Physiologia Plantarum, Volume 178, Issue 2, March/April 2026.ABSTRACT Phytoene desaturase (PDS; EC 1.3.5.5) is a key enzyme of the carotenoid biosynthetic pathway, catalyzing the desaturation of phytoene, precursor of all carotenoids. In this study, several PDS‐knockout (PDS‐KO) transformants of the chlorophyte microalga Chlamydomonas reinhardtii were generated using a reverse genetics strategy. Two single guide
Ana Molina‐Márquez +5 more
wiley +1 more source
Dynamic regulation of receptor-modulated endothelial NADPH oxidases. [PDF]
Proc Natl Acad Sci U S AWaldeck-Weiermair M +12 more
europepmc +1 more source
Role of Septin7 in mitochondrial dynamics and oxidative metabolism in C2C12 skeletal muscle cells
The Journal of Physiology, Volume 604, Issue 5, Page 1971-1994, 1 March 2026.Abstract figure legend Knockdown of Septin7 alters the expression of markers responsible for mitochondrial dynamics. Members of the electron transport chain are also affected by diminished Septin7 level resulting in functional changes of mitochondrial respiration. Abstract Mitochondria are dynamic organelles that undergo fusion and fission.
Andrea Telek +13 more
wiley +1 more source
Rerouting reductant flux via protein tethering enhances biohydrogen production in Thermococcus kodakarensis. [PDF]
Appl Microbiol BiotechnolWilliams SA +6 more
europepmc +1 more source
Direct‐to‐Biology: Streamlining the Path From Chemistry to Biology in Drug Discovery
ChemMedChem, Volume 21, Issue 4, 25 February 2026.Crude yet clever: Direct‐to‐biology workflows exploit nanoscale synthesis and plate‐based assays to accelerate hit discovery, save precious intermediates, and rethink early drug discovery. Direct‐to‐biology (D2B) has emerged as a transformative concept in early drug discovery, defined by the direct on‐target screening of crude reaction mixtures without
Ariane F. Hübner, Fabian Barthels
wiley +1 more source
Polyamine metabolism as a regulator of cellular and organismal aging. [PDF]
Amino AcidsUemura T, Takayama J, Oguro A, Terui Y.
europepmc +1 more source
Biomass‐Derived Diformylxylose as a Renewable Solvent for Biocatalysis Applications
ChemSusChem, Volume 19, Issue 4, 25 February 2026.It feels greener in diformylxylose (DFX)! The renewable solvent dissolves aromatic ketones at remarkable concentrations and sustains the performance of robust enzymes such as ketoreductases (KREDs) and lipases. By combining superior substrate dissolution with improved enzyme performance, DFX offers a green medium for selective, high‐load ...
Fatma Feyza Özgen +4 more
wiley +1 more source
Substrate recognition mechanisms of ʟ-glutamate oxidase from Streptomyces sp. and its conversion to ʟ-tyrosine oxidase. [PDF]
Protein SciUeda Y +5 more
europepmc +1 more source
Unexpected Dual Function of Plant YUCCA Enzymes Links Chlorophyll Catabolism to Auxin Homeostasis
Angewandte Chemie, Volume 138, Issue 9, 23 February 2026.YUCCA enzymes are well known to catalyze the main step of auxin biosynthesis in plants. Here, a hitherto undescribed dual function was discovered, revealing that some YUCCAs also act in chlorophyll degradation. In vitro feedback regulation furthermore suggests a link between chlorophyll degradation and hormone homeostasis and a physiological role of ...
Sina Rütschlin +6 more
wiley +1 more source
Comparative Dynamics Enables Discovery of Embedded Bacterial Ferredoxin Domains in Large Redox Enzymes. [PDF]
ProteinsSiess JA, Nanda V.
europepmc +1 more source