Results 71 to 80 of about 33,968 (291)
Advanced Science, EarlyView.A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding +5 more
wiley +1 more source
Protein thiol modifications visualized in vivo. [PDF]
PLoS Biology, 2004 Thiol-disulfide interconversions play a crucial role in the chemistry of biological systems. They participate in the major systems that control the cellular redox potential and prevent oxidative damage.
Lars I Leichert, Ursula Jakob
doaj +1 more source
A survey of genes encoding H2O2-producing GMC oxidoreductases in 10 Polyporales genomes [PDF]
, 2015 15 p.-4 fig.-1 tab.The genomes of three representative Polyporales (Bjerkandera adusta, Phlebia brevispora and a member of the Ganoderma lucidum complex) recently were sequenced to expand our knowledge on the diversity and distribution of genes involved ...
Carro, Juan +3 more
core +1 more source
Advanced Science, EarlyView.This study reveals the genetic and molecular mechanisms controlling grain size homeostasis through fine‐tuning OsGRX8 self‐expression by two natural negative feedback loops functioning in redox‐dependent or ‐independent manners and identifies two self‐regulatory haplotypes (SRHs) for the subspecies differentiation in rice.
Xingxing Li +13 more
wiley +1 more source
Chemical Proteomics Identifies Ketogenesis‐Mediated Cysteine Modifications Regulating Redox Function
Angewandte Chemie, EarlyView.Herein, we report ketone body induce cysteine modifications beyond lysine acylation, as revealed by integrating chemical proteomics with open‐search methods. Among the modifications, cysteine crotonation (Ccr) was chemically validated by endogenous peptide‐based co‐elution assays.
Yuan‐Fei Zhou +8 more
wiley +2 more sources
Generating functional protein variants with variational autoencoders.
PLoS Computational Biology, 2021 The vast expansion of protein sequence databases provides an opportunity for new protein design approaches which seek to learn the sequence-function relationship directly from natural sequence variation. Deep generative models trained on protein sequence
Alex Hawkins-Hooker +5 more
doaj +1 more source
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2003 Bovine-heart NADH:ubiquinone oxidoreductase (EC 1.6.5.3; Complex I) is the first and most complicated enzyme in the mitochondrial respiratory chain. Biochemistry textbooks and virtually all literature on this enzyme state that it contains one FMN and at least four iron-sulfur clusters.
Albracht, Simon P.J +2 more
openaire +2 more sources
Disulphide production by Ero1alpha-PDI relay is rapid and effectively regulated [PDF]
, 2010 The molecular networks that control endoplasmic reticulum (ER) redox conditions in mammalian cells are incompletely understood. Here, we show that after reductive challenge the ER steady-state disulphide content is restored on a time scale of seconds ...
Appenzeller-Herzog, Christian +6 more
core +2 more sources
Oncolytic Probiotics with Molecular Pili for Solid Tumor Therapy
Advanced Science, EarlyView.This study identifies Lactobacillus rhamnosus as an intrinsic oncolytic agent that triggers tumor metabolic collapse via calcium‐dependent ROS bursts. By chemically anchoring collagen‐targeting “molecular pili” to the bacterial surface, the engineered non‐transgenic probiotic (LR@MP) achieves targeted colonization and potent solid tumor suppression ...
Haodong Ge +14 more
wiley +1 more source
PLOS ONE, 2018 Helicobacter pylori HP0377 is a thiol oxidoreductase, a member of the CcmG family involved in cytochrome biogenesis, as previously shown by in vitro experiments. In this report, we document that HP0377 also acts in vivo in the cytochrome assembly process in Bacillus subtilis, where it complements the lack of ResA.
Magdalena Joanna Grzeszczuk +8 more
openaire +6 more sources