Results 61 to 70 of about 93,718 (253)

Aminoglycoside-Induced Cochleotoxicity: A Review

Frontiers in Cellular Neuroscience, 2017
Aminoglycoside antibiotics are used as prophylaxis, or urgent treatment, for many life-threatening bacterial infections, including tuberculosis, sepsis, respiratory infections in cystic fibrosis, complex urinary tract infections and endocarditis ...
Meiyan Jiang, Takatoshi Karasawa, Peter S. Steyger, Peter S. Steyger   +3 more
doaj   +1 more source

Resistome flow in global landfill systems

iMetaOmics, EarlyView.
Global landfill systems represent key hubs of resistome, serving as dynamic reservoirs and amplifiers through plasmid‐driven gene mobility. Waste flows and environmental pathways sustain the transboundary resistome networks, accelerating resistance dissemination across ecosystems.
Wenqing Hong, Rui Zhang, Xiaoxing Lin, Yangqing Wang, Shu Yang, Farees ud din Mufti, Yuping Yao, Guowei Zhou, Chuanwu Xi, Weixi Shu, Gordon Price, Youcai Zhao, Liyan Song   +12 more
wiley   +1 more source

Synergistic Effect and Mechanism of Plumbagin with Gentamicin Against Carbapenem-Resistant Klebsiella pneumoniae

Infection and Drug Resistance, 2020
Xiuli Chen,* Liyuan Yin,* Linxiu Peng, Yanshan Liang, Hang Lv, Tonghui Ma School of Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, People’s Republic of China*These authors contributed equally to this ...
Chen X, Yin L, Peng L, Liang Y, Lv H, Ma T   +5 more
doaj  

Aminoglycosides restore full-length type VII collagen by overcoming premature termination codons: therapeutic implications for dystrophic epidermolysis bullosa.

Molecular Therapy, 2014
Patients with recessive dystrophic epidermolysis bullosa (RDEB) have severe, incurable skin fragility, blistering, and multiple skin wounds due to mutations in the gene encoding type VII collagen (C7), the major component of anchoring fibrils mediating ...
J. Cogan, J. Weinstein, Xinyi Wang, Yingping Hou, Sabrina Martin, A. South, D. Woodley, Mei Chen   +7 more
semanticscholar   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, EarlyView.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Cyclic Peptide MV6, an Aminoglycoside Efficacy Enhancer Against Acinetobacter baumannii

Antibiotics
Background/Objectives: Acinetobacter baumannii is a globally emerging pathogen with widespread antimicrobial resistance driven by multiple mechanisms, such as altered expression of efflux pumps like AdeABC, placing it as a priority for research.
Natalia Roson-Calero, Jimmy Lucas, María A. Gomis-Font, Roger de Pedro-Jové, Antonio Oliver, Clara Ballesté-Delpierre, Jordi Vila   +6 more
doaj   +1 more source

Polydopamine‐Antibiotic Composite Coating for Antibiofilm Applications

Macromolecular Bioscience, EarlyView.
Antibiotic‐loaded polydopamine coatings are developed to combat biofilm‐forming bacteria on catheter surfaces. These coatings strongly inhibit Pseudomonas aeruginosa biofilm formation on diverse materials, including during continuous artificial‐urine flow, and can accommodate multiple antibiotics.
Gillian A. Kropp, Hannah Q. Karp, Jayasimha Rao, Henriette Suzanne Muller, Nammalwar Sriranganathan, Elizabeth S. Nowak, Michael D. Schulz   +6 more
wiley   +1 more source

Aminoglycoside heteroresistance in Enterobacter cloacae is driven by the cell envelope stress response

mBio
Enterobacter cloacae is a Gram-negative nosocomial pathogen of the ESKAPE (Enterococcus, Staphylococcus, Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter spp.) priority group with increasing multi-drug resistance via the acquisition of resistance
Ana J. Choi, Daniel J. Bennison, Esha Kulkarni, Hibah Azar, Haoyu Sun, Hanqi Li, Jonathan Bradshaw, Hui Wen Yeap, Nicholas Lim, Vishwas Mishra, Anna Crespo-Puig, Ewurabena A. Mills, Frances Davies, Shiranee Sriskandan, Avinash R. Shenoy   +14 more
doaj   +1 more source

Glyco‐Nanogels for Modulating Pseudomonas aeruginosa Biofilm

Macromolecular Rapid Communications, EarlyView.
Nanogels presenting α‐galactose and β‐fucose can significantly alter Pseudomonas aeruginosa biofilm dynamics through their interaction with lectins. Application timing is crucial: pre‐treatment reduces biofilm, while treatment after biofilm initiation increases biomass.
Sophia Rosencrantz, Jo Sing Julia Tang, Karina Koenig, Sany Chea, Ruben R. Rosencrantz   +4 more
wiley   +1 more source

H-NS controls the susceptibility of Escherichia coli to aminoglycosides by interfering its uptake and efflux

Frontiers in Veterinary Science
H-NS is a histone-like nucleoid-structuring protein that regulates gene expressions, particularly acquired foreign genes, however, little is known about whether H-NS can modulate bacterial susceptibility by regulating its intrinsic genes. The hns-deleted
Qiuru Chen, Yulei Liang, Yanbin Dong, Junling Cui, Kun He, Xiaoyuan Ma, Jinfeng Zhao, Jinfeng Zhao, Yajun Zhai, Yajun Zhai, Li Yuan, Li Yuan, Li Yuan, Li Yuan   +13 more
doaj   +1 more source