracil‐Platinum (IV) Prodrugs Against Cisplatin‐Resistant Colorectal Cancer Cells

Chemistry – A European Journal, Volume 32, Issue 30, 13 August 2026.
ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias, Aleen Khoury, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich‐Wright   +9 more
wiley   +1 more source

Genomic Survey of Carbon Monoxide Dehydrogenases Reveals Their Widespread Distribution in Marine Habitats. [PDF]

Environ Microbiol Rep
Chongdar N, Goyal A, Damare SR.
europepmc   +1 more source

tRNA-deacylase-directed discovery of biosynthetic pathways. [PDF]

Nat Chem
Millar DC, Zhou Y, Marchand JA, Roberts-Mataric H, Chen T, Hu CX, Fang J, Millar S, Stone EA, Pelton JG, Sosa MB, Chang MCY.   +11 more
europepmc   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, Volume 600, Issue 15, Page 2129-2142, August 2026.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Iron-Containing Alcohol Dehydrogenase from Hyperthermophiles. [PDF]

BioTech (Basel)
Tse C, Ma K.
europepmc   +1 more source

The adaptive nature of the foam proteome produced by Mahanarva spectabilis (Hemiptera: Cercopidae) when infesting forage grasses with different levels of antibiosis-type resistance. [PDF]

Sci Rep
José Rinaldi A, Silva Bonjour M, Barros E, Machado Auad A, Teixeira Bhering Faria G, Almeida Oliveira MG, Josué de Oliveira Ramos H, Fernando Pereira J.   +7 more
europepmc   +1 more source

Biocatalytic Application of Goodfellowiella coeruleoviolacea Imine Reductase: Enantioselective Synthesis of Cyclic Secondary Amines in Deep Eutectic Solvent‐Based Media

Advanced Synthesis &Catalysis, Volume 368, Issue 15, 1 August 2026.
A Goodfellowiella coeruleoviolacea Imine Reductase is here reported as a novel enzyme for biocatalytic application in chiral amine synthesis. Deep eutectic solvents have been used to increase substrate loadings, up to 150 mM, and boost enzymatic activity. Reaction scope and scale‐up procedure showcased the protocol applicability.
Federica De Nardi, Alessandro Marchetto, Nicoletta Schiavo, Francesca Spyrakis, Francesca Paradisi, Cristina Prandi   +5 more
wiley   +1 more source

A general approach for activity-based protein profiling of oxidoreductases with redox-differentiated diarylhalonium warheads. [PDF]

Chem Sci
Krammer L, Darnhofer B, Kljajic M, Liesinger L, Schittmayer M, Neshchadin D, Gescheidt G, Kollau A, Mayer B, Fischer RC, Wallner S, Macheroux P, Birner-Gruenberger R, Breinbauer R.   +13 more
europepmc   +1 more source

Advancements in Enzymatic Biofuel Cells for Wearable Electrochemical Biosensors: Powering Point‐of‐Care Health Monitoring

Advanced Sensor Research, Volume 5, Issue 8, August 2026.
Advances in enzymatic biofuel cells are highlighted through innovative electrode architectures, enzyme immobilization strategies, and hybrid integration with triboelectric, piezoelectric, and thermoelectric energy harvesters. These emerging approaches improve power output, operational stability, and biocompatibility, advancing self‐powered wearable and
Rashid Khan, Mohammad Abrar Uddin, Yi Jae Lee, Taeil Kim   +3 more
wiley   +1 more source