Results 11 to 20 of about 93,718 (253)

Genomics of Aminoglycoside Resistance in Pseudomonas aeruginosa Bloodstream Infections at a United States Academic Hospital

Microbiology Spectrum, 2023
Pseudomonas aeruginosa frequently becomes resistant to aminoglycosides by the acquisition of aminoglycoside modifying enzyme (AME) genes and the occurrence of mutations in the mexZ, fusA1, parRS, and armZ genes.
Giancarlo Atassi, Rachel Medernach, Marc Scheetz, Sophia Nozick, Nathaniel J. Rhodes, Megan Murphy-Belcaster, Katherine R. Murphy, Arghavan Alisoltani, Egon A. Ozer, Alan R. Hauser   +9 more
doaj   +1 more source

Risk of Acute Kidney Injury with Amikacin versus Gentamycin both in Combination with Metronidazole for Surgical Prophylaxis [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Surgical site infection is one of the most important complication of surgery. It increases the mortality and morbidity. In order to decrease the incidence of surgical site infections perioperative antimicrobial prophylaxis has been ...
Vishal Prakash Giri, Om Prakash Giri, Subarna Bajracharya, Farhan Ahmad Khan, Shanker Prasad Sinha, Shubhra Kanodia, Chitrak Bansal   +6 more
doaj   +1 more source

Membrane voltage dysregulation driven by metabolic dysfunction underlies bactericidal activity of aminoglycosides

bioRxiv, 2020
Aminoglycosides are broad-spectrum antibiotics whose mechanism of bactericidal activity has been under debate. It is widely accepted, however, that membrane voltage potentiates aminoglycoside activity, which is ascribed to voltage dependent drug uptake ...
Giancarlo N. Bruni, Joel M. Kralj
semanticscholar   +1 more source

Aminoglycosides for infective endocarditis: time to say goodbye?

Clinical Microbiology and Infection, 2020
BACKGROUND Based on experimental studies showing synergism with β-lactams and glycopeptides, aminoglycosides have long been considered essential in the treatment of infective endocarditis (IE).
D. Lebeaux, N. Fernández-hidalgo, B. Pilmis, P. Tattevin, J. Mainardi   +4 more
semanticscholar   +1 more source

Sensitization of Gram-Negative Bacteria to Aminoglycosides with 2-Aminoimidazole Adjuvants

Antibiotics, 2023
In 2019, five million deaths associated with antimicrobial resistance were reported by The Centers for Disease Control and Prevention (CDC). Acinetobacter baumannii, a Gram-negative bacterial pathogen, is among the list of urgent threats.
Ashley N. Crotteau, Veronica B. Hubble, Santiana A. Marrujo, Anne E. Mattingly, Roberta J. Melander, Christian Melander   +5 more
doaj   +1 more source

Urinary tract infection in critically ill patients with diabetes mellitus: Spectrum of uropathogens and antimicrobial susceptibility pattern

Bali Journal of Anesthesiology, 2020
Background: Urinary tract infections (UTIs) are common and more severe among patients with diabetes mellitus (DM). UTI in DM is more likely to be caused by bacteria resistant to various antimicrobials.
Nand Kishore, Sagar Modi, Sushant Khanduri, Barnali Kakati   +3 more
doaj   +1 more source

Machine Learning Establishes Single-Cell Calcium Dynamics as an Early Indicator of Antibiotic Response

Microorganisms, 2021
Changes in bacterial physiology necessarily precede cell death in response to antibiotics. Herein we investigate the early disruption of Ca2+ homeostasis as a marker for antibiotic response.
Christian T. Meyer, Megan P. Jewell, Eugene J. Miller, Joel M. Kralj   +3 more
doaj   +1 more source

Molecular mechanisms of antibiotic co-resistance among carbapenem resistant Acinetobacter baumannii

Journal of Infection in Developing Countries, 2019
Introduction: The spread of carbapenem-resistant Acinetobacter baumannii (CRAB) is difficult to control especially in the hospitals due to the successful mobilization and evolution of the genetic elements harboring the resistant determinants.
Mohsin Khurshid, Muhammad Hidayat Rasool, Muhammad Hussnain Siddique, Farrukh Azeem, Muhammad Naeem, Muhammad Sohail, Muhammad Sarfraz, Muhammad Saqalein, Zeeshan Taj, Muhammad Atif Nisar, Muhammad Usman Qamar, Asim Shahzad   +11 more
doaj   +1 more source

Aminoglycoside Antibiotics Inhibit Phage Infection by Blocking an Early Step of the Infection Cycle

mBio, 2022
In response to viral predation, bacteria have evolved a wide range of defense mechanisms, which rely mostly on proteins acting at the cellular level.
Larissa Kever, Aël Hardy, Tom Luthe, Max Hünnefeld, Cornelia Gätgens, Lars Milke, Johanna Wiechert, Johannes Wittmann, Cristina Moraru, Jan Marienhagen, Julia Frunzke   +10 more
doaj   +1 more source

Electrolyte and Acid-Base Disorders Triggered by Aminoglycoside or Colistin Therapy: A Systematic Review

Antibiotics, 2021
Aminoglycoside or colistin therapy may alter the renal tubular function without decreasing the glomerular filtration rate. This association has never been extensively investigated.
Martin Scoglio, Gabriel Bronz, Pietro O. Rinoldi, Pietro B. Faré, Céline Betti, Mario G. Bianchetti, Giacomo D. Simonetti, Viola Gennaro, Samuele Renzi, Sebastiano A. G. Lava, Gregorio P. Milani   +10 more
doaj   +1 more source