Results 21 to 30 of about 1,865 (171)

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Low Oxygen Availability Increases Itaconate Production by Ustilago maydis

Biotechnology and Bioengineering, Volume 122, Issue 11, Page 3007-3017, November 2025.
ABSTRACT Itaconic acid is a monomer for high performance polymers. While produced in industry with the filamentous fungi Aspergillus terreus, the production with the smut fungus Ustilago maydis was proposed recently. The strict aerobic process suffers from high power input via gassing and stirring. Here, we investigated in detail possible scenarios for
Marianne Volkmar, Wolfgang Laudensack, Felix Bartzack, Niklas Erdmann, Sonja Schönrock, Emely Fuderer, Dirk Holtmann, Lars M. Blank, Roland Ulber   +8 more
wiley   +1 more source

The Effect of Exogenously Applied Dicarboxylic Acids (Photon) on the Maize (Zea mays) Metabolite Profile

Chemistry &Biodiversity, Volume 22, Issue 11, November 2025.
ABSTRACT Maize is an important crop worldwide with approximately 1200 million tons consumed and a market size worth $143 billion. Environmental stress influence production of crops and mitigating these ensures optimum production. Dicarboxylic acids are known as emulsifying agents that mitigate various stresses in plants.
Mhlonipheni Msomi, Noluyolo Nogemane, Garland More, Gerhard Prinsloo   +3 more
wiley   +1 more source

The Role of Metabolites in CSF on NAFLD Development: A Mendelian Randomisation Analysis

Endocrinology, Diabetes &Metabolism, Volume 8, Issue 6, November 2025.
This MR analysis reveals 24 CSF metabolites, notably 7‐HOCA (positively correlated) and uracil (negatively correlated), as causal factors in NAFLD pathogenesis. These findings implicate CNS derived metabolic regulation in hepatic steatosis, proposing novel diagnostic biomarkers and therapeutic targets.
Fang Liang, Tiegang Xiao, Bing Wang
wiley   +1 more source

A Combined Therapy of Brassica Rapa L. Polysaccharides and Dexamethasone in Regulation of Rheumatoid Arthritis and Gut Microbiome

Food Frontiers, Volume 6, Issue 6, Page 3024-3041, November 2025.
This study explored a combined therapy of Brassica rapa L. polysaccharides and dexamethasone with an improved anti‐rheumatic and immunomodulatory effects, which also altered gut microbiome and gut barrier disruption in regulation of rheumatoid arthritis.
Hongkang Zhu, He Qian, Zhenquan Yang, Yu Liu   +3 more
wiley   +1 more source

Contrasting Effects of Probiotic Yogurt and Brown Yogurt on the Urinary Metabolites and Gut Microbial Function of Healthy Adults

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
We identified differing metabolic responses to different types of yogurt. Brown yogurt mainly modulated pathways associated with human and gut microbial ammonia metabolism, whereas probiotic yogurt mainly affected amino acid metabolism. ABSTRACT Consuming yogurt is beneficial for healthy people, but few studies have evaluated the interactions among ...
Si Ting Chen, Tie Min Jiang, Yu Chun Wang, Xia Qi Xiong, Jun Ying Zhao, Li Jun Chen   +5 more
wiley   +1 more source

Identification of MscS as a Key L‐Glutamate Exporter in Bacillus methanolicus

Microbial Biotechnology, Volume 18, Issue 10, October 2025.
l‐Glutamate export in the methylotrophic bacterium Bacillus methanolicus, driven by an MscS‐like mechanosensitive channel. Figure created with BioRender (https://BioRender.com/t99s28). ABSTRACT Small‐conductance mechanosensitive channels (MscS) are established l‐glutamate exporters in industrially relevant bacteria, yet their role in the methylotrophic
Luciana Fernandes Brito, Davide Luciano, Marta Irla, David Virant, Gaston Courtade, Trygve Brautaset   +5 more
wiley   +1 more source

Case Report: Unusual Neurological Features of Leigh Syndrome due to m.8993T>G Pathogenic Variant in the MT‐ATP6 Gene

American Journal of Medical Genetics Part A, Volume 197, Issue 9, September 2025.
ABSTRACT The MT‐ATP6 gene m.8993T>G pathogenic variant has been associated with Leigh syndrome, especially in patients exhibiting a high degree of heteroplasmy. Although patients may present with a wide phenotypic spectrum, characteristic findings include bilateral, symmetric hyperintensities in the basal ganglia and brainstem on brain MRI ...
Ramya Treitel, Julie McLaughlin, Marta Frigeni   +2 more
wiley   +1 more source

Structure, biogenese et roles fonctionnels des poly alpha-aminobutyrates elabores sous controle bacterien dans les nodosites de Medicago sativa L

, 1985
SIGLECNRS T 57979 / INIST-CNRS - Institut de l'Information Scientifique et ...
Gerant Sauvage, D.
core  

Enhanced production of gamma-aminobutyrate (GABA) in recombinant Corynebacterium glutamicum by expressing glutamate decarboxylase active in expanded pH range [PDF]

, 2015
Jae Woong Choi, Sung Sun Yim, Seung Hwan Lee, Taek Jin Kang, Si Jae Park, Ki Jun Jeong   +5 more
openalex   +1 more source