Results 51 to 60 of about 2,474,551 (357)
Predicting DNA-binding sites of proteins from amino acid sequence
BMC Bioinformatics, 2006 Background Understanding the molecular details of protein-DNA interactions is critical for deciphering the mechanisms of gene regulation. We present a machine learning approach for the identification of amino acid residues involved in protein-DNA ...
Wu Feihong +5 more
doaj +1 more source
Amino Acid Sequence of Bovine Glucagon
Journal of Biological Chemistry, 1971 Bovine glucagon has been found to have the same amino acid sequence as porcine glucagon. This result is unusual from the standpoint of absolute conservation of primary structure.
W W, Bromer +2 more
openaire +2 more sources
Predicting deleterious amino acid substitutions.
Genome Research, 2001 Many missense substitutions are identified in single nucleotide polymorphism (SNP) data and large-scale random mutagenesis projects. Each amino acid substitution potentially affects protein function. We have constructed a tool that uses sequence homology
P. Ng, S. Henikoff
semanticscholar +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
MOSAL : software tools for multiobjective sequence alignment [PDF]
, 2014 Multiobjective sequence alignment brings the advantage of providing a set of alignments that represent the trade-off between performing insertion/deletions and matching symbols from both sequences. Each of these alignments provide a potential explanation
Monsanto Pinheiro, Miguel +8 more
core +1 more source
Protein sequence alignment with family-specific amino acid similarity matrices
BMC Research Notes, 2011 Background Alignment of amino acid sequences by means of dynamic programming is a cornerstone sequence comparison method. The quality of alignments produced by dynamic programming critically depends on the choice of the alignment scoring function ...
Kuznetsov Igor B
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
The overexpression and characterisation of Enoyl ACP Reductase from Brassica. napus: a component enzyme of fatty acid synthetase in plants [PDF]
, 1995 The main objective of this research is to advance our understanding at the structural and expressional level of plant enoyl ACP reductase (ER), the enzyme which catalyses the last reductive step in the de-novo biosynthesis of fatty acids.
Simon, Josiah William
core
Primary structure and glycosylation of the S-layer protein of Haloferax volcanii
, 1990 The outer surface of the archaebacterium Haloferax volcanii (formerly named Halobacterium volcanii) is covered with a hexagonally packed surface (S) layer. The gene coding for the S-layer protein was cloned and sequenced.
Sumper, Manfred +3 more
core +1 more source
The amino acid sequence of human glucagon [PDF]
FEBS Letters, 1972 The amino acid sequence of bovine glucagon has been found to be the same as that reported for porcine glucagon [ 1,2] . Human glucagon has been isolated and crystallized [3] . The crystal form and the amino acid composition of human glucagon proved to be identical with those of porcine and bovine glucagon.
Thomsen, J. +3 more
openaire +2 more sources