Results 251 to 260 of about 148,306 (298)
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Branched-chain amino acids in disease
Science, 2019Are BCAAs a biomarker, causal agent, or both in cardiometabolic disease?
Phillip J, White, Christopher B, Newgard
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Branched-chain amino acids in cardiovascular disease
Nature Reviews Cardiology, 2022Research conducted in the past 15 years has yielded crucial insights that are reshaping our understanding of the systems physiology of branched-chain amino acid (BCAA) metabolism and the molecular mechanisms underlying the close relationship between BCAA homeostasis and cardiovascular health. The rapidly evolving literature paints a complex picture, in
Robert W. McGarrah, Phillip J. White
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Current Opinion in Clinical Nutrition and Metabolic Care, 2013
There is burgeoning evidence that branch chain amino acids (BCAAs) are biomarkers of metabolic, cardiovascular, renal and cerebrovascular disease. The purpose of this review is to summarize the current evidence in this area.Recent evidence demonstrates that BCAAs are associated with insulin resistance, type 2 diabetes, risk of cardiovascular disease ...
Bryan C, Batch +2 more
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There is burgeoning evidence that branch chain amino acids (BCAAs) are biomarkers of metabolic, cardiovascular, renal and cerebrovascular disease. The purpose of this review is to summarize the current evidence in this area.Recent evidence demonstrates that BCAAs are associated with insulin resistance, type 2 diabetes, risk of cardiovascular disease ...
Bryan C, Batch +2 more
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Hepatology Research, 2004
Significant evidence of the pharmacological and physiological effects of branched-chain amino acids (BCAA) has accumulated, attracting the interest of not only clinicians but also basic medical researchers. We summarize here the characteristic features of BCAA catabolism, focusing on the initial two enzymes in the pathway, branched-chain ...
Yoshiharu, Shimomura +7 more
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Significant evidence of the pharmacological and physiological effects of branched-chain amino acids (BCAA) has accumulated, attracting the interest of not only clinicians but also basic medical researchers. We summarize here the characteristic features of BCAA catabolism, focusing on the initial two enzymes in the pathway, branched-chain ...
Yoshiharu, Shimomura +7 more
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Regulation of Branched-Chain Amino Acid Catabolism ,
The Journal of Nutrition, 1994Catabolism of the branched-chain amino acids is regulated in part at the step catalyzed by the branched-chain alpha-ketoacid dehydrogenase complex. Previous work suggests both short-term and long-term control mechanisms are involved in regulation of the kinase responsible for phosphorylation and inactivation of the branched-chain alpha-ketoacid ...
R A, Harris +3 more
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Branched Chain Amino Acids in Metabolic Disease
Current Diabetes Reports, 2018Elevations in circulating branched chain amino acids (BCAAs) have gained attention as potential contributors to the development of insulin resistance and diabetes.Epidemiological evidence strongly supports this conclusion. Suppression of BCAA catabolism in adipose and hepatic tissues appears to be the primary drivers of plasma BCAA elevations.
Zoltan, Arany, Michael, Neinast
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Branched-Chain Amino Acids and Brain Metabolism
Neurochemical Research, 2017This review aims to provide a historical reference of branched-chain amino acid (BCAA) metabolism and provide a link between peripheral and central nervous system (CNS) metabolism of BCAAs. Leucine, isoleucine, and valine (Leu, Ile, and Val) are unlike most other essential amino acids (AA), being transaminated initially in extrahepatic tissues, and ...
Justin E, Sperringer +2 more
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Transaminase of Branched Chain Amino Acids*
The Journal of Biochemistry, 1968Kenji Aki, Koichi Ogawa, Akira Ichihara
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[The branched-chain amino acids].
Minerva gastroenterologica e dietologica, 2006Branched-chain amino acids (BCAA: leucine, isoleucine and valine) are not just structural constituents of proteins, but have ''pharmacologic'' properties, known for several years: BCAA are catabolized mainly in muscle; can be oxidized with energy production, being nitrogen donors for other amino acids; regulate protein synthesis and degradation ...
C, Chiarla +3 more
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Branched-chain amino acids for hepatic encephalopathy
2003Hepatic encephalopathy may be caused by a decreased plasma ratio of branched-chain amino acids (BCAA) to aromatic amino acids. Treatment with BCAA may therefore have a beneficial effect on patients with hepatic encephalopathy.To evaluate the beneficial and harmful effects of BCAA for patients with hepatic encephalopathy.We identified trials through The
B, Als-Nielsen +3 more
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