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Branched chain amino acids in heptatic encephalopathy
The American Journal of Surgery, 2002Early theories or hepatic encephalopathy focused on ammonia-driven disruption of the Krebs cycle and cellular energy production. The "false-neurotransmitter" theory directed attention toward the interactions of amino acids, metabolism, the blood-brain barrier and neurotransmission.
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Brain metabolism of branched-chain amino acids
Glia, 1997The synthesis of brain glutamate requires an amino group donor that is efficiently transported into the brain and that is readily transaminated. The branched-chain amino acids (BCAA), particularly leucine, play this important role. The uptake of leucine across the blood-brain barrier is faster than any other amino acid.
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[Branched chain amino acid diseases].
Acta medica portuguesa, 1999The authors present 19 cases of branched-chain AA catabolism disease: 9 Maple Syrup Urine Diseases, 6 Methylmalonic Acidemias, 2 Propionic Acidemias, 1 case of 3-OH-3-methylglutaryl-CoA-lyase deficiency and another of 2-methyl-ketoacetyl-CoA-thiolase deficiency. Fifteen are early neonatal forms and in 4 the onset occurred later. Fifteen patients (78.9%)
A, Cabral +5 more
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Amino Acids | Branched-Chain Amino Metabolism
2021Elitsa A. Ananieva, Myra E. Conway
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The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine
Cell Metabolism, 2021Deyang Yu +2 more
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Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer
Cancer Cell, 2020Sharanya Sivanand +1 more
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Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street
Molecular Metabolism, 2021Phillip J. White +2 more
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Branched chain amino acids, aging and age-related health
Ageing Research Reviews, 2020David G Le Couteur, Fracp +2 more
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