Results 61 to 70 of about 5,910,522 (194)

Immunomodulatory effects of photodynamic therapy for skin cancer: Potential strategies to improve treatment efficacy and tolerability

Photochemistry and Photobiology, EarlyView.
Photodynamic therapy (PDT) is a nonscarring treatment modality that is widely used for skin cancers and early squamous precursor lesions. PDT was previously thought to work primarily by killing cancer cells directly (via apoptosis or necrosis). However, more recent work indicates that a significant mechanism for PDT is the stimulation of anti‐cancer ...
Mark P. Ortenzio, Sanjay Anand, Jeffrey B. Travers, Edward V. Maytin, Craig A. Rohan   +4 more
wiley   +1 more source

Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer

Molecules, 2011
Aminolevulinic acid (ALA) is an endogenous metabolite normally formed in the mitochondria from succinyl-CoA and glycine. Conjugation of eight ALA molecules yields protoporphyrin IX (PpIX) and finally leads to formation of heme.
Jakub Golab, Kamil Bojarczuk, Małgorzata Wańczyk, Magdalena Winiarska, Magdalena Gabrysiak, Małgorzata Firczuk, Angelika Muchowicz, Małgorzata Wachowska   +7 more
doaj   +1 more source

Photodynamic priming (PDP) targets platinum resistance from chronic perfluoroalkyl substances (PFAS) exposure in ovarian cancer cells

Photochemistry and Photobiology, EarlyView.
PFAS are environmental contaminants that induce chemoresistance in ovarian cancer cells. This study evaluated BPD‐PDP or ALA‐PpIX‐PDP in combination with carboplatin or doxorubicin to overcome PFAS‐induced chemoresistance in two cell cohorts: (i) PFAS chronically‐exposed and (ii) PFAS outgrown cells (which underwent a “recovery period” after chronic ...
Brittany P. Rickard, Meghan M. Dillon, Lauren A. Sapienza‐Lundie, Suzanne E. Fenton, Imran Rizvi   +4 more
wiley   +1 more source

Treatment of sarcopenia and glucose intolerance through mitochondrial activation by 5-aminolevulinic acid

Scientific Reports, 2017
Recently, sarcopenia has attracted attention as therapeutic target because it constitutes a risk factor for metabolic and cardiovascular diseases.
Chikako Fujii, K. Miyashita, Masanori Mitsuishi, Masaaki Sato, K. Fujii, H. Inoue, Aika Hagiwara, Sho Endo, Asuka Uto, Masaki Ryuzaki, M. Nakajima, Tohru Tanaka, Masanori Tamaki, Ayako Muraki, T. Kawai, H. Itoh   +15 more
semanticscholar   +1 more source

Time‐series multi‐omics analysis of micronutrient stress in Sorghum bicolor reveals iron and zinc crosstalk and regulatory network conservation

Plant Biology, EarlyView.
Overlap between Fe and Zn responsive gene regulatory networks (GRNs) were found, indicative of micronutrient crosstalk, and conservation of root and leaf GRNs and genes suggests strong constraint on homeostasis networks in plants. Abstract Micronutrient stress impacts growth, biomass production, and grain yield in crops.
A. Mishra, A. Bhat, S. Kumari, R. Sharma, J. Braynen, D. Tadesse, S. El Alaoui, S. Seaver, N. Grosjean, D. Ware, M. Xie, T. Paape   +11 more
wiley   +1 more source

Exogenous Glutathione and Nitric Oxide Improve Waterlogging Stress Tolerance in Maize

Plant-Environment Interactions, Volume 7, Issue 2, April 2026.
Exogenous glutathione (GSH) and nitric oxide (NO) enhance waterlogging tolerance in maize seedlings by reducing oxidative damage and improving growth. Combined GSH + NO treatment reduces H2O2 and malondialdehyde levels, enhances antioxidant defenses, protects photosynthetic pigments, and promotes biomass accumulation, thereby improving the ...
Prodipto Bishnu Angon, Md. Tahjib‐Ul‐Arif, Md. Sarwar Jahan, Md. Mahadi Hasan, Yoshiyuki Murata   +4 more
wiley   +1 more source

EFFECT OF IRON NANO CHELATE ON ANTIOXIDANT ACTIVITY, POLYPHENOLIC CONTENTS AND ESSENTIAL OIL COMPOSITION OF PORTULACA OLERACEA L.

Acta Scientiarum Polonorum: Hortorum Cultus, 2018
In the present study, using ultrasonic irradiations, a novel nano-sized iron complex has been prepared from aminolevulinic acid and iron(III) nitrate under greenhouse conditions.
Vahid Tavallali
doaj   +1 more source

Plastid Engineering for Photosynthesis‐Driven Synthesis of Hyaluronic Acid in Tobacco

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2541-2558, April 2026.
ABSTRACT Hyaluronic acid (HA) is a glycosaminoglycan composed of alternating units of N‐acetylglucosamine and glucuronic acid. High moisture retention, viscoelasticity and biocompatibility are unique features that make HA polymers attractive compounds for medical applications and aesthetic purposes.
Amanda Lopes, Omar Sandoval‐Ibáñez, Stéphanie Arrivault, David Rolo, F. Vanessa Loiacono, Alexander Erban, Daniel Karcher, Stephan Obst, Stephanie Ruf, Joachim Kopka, Ralph Bock   +10 more
wiley   +1 more source

The Case of a 37‐Year‐Old Woman Presenting With Subacute Weakness and Paresthesias

Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 639-640, March 2026.
ABSTRACT Acute intermittent porphyria (AIP) is a rare metabolic disorder that may present with subacute neuropathy and systemic symptoms, often leading to diagnostic delay. We report a 37‐year‐old woman with eight weeks of progressive bilateral upper extremity weakness and paresthesias, followed by lower extremity involvement and falls, in the setting ...
Peter Pacut, Joy Cannon, Neel Dixit, Qihua Fan   +3 more
wiley   +1 more source

Enhancement of 5-aminolevulinic acid-induced photodynamic therapy by a bioadhesive polymer

Journal of Dental Sciences, 2010
Using a topical formulation of 5-aminolevulinic acid (ALA), a mediated photodynamic therapy (PDT) was developed to treat oral precancerous and cancerous lesions.
Shu-Fang Chang, Yu-Tsai Yang, Wei-Ling Li, Che-Tong Lin, Tsuimin Tsai   +4 more
doaj   +1 more source