Results 1 to 10 of about 93,718 (253)

Aminoglycosides-Related Ototoxicity: Mechanisms, Risk Factors, and Prevention in Pediatric Patients

Pharmaceuticals, 2023
Aminoglycosides are broad-spectrum antibiotics largely used in children, but they have potential toxic side effects, including ototoxicity. Ototoxicity from aminoglycosides is permanent and is a consequence of its action on the inner ear cells via ...
Serena Rivetti, Alberto Romano, Stefano Mastrangelo, Giorgio Attinà, Palma Maurizi, Antonio Ruggiero   +5 more
doaj   +2 more sources

Aminoglycosides: Nephrotoxicity [PDF]

Antimicrobial Agents and Chemotherapy, 1999
M. Mingeot-Leclercq, P. Tulkens
semanticscholar   +4 more sources

Experimental and Clinical Approaches to Preventing Aminoglycoside-Induced Ototoxicity: A Scoping Review [PDF]

Antioxidants
(1) Aminoglycosides remain indispensable in modern medicine but share a serious dose-limiting adverse effect: irreversible cochleovestibular ototoxicity. (2) This scoping review systematically maps experimental and clinical strategies aimed at preventing
Marek Zadrożniak, Maciej Biskupski, Marcin Szymański, Jarogniew J. Łuszczki   +3 more
doaj   +2 more sources

Aminoglycosides for the Treatment of Severe Infection Due to Resistant Gram-Negative Pathogens

Antibiotics, 2023
Aminoglycosides are a family of rapidly bactericidal antibiotics that often remain active against resistant Gram-negative bacterial infections. Over the past decade, their use in critically ill patients has been refined; however, due to their renal and ...
Michael Thy, J. Timsit, É. de Montmollin   +2 more
semanticscholar   +1 more source

Heat shock potentiates aminoglycosides against gram-negative bacteria by enhancing antibiotic uptake, protein aggregation, and ROS

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Bacterial antibiotic resistance has become a severe threat to human and animal health. Increasing the efficacy of existing antibiotics is a promising strategy against antibiotic resistance. Here, we report that thermal treatment dramatically
Boyan Lv, Xuebing Huang, Chenchen Lijia, Yuelong Ma, Mengmeng Bian, Zhongyan Li, J. Duan, Fang Zhou, Bin Yang, Xingwang Qie, Yizhi Song, T. Wood, Xinmiao Fu   +12 more
semanticscholar   +1 more source

Evaluating the efficacy of inhaled amikacin as an adjunct to intravenous combination therapy (ceftazidime and amikacin) in pediatric cystic fibrosis pulmonary exacerbation

Frontiers in Pharmacology, 2023
Background:Pseudomonas aeruginosa is the most common microorganism found in the sputum culture of Cystic fibrosis (CF) patients causing the pulmonary destruction.
Amin Rakhshan, Nazanin Farahbakhsh, Ghamartaj Khanbabaee, Seyed Ahmad Tabatabaii, Saeed Sadr, Maryam Hassanzad, Mohammad Sistanizad, Farzaneh Dastan, Mahmoud Hajipour, Amir Reza Bahadori, Bahador Mirrahimi   +10 more
doaj   +1 more source

Clinical Pharmacogenetics Implementation Consortium Guideline for the Use of Aminoglycosides Based on MT‐RNR1 Genotype

Clinical pharmacology and therapy, 2021
Aminoglycosides are widely used antibiotics with notable side effects, such as nephrotoxicity, vestibulotoxicity, and sensorineural hearing loss (cochleotoxicity).
J. McDermott, J. Wolf, Keito Hoshitsuki, Rachel Huddart, K. Caudle, Michelle Whirl‐Carrillo, P. Steyger, Richard J. H. Smith, Neal A. L. Cody, C. Rodríguez‐Antona, T. Klein, W. Newman   +11 more
semanticscholar   +1 more source

Acute mixed vestibulopathy. History case from the vestibulologist practice. Case report

Consilium Medicum, 2023
Patients with acute vestibulopathy are among the most uneasy (in terms of severity of symptoms) and challenging (in terms of determining the level of damage).
Sergei V. Lilenko, Dmitry S. Luppov
doaj   +1 more source

Mechanism and Prevention of Ototoxicity Induced by Aminoglycosides

Frontiers in Cellular Neuroscience, 2021
Aminoglycosides, a class of clinically important drugs, are widely used worldwide against gram-negative bacterial infections. However, there is growing evidence that aminoglycosides can cause hearing loss or balance problems.
Xiaolong Fu, Peifeng Wan, Peipei Li, Jinpeng Wang, Siwei Guo, Yuan Zhang, Yachun An, Chao Ye, Ziyi Liu, Jiangang Gao, Jianming Yang, Jiangang Fan, R. Chai   +12 more
semanticscholar   +1 more source

Development of a Fluorescence Polarization Assay for Multi-Determination of 10 Aminoglycosides in Pork Muscle Sample Based on Ribosomal Protein S12 and Studying Its Recognition Mechanism

Foods, 2022
The residues of aminoglycosides in foods of animal origin are a potential risk to consumers. There have been some immunoassays reported for the screening of aminoglycoside residues, but the method showing the broadest detection spectrum can only be used ...
Wanqiu Xia, Lei Zhang, Jianping Wang
doaj   +1 more source