Results 51 to 60 of about 2,349,548 (333)

Incorporation in vitro of labeled amino acids into bone marrow cell proteins [PDF]

, 1950
Nearly all experiments on the incorporation of labeled amino acids into tissue proteins in vitro have been done on tissues whose cell structure has been partially or completely disintegrated, e.g. tissue slices, segments, or homogenates.
Borsook, Henry, Deasy, Clara L., Haagen-Smit, A. J., Keighley, Geoffrey, Lowy, Peter H.   +4 more
core  

Branched-chain amino acids: physico-chemical properties, industrial synthesis and role in signaling, metabolism and energy production

Amino Acids
Branched-chain amino acids (BCAAs)—leucine (Leu), isoleucine (Ile), and valine (Val)—are essential nutrients with significant roles in protein synthesis, metabolic regulation, and energy production.
Philipp Reifenberg, Aline Zimmer
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Amino acids induce peptide uptake via accelerated degradation of CUP9, the transcriptional repressor of the PTR2 peptide transporter [PDF]

, 2008
Multiple pathways link expression of PTR2, the transporter of di- and tripeptides in the yeast Saccharomyces cerevisiae, to the availability and quality of nitrogen sources.
Abdel-Sater, Abdel-Sater, Alagramam, Andréasson, Andréasson, Bachmair, Bernard, Boban, Boles, Byrd, Cai, Cai, Ditzel, Du, Fosberg, Frommer, Ghislain, Godard, Graciet, Holsbeeks, Homann, Hou, Hu, Hu, Hu, Inobe, Island, Johnson, Jorgensen, Klasson, Kwon, Kwon, Laney, Lee, Liu, Malavé, Mogk, Nielsen, Rao, Roosen, Sasaki, Schneider, Sikorski, Spielewoy, Suzuki, Tasaki, Tasaki, Tasaki, Turner, Turner, Varshavsky, Varshavsky, Varshavsky, Wiles, Wu, Xia, Xiao, Xie, Zenker   +58 more
core   +3 more sources

Combined assessment of lysine and N-acetyl cadaverine levels assist as a potential biomarker of the smoker periodontitis

Amino Acids
Periodontitis is an inflammatory condition of supporting structures of teeth leading to attachment and bone loss. Cigarette smoking is the single most important and modifiable risk factor with 5 to 20-fold susceptibility for periodontal diseases. Reverse
Md Haroon Rashid, Sandhya Pavan Kumar Yellarthi, Pavan Kumar Yellarthi, Brinda Goda Lakshmi Didugu, Anitha Mamillapalli   +4 more
doaj   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Structural insights into the potential binding sites of Cathepsin D using molecular modelling techniques

Amino Acids
Alzheimer’s disease (AD) is the most prevalent type of dementia caused by the accumulation of amyloid beta (Aβ) peptides. The extracellular deposition of Aβ peptides in human AD brain causes neuronal death.
Subodh A. Kamble, Sagar S. Barale, Ali Abdulmawjood Mohammed, Sneha B. Paymal, Nitin M. Naik, Kailas D. Sonawane   +5 more
doaj   +1 more source

Amino Acids, Amino Acid Derivatives and Peptides as Antioxidants

, 2022
[Excerpt] The biological concept of antioxidant refers to any compound that is able to delay or 5 prevent the oxidation of easily oxidizable substrates, such as DNA, proteins and 6 lipids. Antioxidants reduce oxidative stress and mutations in DNA as well as other 7 parameters associated with cell damage.
Monteiro, Luís S., Paiva-Martins, Fátima   +1 more
openaire   +2 more sources

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

HECTD2 as a target for veratric acid in the regulation of ferroptosis in renal cell carcinoma

Amino Acids
Function of HECTD2 in renal cell carcinoma malignant progression is undefined. Molecular mechanism behind anti-cancer effects of veratric acid (VA) from traditional Chinese medicine (TCM) is underexplored.
Dong Lv, Ying Xiang, Tao Song, Jinze Li, Yongbo Chen, Youlong Huili, Taimin Shen   +6 more
doaj   +1 more source