Results 41 to 50 of about 41,379 (247)

Biliary aminopeptidase-N and the cholesterol crystallization defect in cholelithiasis

, 1995
Several biliary proteins have cholesterol crystallisation promoting activity. One of these glycoproteins is aminopeptidase-N, a canalicular ectoenzyme. This study attempted to localise aminopeptidase-N along the biliary tree, to assess its concentration ...
Mingrone, G., Greco, A., Núñez, L., Pimentel González, Eduardo Fernando, Garrido Negri, Jorge, Nervi Oddone, Flavio, Rigotti Rivera, Attilio Gianpietro, Puglielli, L., Amigo Boker, Ludwig Peter, Raddatz Echavarría, Alejandro, González, S., Miquel Poblete, Juan Francisco   +11 more
core   +1 more source

High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma

Molecules, 2020
Proteomic technologies have identified 234 peptidases in plasma but little quantitative information about the proteolytic activity has been uncovered.
Elisa Maffioli, Zhenze Jiang, Simona Nonnis, Armando Negri, Valentina Romeo, Christopher B. Lietz, Vivian Hook, Giuseppe Ristagno, Giuseppe Baselli, Erik B. Kistler, Federico Aletti, Anthony J. O’Donoghue, Gabriella Tedeschi   +12 more
doaj   +1 more source

Purification of Advanced Therapeutics by Flow-Through Pseudo-Affinity Chromatography: Bi-Specific mABs, Fc Fusion Proteins, and Adeno-Associated Viruses. [PDF]

Biotechnol Bioeng
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Chu W, Barbieri E, Minzoni A, Shastry S, LeBarre JP, Shu Q, Williams T, Li X, Chandra D, Xu X, Bill J, Roush D, Taris J, Gilbert P, Kiesewetter A, Rammo O, Schulte M, Major C, Mouchahoir T, Cramer S, Boi C, Carbonell RG, Lenhoff A, Menegatti S.   +23 more
europepmc   +2 more sources

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Altered hippocampal gene expression, glial cell population, and neuronal excitability in aminopeptidase P1 deficiency

Scientific Reports, 2021
Inborn errors of metabolism are often associated with neurodevelopmental disorders and brain injury. A deficiency of aminopeptidase P1, a proline-specific endopeptidase encoded by the Xpnpep1 gene, causes neurological complications in both humans and ...
Sang Ho Yoon, Young-Soo Bae, Sung Pyo Oh, Woo Seok Song, Hanna Chang, Myoung-Hwan Kim   +5 more
doaj   +1 more source

MiniSdd7‐Derived Cytosine Base Editor Promotes Efficient Multiplex Gene Knockout in Porcine Primary Fibroblasts

Animal Research and One Health, EarlyView.
The miniSdd7‐BE4max‐SpG system enables highly efficient multiplex C‐to‐T base editing of APN, CD163, and MSTN in porcine fibroblasts, providing a robust platform for future development of multiplex gene‐edited livestock. ABSTRACT Efficient multiplex genome editing is essential for improving complex traits in livestock that are governed by multiple ...
Shaoshuai Wang, Yu Wang, Dengfeng Bi, Jianguo Zhao, Yanfang Wang   +4 more
wiley   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

A thiol-activated aminopeptidase of the pituitary [PDF]

, 1963
Thiol-activated aminopeptidase of pituitary ...
Ellis, S.
core  

Characterization of the Lactococcus lactis pepN gene encoding an aminopeptidase homologous to mammalian aminopeptidase N [PDF]

, 1992
The nucleotide sequence of the pepN gene from lactococcus lactis encoding a zinc-metallo aminopeptidase has been determined. The open reading frame of 2,538 base pairs encodes a protein with a calculated Mr of 95,368, which agrees with the apparent Mr of
Bert Poolman, Roland J. Siezen, Paris S.T. Tan, W.N. Konings, Willem M. de Vos, Ingrid J. van Alen-Boerrigter, DEVOS, WM, KONINGS, WN, TAN, PST, VANALENBOERRIGTER, IJ, SIEZEN, RJ, POOLMAN, B   +11 more
core   +3 more sources

cDNA Cloning and Expression of Human Glutamyl Aminopeptidase (Aminopeptidase A)

Genomics, 1993
The murine B-lymphocyte differentiation antigen BP-1/6C3 has been identified as glutamyl aminopeptidase (E-AP), formerly known as aminopeptidase A, the new gene symbol for which is ENPEP. In mice, the enzyme is found on early B-lineage cells and certain stromal cells of the bone marrow and thymus.
L, Li, J, Wang, M D, Cooper
openaire   +2 more sources