Results 21 to 30 of about 248,141 (296)

Analysis of LPI-causing mutations on y+LAT1 function and localization

Orphanet Journal of Rare Diseases, 2019
Background y+LAT1, encoded by SCL7A7, is the protein mutated in Lysinuric Protein Intolerance (LPI), a rare metabolic disease caused by a defective cationic amino acid (CAA, arginine, lysine, ornithine) transport at the basolateral membrane of intestinal
Bianca Maria Rotoli, Amelia Barilli, Filippo Ingoglia, Rossana Visigalli, Massimiliano G. Bianchi, Francesca Ferrari, Diego Martinelli, Carlo Dionisi-Vici, Valeria Dall’Asta   +8 more
doaj   +1 more source

Xenogeneic, extracorporeal liver perfusion in primates improves the ratio of branched-chain amino acids to aromatic amino acids (Fischer's ratio) [PDF]

, 1999
In fulminant hepatic failure (FHF), the development of hepatic encephalopathy is associated with grossly abnormal concentrations of plasma amino acids (PAA).
Puhl, G., Neuhaus, P., Schön, M. R., Hammer, C., Matthes, M., Heil, W., Lemmens, H.-P., Padval, D.   +7 more
core   +1 more source

Stimulation of system y(+)-like amino acid transport by the heavy chain of human 4F2 surface antigen in Xenopus laevis oocytes. [PDF]

Proceedings of the National Academy of Sciences, 1992
A kidney cortex cDNA clone (rBAT) has recently been isolated, which upon in vitro transcription and capping complementary RNA (cRNA) and injection into Xenopus laevis oocytes induces a system b0,(+)-like amino acid transport activity. This cDNA encodes a type II membrane glycoprotein that shows significant homology to another type II membrane ...
Bertran, J, Magagnin, S, Werner, A, Markovich, D, Biber, J, Testar, X, Zorzano, A, Kuhn, LC, Palacin, M, Murer, H   +9 more
openaire   +6 more sources

Different types of potassium transport linked to carbachol and γ-aminobutyric acid actions in rat sympathetic neurons [PDF]

, 1984
Carbachol and γ-aminobutyric acid depolarize mammalian sympathetic neurons and increase the free extracellular K+-concentration. We have used double-barrelled ion-sensitive microelectrodes to determine changes of the membrane potential and of the free ...
Ballanyi, Klaus, Ten Bruggencate, Gerrit, Grafe, Peter, Reddy, M. M.   +3 more
core   +1 more source

Uptake of Manganese from the Manganese-Lysine Complex in Primary Chicken Intestinal Epithelial Cells

Animals, 2019
Organic manganese (Mn) sources can replace inorganic Mn as dietary Mn supplements in poultry. To compare the uptake of Mn from the Mn-lysine complex (MnLys) and MnSO4, we first established the primary chicken intestinal epithelial cells (IECs) model and ...
Shiping Bai, Keying Zhang, Xuemei Ding, Jianping Wang, Qiufeng Zeng, Huanwei Peng, Jie Bai, Yue Xuan, Zuowei Su, Bin Wu   +9 more
doaj   +1 more source

Angiotensin II Stimulates System y+ and Cationic Amino Acid Transporter Gene Expression in Cultured Vascular Smooth Muscle Cells [PDF]

Journal of Biological Chemistry, 1995
The effect of angiotensin II (Ang II) on the transport of cationic amino acids has been examined in vascular smooth muscle cells (VSMC) isolated from rat aortae. Ang II stimulated the uptake rates of radiolabeled arginine and lysine in a time- and concentration-dependent manner.
B C, Low, M R, Grigor
openaire   +2 more sources

GSK3-mediated raptor phosphorylation supports amino acid-dependent Q2 mTORC1-directed signalling [PDF]

, 2015
The mammalian or mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a ubiquitously expressed multimeric protein kinase complex that integrates nutrient and growth factor signals for the co-ordinated regulation of cellular metabolism and cell ...
Stretton, Clare, Taylor, Peter M., Hundal, Harinder, Prescott, Alan; id_orcid, Hoffmann, Thorsten M., Ganley, Ian G.; id_orcid, Munson, Michael J.   +6 more
core   +1 more source

Downregulation of SLC7A7 Triggers an Inflammatory Phenotype in Human Macrophages and Airway Epithelial Cells

Frontiers in Immunology, 2018
Lysinuric protein intolerance (LPI) is a recessively inherited aminoaciduria caused by mutations of SLC7A7, the gene encoding y+LAT1 light chain of system y+L for cationic amino acid transport. The pathogenesis of LPI is still unknown.
Bianca Maria Rotoli, Amelia Barilli, Rossana Visigalli, Filippo Ingoglia, Marco Milioli, Maria Di Lascia, Benedetta Riccardi, Paola Puccini, Valeria Dall’Asta   +8 more
doaj   +1 more source

Important differences in cationic amino acid transport by lysosomal system c and system y+ of the human fibroblast.

Journal of Biological Chemistry, 1987
Superficial similarities led us to extend our designation for the transport of the plasma membrane for cationic amino acids, y+, to the lysosomal system also serving for such amino acids. Further study on the purified lysosomes of human skin fibroblasts leads us now to redesignate the lysosomal system as c (for cationic), rather than y+, to emphasize ...
R L, Pisoni, J G, Thoene, R M, Lemons, H N, Christensen   +3 more
openaire   +2 more sources

The binding of auxin to the Arabidopsis auxin influxtransporter, AUX1 [PDF]

, 2008
The cellular import of the hormone auxin is a fundamental requirement for the generation of auxin gradients which control a multitude of plant developmental processes.
Napier, R. (Richard), Callaghan, Richard, Carrier, David J., Swarup, Ranjan, Abu Bakar, Norliza Tendot, Kerr, Ian D., Bennett, Malcolm J., Bakar, Norliza Tendot Abu   +7 more
core   +1 more source