Results 21 to 30 of about 40,140 (225)
Hypertension, 2008 Several decades of investigation have provided unequivocal support for the existence of an intrinsic brain renin-angiotensin (Ang) system (RAS) and its involvement in the control of cardiovascular functions.1,2 Essential components of the RAS, ie, renin, angiotensinogen, Ang-converting enzyme, Ang-converting enzyme 2, type 1 Ang II, and type 2 Ang II ...
Anderson J. Ferreira, Mohan K. Raizada
openaire +1 more source
Microorganisms, 2022 Pseudomonas aeruginosa is a dominant cause of respiratory infection in individuals with cystic fibrosis (CF), leading to significant morbidity and mortality. Detection of P.
Thang V. Truong +8 more
doaj +1 more source
Cloning and heterologous expression of bovine pyroglutamyl peptidase type-1 in Escherichia coli : purification , biochemical and kinetic characterisation [PDF]
, 2007 We describe the cloning, expression and purification of the bovine XM866409 form of pyroglutamyl-aminopeptidase I. The amino acid sequence, deduced from the nucleotide sequence, revealed that it consists of 209 amino acid residues and showed to have 98 ...
O'Connor, Brendan +5 more
core +2 more sources
Frontiers in Molecular Biosciences, 2020 Placental leucine aminopeptidase/insulin-regulated aminopeptidase (P-LAP/IRAP) regulates vasopressin and oxytocin levels in the brain and peripheral tissues by controlled degradation of these peptides.
Yoshikuni Goto +4 more
doaj +1 more source
Frontiers in Physiology, 2023 Introduction: Ventilator-induced lung injury (VILI) may aggravate critical illness. Although angiotensin-converting enzyme (ACE) inhibition has beneficial effects in ventilator-induced lung injury, its clinical application is impeded by concomitant ...
Xinjun Mao +11 more
doaj +1 more source
Biomedicines, 2018 Functional roles of the angiotensin peptides of the renin-angiotensin system (RAS) cascade can be analyzed through their corresponding proteolytic regulatory enzymes aspartyl aminopeptidase (ASAP), aminopeptidase A (APA), aminopeptidase B (APB ...
María Jesús Ramírez-Expósito +1 more
doaj +1 more source
Frontiers in Immunology, 2017 Streptococcus pneumoniae (Spn) causes a variety of disease states including fatal bacterial pneumonia. Our previous finding that introduction of Spn into an animal with ongoing influenza virus infection resulted in a CD8+ T cell population with reduced ...
Lance K. Blevins +5 more
doaj +1 more source
Metallopeptidases of Toxoplasma gondii: in silico identification and gene expression
Parasite, 2018 Metallopeptidases are a family of proteins with domains that remain highly conserved throughout evolution. These hydrolases require divalent metal cation(s) to activate the water molecule in order to carry out their catalytic action on peptide bonds by ...
Escotte-Binet Sandie +6 more
doaj +1 more source
Pharmaceuticals, 2021 Insulin-Regulated aminopeptidase (IRAP) is a zinc-dependent aminopeptidase with several important biological functions and is an emerging pharmaceutical target for cognitive enhancement and immune system regulation.
Ioannis Temponeras +3 more
doaj +1 more source
IRAP Inhibitors: M1-Aminopeptidase Family Inspiration
Frontiers in Pharmacology, 2020 The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer’s disease and immune disorders.
Nicholas Barlow, Philip E. Thompson
doaj +1 more source