Results 51 to 60 of about 7,358,369 (397)

A histidine‐rich extension of the mitochondrial F0 subunit ATP6 from the ice worm Mesenchytraeus solifugus increases ATP synthase activity in bacteria

FEBS Letters, EarlyView.
The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley, Daniel H. Shain, Eric A. Klein   +2 more
wiley   +1 more source

Assessment of bioactive peptides derived from laminin-111 as prospective breast cancer-targeting agents

Amino Acids
Breast cancer remains a pressing public health issue primarily affecting women. Recent research has spotlighted bioactive peptides derived from laminin-111, implicated in breast tumor development.
Fernanda Ferreira Mendonça, Danielle Vieira Sobral, Ana Claudia Ranucci Durante, Ana Cláudia Camargo Miranda, Jorge Mejia, Daniele de Paula Faria, Fabio Luiz Navarro Marques, Marycel Figols de Barboza, Leonardo Lima Fuscaldi, Luciana Malavolta   +9 more
doaj   +1 more source

DPST: De Novo Peptide Sequencing with Amino-Acid-Aware Transformers [PDF]

arXiv, 2022
De novo peptide sequencing aims to recover amino acid sequences of a peptide from tandem mass spectrometry (MS) data. Existing approaches for de novo analysis enumerate MS evidence for all amino acid classes during inference. It leads to over-trimming on receptive fields of MS data and restricts MS evidence associated with following undecoded amino ...
arxiv  

Elucidation of interface interactions between a dehydratase domain and an acyl carrier protein in cremimycin polyketide synthase

FEBS Letters, EarlyView.
In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri, Haruka Tachibana, Daisuke Kawasaki, Taichi Chisuga, Toma Kashima, Shinya Fushinobu, Fumitaka Kudo, Tadashi Eguchi, Akimasa Miyanaga   +8 more
wiley   +1 more source

Variants of the industrially relevant protease KP-43 with suppressed activity under alkaline conditions developed using expanded genetic codes

Biochemistry and Biophysics Reports, 2019
In the present study, we attempted to control the pH profile of the catalytic activity of the industrially relevant alkaline protease KP-43, by incorporating 3-nitro-l-tyrosine and 3-chloro-l-tyrosine at and near the catalytic site. Thirty KP-43 variants
Tatsuya Osamura, Mitsuyoshi Okuda, Atsushi Yamaguchi, Kazumasa Ohtake, Kensaku Sakamoto, Yasushi Takimura   +5 more
doaj  

LLM4THP: a computing tool to identify tumor homing peptides by molecular and sequence representation of large language model based on two-layer ensemble model strategy

Amino Acids
Tumor homing peptides (THPs) have a distinctive capacity to specifically attach to tumor cells, providing a promising approach for targeted cancer treatment and detection.
Sen Yang, Piao Xu
doaj   +1 more source

Pancreatic hormones and amino acid levels following liver transplantation [PDF]

, 1987
Glucose intolerance, hyperinsulinemia, peripheral insulin resistance and hyperglucagonemia are common in patients with advanced liver disease. These abnormalities in the plasma levels of the pancreatic hormones, insulin and glucagon have been thought to ...
Chisholm, Collins, Collins, Conn, Creutzfeldt, Dudley, Eriksson, Fath, Fischer, Hahn, Hamish, Johnston, Kam, Kenny, Limberg, Marchesini, Marchesini, Marchesini, Marchesini, Megysi, Morgan, Muller, Nielsen, Pearly, Reilly, Robertson, Schander, Sherwin, Sherwin, Soeters, Starzl, Starzl, Trinder   +32 more
core   +1 more source

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

FEBS Letters, EarlyView.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten, Lorenz Schwaiger, Zarah Forsberg, Kelsi R. Hall, Anton A. Stepnov, Tom Z. Emrich‐Mills, Iván Ayuso‐Fernández, Morten Sørlie, Roland Ludwig, Åsmund Kjendseth Røhr, Vincent G. H. Eijsink   +10 more
wiley   +1 more source

Combined assessment of lysine and N-acetyl cadaverine levels assist as a potential biomarker of the smoker periodontitis

Amino Acids
Periodontitis is an inflammatory condition of supporting structures of teeth leading to attachment and bone loss. Cigarette smoking is the single most important and modifiable risk factor with 5 to 20-fold susceptibility for periodontal diseases. Reverse
Md Haroon Rashid, Sandhya Pavan Kumar Yellarthi, Pavan Kumar Yellarthi, Brinda Goda Lakshmi Didugu, Anitha Mamillapalli   +4 more
doaj   +1 more source

Sites That Can Produce Left-Handed Amino Acids in the Supernova Neutrino Amino Acid Processing Model [PDF]

, 2018
The Supernova Neutrino Amino Acid Processing model, which uses electron anti-neutrinos and the magnetic field from a source object such as a supernova to selectively destroy one amino acid chirality, is studied for possible sites that would produce meteoroids having partially left-handed amino acids.
arxiv   +1 more source