Results 141 to 150 of about 4,987,268 (293)

Serum amino acid concentrations of subjects according to the genetic risk score for HOMA-IR (n = 452).

open access: yes
Serum amino acid concentrations of subjects according to the genetic risk score for HOMA-IR (n = 452).
Liliana Arteaga-Sanchez (17761262)   +23 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Effects of Different Cooking Methods on the Quality and Digestibility of Lipu Taro

open access: yesShipin gongye ke-ji
To explore the effects of cooking methods on the quality and digestibility of Lipu taro, Lipu taro was used as raw material to cooking by four methods including boiling, steaming, pressure cooking and roasting. Its edible quality, nutritional quality and
Mingjuan LI   +8 more
doaj   +1 more source

Understanding Dietary Protein Quality: Digestible Indispensable Amino Acid Scores and Beyond

open access: yesThe Journal of Nutrition
Dietary protein quality refers to the capacity of a food to meet the human metabolic needs for essential amino acids (EAAs) and nitrogen. This is critical in low- and middle-income countries, where severe protein malnutrition occurs, and relevant in higher-income countries, where increasing dietary EAA intake may improve health and function.
Matthews, Joseph J   +5 more
openaire   +2 more sources

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

Effects of Coix Straw Cultivation Substrate on Amino Acid Composition and Nutritional Value in Grifola frondosa

open access: yesShipin gongye ke-ji
To rationally utilize the resources of Coix straw, this study designed different ratios of Coix straw formulations to cultivate Grifola frondosa, comparatively analyzed the differences among agronomic indices, protein and crude polysaccharide content of ...
Jiajia ZHOU   +6 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

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