Results 11 to 20 of about 248,141 (296)

The Binding Specificity of Amino Acid Transport System y + L in Human Erythrocytes is Altered by Monovalent Cations [PDF]

Journal of Membrane Biology, 1996
System y+L is a broad-scope amino acid transporter which binds and translocates cationic and neutral amino acids. Na+ replacement with K+ does not affect lysine transport, but markedly decreases the affinity of the transporter for L-leucine and L-glutamine.
Angelo,, Irarrázabal,, Devés, Rosa
semanticscholar   +5 more sources

Nitric Oxide Synthesis Requires Activity of the Cationic and Neutral Amino Acid Transport System y⁺L in Human Umbilical vein Endothelium

Experimental Physiology, 2003
L‐Arginine transport is mediated by the cationic/neutral amino acid transport system y+L and cationic amino acid transporters y+/CATs in human umbilical vein endothelial cells (HUVECs). System y+/CATs activity may be rate‐limiting for nitric oxide (NO) synthesis, but no reports have demonstrated system y+L involvement in NO synthesis in endothelium. We
Arancibia Garavilla, Y, Toledo, F, Casanello, P, Sobrevia, L   +3 more
semanticscholar   +7 more sources

The amino acid transport system y ⁺ L/4F2hc is a heteromultimeric complex

The FASEB Journal, 1998
4F2hc is an almost ubiquitous transmembrane protein in mammalian cells; upon expression in Xenopus laevis oocytes, it induces amino acid transport with characteristics of system y + L.
Estévez, Raúl, Camps, Marta, Rojas, Ana María, Testar, Xavier, Devés, Rosa, Hediger, Matthias A., Zorzano, Antonio, Palacín, Manuel   +7 more
openaire   +3 more sources

Inhibition of endothelial cell amino acid transport System y+ by arginine analogs that inhibit nitric oxide synthase

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1997
A variety of N omega-monosubstituted L-arginine analogs are established inhibitors of nitric oxide synthase; in all cases, initial binding is competitive with the substrate L-arginine. The efficacy of such compounds in vivo will depend on their transport into the relevant nitric oxide synthase-containing cells; in fact, inhibition may actually be ...
McDonald, Kelly K, Rouhani, Riaz, Handlogten, Mary E, Block, Edward R, Griffith, Owen W, Allison, R.Donald, Kilberg, Michael S   +6 more
openaire   +3 more sources

Change in Cationic Amino Acid Transport System and Effect of Lysine Pretreatment on Inflammatory State in Amyotrophic Lateral Sclerosis Cell Model

Biomolecules & Therapeutics, 2021
Amyotrophic lateral sclerosis (ALS) is a lethal neurological disorder characterized by the deterioration of motor neurons. The aim of this study was to investigate alteration of cationic amino acid transporter (CAT-1) activity in the transport of lysine ...
S. Latif, Young-Sook Kang
semanticscholar   +1 more source

Wheat amino acid transporters highly expressed in grain cells regulate amino acid accumulation in grain [PDF]

, 2021
Amino acids are delivered into developing wheat grains to support the accumulation of storage proteins in the starchy endosperm, and transporters play important roles in regulating this process. RNA-seq, RT-qPCR, and promoter-GUS assays showed that three
Zhiqiang Shi, Hawkesford, Malcolm J., Hassall, K. L., Kirsty Hassall, Wan, Y., Wang, Yan, Powers, Stephen, Huttly, Alison K., Buchner, Peter, Caroline A Sparks, Shewry, Peter R., Jane L Ward, Yan Wang, Doris Rentsch, Sparks, Caroline A., Rentsch, Doris, Hassall, Kirsty, Huttly, A. K., Ward, J. L., Peter R Shewry, Alison K Huttly, Malcolm J Hawkesford, Shi, Z., Shi, Zhiqiang, Peter Buchner, Rentsch, D., Stephen Powers, Shewry, P. R., Wan, Yongfang, Yongfang Wan, Powers, S. J., Ward, Jane L., Buchner, P. H., Wang, Y., Sparks, C. A., Hawkesford, M. J.   +35 more
core   +1 more source

The catalytic subunit of the system L1 amino acid transporter (Slc7a5) facilitates nutrient signalling in mouse skeletal muscle [PDF]

, 2014
The System L1-type amino acid transporter mediates transport of large neutral amino acids (LNAA) in many mammalian cell-types. LNAA such as leucine are required for full activation of the mTOR-S6K signalling pathway promoting protein synthesis and cell ...
Adel F M Ibrahim, Yun-Bo Shi, Mitchell, Fiona E., Grant English (527945), Peter M Taylor, Taylor Peter M., Poncet, Nadège, Fiona E Mitchell, Ibrahim Adel F. M., English, Grant, J. Simon C Arthur (527946), Nadège Poncet, Victoria A McGuire, Yun-Bo Shi (193634), Arthur J. Simon C, McGuire Victoria A., Adel F. M. Ibrahim (188343), Grant English, Taylor, Peter M., Ibrahim, Adel F. M., Poncet Nadège, Nadège Poncet (527942), Victoria A. McGuire (527944), Peter M. Taylor (527947), McGuire, Victoria A., English Grant, Arthur, J. Simon C; id_orcid, Mitchell Fiona E., Shi Yun-Bo, Fiona E. Mitchell (527943), Shi, Yun-Bo, J Simon C Arthur   +31 more
core   +1 more source

Root phloem-specific expression of the plasma membrane amino acid proton co-transporter AAP3 [PDF]

, 2004
Amino acids are regarded as the nitrogen ‘currency’ of plants. Amino acids can be taken up from the soil directly or synthesized from inorganic nitrogen, and then circulated in the plant via phloem and xylem.
Sakiko Okumoto, Leister, D., Frommer, Wolf B., Wolf B. Frommer, Okumoto, Sakiko, FISCHER, Wolf N, Stierhof, York Dieter, Frommer, W. B., Stierhof, Y., Stierhof, Y.-D., Fischer, W., Wolfgang Koch, Koch, W., FROMMER, Wolf B, Mechthild Tegeder, Fischer, Wolf N., Leister, Dario, Wolf N. Fischer, Koch, Wolfgang, Okumoto, S., Tegeder, Mechthild, Dario Leister, Tegeder, M., Biehl, A., York Dieter Stierhof, Alexander Biehl, Biehl, Alexander, Fischer, W. N., Frommer, W.   +28 more
core   +1 more source

System y+L: the broad scope and cation modulated amino acid transporter

Experimental Physiology, 1998
The properties are discussed of system y+L, a broad scope amino acid transporter which was first identified in human erythrocytes. System y+L exhibits two distinctive properties: (a) it can bind and translocate cationic and neutral amino acids, and (b) its specificity varies depending on the ionic composition of the medium.
R, Devés, S, Angelo, A M, Rojas
openaire   +2 more sources

Function of SLC7A7 in T-Cell Acute Lymphoblastic Leukemia

Cellular Physiology and Biochemistry, 2018
Background/Aims: Y+LAT1 protein, encoded by the SLC7A7 gene (a member of the SLC7 family), forms the cationic amino acid transport system y+L (system y+L). This system transports cationic amino acids such as arginine and lysine out of the cell. Arginine,
Xiaohui Ji, Xiaoyun Yang, Nan Wang, Meiyun Kang, Yaping Wang, Liucheng Rong, Yongjun Fang, Yao Xue   +7 more
doaj   +1 more source