Multiple rereads of single proteins at single–amino acid resolution using nanopores
Science, 2021 Description Reading amino acids by nanopore Nanopore technology enables sensing of minute chemical changes at the single-molecule level by detecting differences in an ion current as molecules are drawn through a membrane-embedded pore. The sensitivity is
H. Brinkerhoff +4 more
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An Alternative Model of Amino Acid Replacement [PDF]
, 2004 The observed correlations between pairs of homologous protein sequences are typically explained in terms of a Markovian dynamic of amino acid substitution.
Altschul +27 more
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Characterization of Trypanosoma brucei gambiense variant surface glycoprotein LiTat 1.5 [PDF]
, 2012 At present, all available diagnostic antibody detection tests for Trypanosoma brucei gambiense human African trypanosomiasis are based on predominant variant surface glycoproteins (VSGs), such as VSG LiTat 1.5. During investigations aiming at replacement
Büscher, P. +4 more
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Amino acid metabolism conflicts with protein diversity [PDF]
, 2014 The twenty protein coding amino acids are found in proteomes with different relative abundances. The most abundant amino acid, leucine, is nearly an order of magnitude more prevalent than the least abundant amino acid, cysteine.
Alonso, Leonardo G. +6 more
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Site-Directed Mutagenesis and Site-Specific Binding Analysis of Calmodulin (CaM) [PDF]
, 2017 Calcium signaling is a major regulatory system in cells and a crucial part of cell biology. An important element in the decoding of intracellular calcium concentration into downstream processes is the ubiquitous and highly conserved calcium binding ...
Dokic, Yelena
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The signature motif of the Saccharomyces cerevisiae Pif1 DNA helicase is essential in vivo for mitochondrial and nuclear functions and in vitro for ATPase activity [PDF]
, 2018 Pif1 family DNA helicases are conserved from bacteria to humans and have critical and diverse functions in vivo that promote genome integrity. Pif1 family helicases share a 23 amino acid region, called the Pif1 signature motif (SM) that is unique to this
Galletto, Roberto +3 more
core +2 more sources
OLGA: fast computation of generation probabilities of B- and T-cell receptor amino acid sequences and motifs [PDF]
bioRxiv, 2018 Motivation High-throughput sequencing of large immune repertoires has enabled the development of methods to predict the probability of generation by V(D)J recombination of T- and B-cell receptors of any specific nucleotide sequence.
Zachary M. Sethna +4 more
semanticscholar +1 more source
Aminopeptidase C of Aspergillus niger is a Novel Phenylalanine Aminopeptidase [PDF]
, 2003 A novel enzyme with a specific phenylalanine aminopeptidase activity (ApsC) from Aspergillus niger (CBS 120.49) has been characterized. The derived amino acid sequence is not similar to any previously characterized aminopeptidase sequence but does share ...
Basten, E.J.W. +2 more
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A FAMILY OF CATION ATPASE-LIKE MOLECULES FROM PLASMODIUM-FALCIPARUM [PDF]
, 1993 . We report the nucleotide and derived amino acid sequence of the ATPase 1 gene from Plasmodium falciparum. The amino acid sequence shares homology with the family of "P-type cation transloeating ATPases in conserved regions important for nucleotide
Cowan, G +5 more
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Cloning and characterisation of chlorophyll synthase from Avena sativa [PDF]
, 2001 The chlorophyll synthase gene from oat (Avena sativa) was cloned and expressed in Escherichia coli. The deduced amino acid sequence consists of 378 amino acids including a presequence, of 46 amino acids.
Kögel, Julia +4 more
core +1 more source