Results 31 to 40 of about 93,718 (253)

KI04 an Aminoglycosides-Derived Molecule Acts as an Inhibitor of Human Connexin46 Hemichannels Expressed in HeLa Cells

Biomolecules, 2023
Background: Connexins (Cxs) are proteins that help cells to communicate with the extracellular media and with the cytoplasm of neighboring cells. Despite their importance in several human physiological and pathological conditions, their pharmacology is ...
Cheng-Wei T. Chang, Naveena Poudyal, Daniel A. Verdugo, Francisca Peña, Jimmy Stehberg, Mauricio A. Retamal   +5 more
doaj   +1 more source

Influência dos polimorfismos da glutationa s-transferase na ototoxicidade dos aminoglicosídeos Influence of glutathione s-transferase on the ototoxicity caused by aminoglycosides

Brazilian Journal of Otorhinolaryngology, 2010
O processo de morte e danos em células ciliadas devido à exposição ao ruído e ototoxinas parece ser mediado por espécies reativas de oxigênio. OBJETIVO: Investigar a relação entre polimorfismos gênicos na Glutationa S-transferase e a susceptibilidade à ...
Bruna Palodetto, Mariana Postal, Carlos Roberto Escrivão Grignoli, Edi Lúcia Sartorato, Camila Andréa de Oliveira   +4 more
doaj   +1 more source

Transcriptome profiling in response to Kanamycin B reveals its wider non-antibiotic cellular function in Escherichia coli

Frontiers in Microbiology, 2022
Aminoglycosides are not only antibiotics but also have wider and diverse non-antibiotic cellular functions. To elucidate the understanding of non-antibiotic cellular functions, here we report transcriptome-profiling analysis of Escherichia coli in the ...
Yaowen Chang, Xuhui Zhang, Alastair I. H. Murchie, Dongrong Chen   +3 more
doaj   +1 more source

The Impact of an Efflux Pump Inhibitor on the Activity of Free and Liposomal Antibiotics against Pseudomonas aeruginosa

Pharmaceutics, 2021
The eradication of Pseudomonas aeruginosa in cystic fibrosis patients has become continuously difficult due to its increased resistance to treatments.
Douweh Leyla Gbian, Abdelwahab Omri
doaj   +1 more source

Metabolite-Enabled Eradication of Bacterial Persisters by Aminoglycosides

Nature, 2011
Bacterial persistence is a state in which a sub-population of dormant cells, or ‘persisters’, tolerates antibiotic treatment. Bacterial persisters have been implicated in biofilms and in chronic and recurrent infections.
K. Allison, M. P. Brynildsen, J. Collins
semanticscholar   +1 more source

Positive Bacterial Culture among Adults with Suspected Urinary Tract Infections Presenting to the Department of Medicine of a Tertiary Care Centre

Journal of Nepal Medical Association
Introduction: Urinary tract infections are the most common infections encountered in clinical practice. Treatment needs to take into account the likely organism, comorbidities and local antibiotic sensitivity pattern.
Bishnu Jwarchan, Subash Sapkota, Durga Dhungana, Anil Dhakal   +3 more
doaj   +1 more source

Synthesis of 6″-Modified Kanamycin A Derivatives and Evaluation of Their Antibacterial Properties

Pharmaceutics, 2023
Aminoglycosides are one of the first classes of antibiotics to have been used clinically, and they are still being used today. They have a broad spectrum of antimicrobial activity, making them effective against many different types of bacteria.
Kseniya Shapovalova, Georgy Zatonsky, Natalia Grammatikova, Ilya Osterman, Elizaveta Razumova, Andrey Shchekotikhin, Anna Tevyashova   +6 more
doaj   +1 more source

Novel small molecules potentiate premature termination codon readthrough by aminoglycosides

Nucleic Acids Research, 2016
Nonsense mutations introduce premature termination codons and underlie 11% of genetic disease cases. High concentrations of aminoglycosides can restore gene function by eliciting premature termination codon readthrough but with low efficiency.
Alireza Baradaran-Heravi, A. Balgi, Carla Zimmerman, Kunho Choi, Fahimeh S. Shidmoossavee, J. Tan, Célia Bergeaud, Alexandra L Krause, S. Flibotte, Y. Shimizu, H. Anderson, V. Mouly, E. Jan, T. Pfeifer, James B. Jaquith, M. Roberge   +15 more
semanticscholar   +1 more source