Results 61 to 70 of about 4,987,268 (293)

Machine learning-derived AS and AIS scores leverage BCAA metabolism and IL4I1 activity for prognosis and tailored therapy in ccRCC

Frontiers in Cell and Developmental Biology
Background and objectiveRenal cell carcinoma (RCC) is among the most prevalent malignant tumors globally, characterized by a poor prognosis. The 5-year survival rate for advanced clear cell renal cell carcinoma (ccRCC) is below 20%.Materials and ...
Kang Qiang Weng, Xin Li, Xiao bao Chen, Jun wei Lin, Ling jun Liu, Le ye Yan, Ruo yun Xie   +6 more
doaj   +1 more source

Analysis of nutrient composition of Zophobas morio larva meal

Siliao yanjiu, 2023
The experiment was to analysis of nutrient composition of Zophobas morio larva meal. The content and composition of water, ash, crude protein, amino acid, crude fat, fatty acid and mineral elements in Zophobas morio larva meal were determined by national
ZHOU Gen-lai, YIN Jie-xin, ZHANG Hong-yu, BAO Jian-shu   +3 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

AMINO ACID DIGESTIBILITIES OF PALM KERNEL MEAL IN POULTRY [PDF]

, 2008
Palm kernel meal (PKM) is produced in large quantities in many parts of the world. Problems associated with PKM are due to their high fibre content, imbalanced amino acid ratios, the possibility of Maillard products and their own physical ...
Kumar, A, Dingle, J, Sundu, B
core   +1 more source

Amino acid substitution scoring matrices specific to intrinsically disordered regions in proteins [PDF]

Scientific Reports, 2019
AbstractAn amino acid substitution scoring matrix encapsulates the rates at which various amino acid residues in proteins are substituted by other amino acid residues, over time. Database search methods make use of substitution scoring matrices to identify sequences with homologous relationships. However, widely used substitution scoring matrices, such
Trivedi, Rakesh, Nagarajaram, Hampapathalu Adimurthy   +1 more
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Available Amino Acid Score for Evaluating Protein Quality of Foods

Journal of AOAC INTERNATIONAL, 1984
Abstract Amino acid scores corrected for true digestibility of individual amino acids (as determined by rat balance method) were termed “available amino acid scores” in the present investigation. Available amino acid scores were calculated for 7 protein sources and their 10 supplementary or complementary mixtures which have been tested ...
openaire   +2 more sources

Towards more meaningful hierarchical classification of amino acid scoring matrices [PDF]

Protein Engineering, Design and Selection, 1999
Hierarchical classifications of the 20 amino acids according to residue relationships within scoring matrices have not hitherto been tested for reliability. In fact, testing here of the residue groupings obtained thus from 18 published matrices shows that they vary considerably in reliability.
openaire   +2 more sources

PaPI: pseudo amino acid composition to score human protein-coding variants [PDF]

BMC Bioinformatics, 2015
High throughput sequencing technologies are able to identify the whole genomic variation of an individual. Gene-targeted and whole-exome experiments are mainly focused on coding sequence variants related to a single or multiple nucleotides. The analysis of the biological significance of this multitude of genomic variant is challenging and computational
Ivan Limongelli, Simone Marini, Riccardo Bellazzi   +2 more
openaire   +4 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source