Results 21 to 30 of about 29,120 (189)

Proteases as Therapeutic Targets Against the Parasitic Cnidarian Ceratonova shasta: Characterization of Molecules Key to Parasite Virulence In Salmonid Hosts

Frontiers in Cellular and Infection Microbiology, 2022
Proteases and their inhibitors play critical roles in host-parasite interactions and in the outcomes of infections. Ceratonova shasta is a myxozoan pathogen that causes enteronecrosis in economically important salmonids from the Pacific Northwest of ...
Gema Alama-Bermejo, Gema Alama-Bermejo, Pavla Bartošová-Sojková, Stephen D. Atkinson, Astrid S. Holzer, Jerri L. Bartholomew   +5 more
doaj   +1 more source

MHJ_0125 is an M42 glutamyl aminopeptidase that moonlights as a multifunctional adhesin on the surface of Mycoplasma hyopneumoniae [PDF]

Open Biology, 2013
Bacterial aminopeptidases play important roles in pathogenesis by providing a source of amino acids from exogenous proteins, destroying host immunological effector peptides and executing posttranslational modification of bacterial and host proteins.
Mark W. Robinson, Kyle A. Buchtmann, Cheryl Jenkins, Jessica L. Tacchi, Benjamin B. A. Raymond, Joyce To, Piklu Roy Chowdhury, Lauren K. Woolley, Maurizio Labbate, Lynne Turnbull, Cynthia B. Whitchurch, Matthew P. Padula, Steven P. Djordjevic   +12 more
doaj   +1 more source

Preparation and Characterization of an Ancient Aminopeptidase Obtained from Ancestral Sequence Reconstruction for L-Carnosine Synthesis

Molecules, 2022
As a biologically active peptide, L-carnosine has been widely used in the pharmaceutical, cosmetic and health care industries due to its various physiological properties.
Fan Liu, Yi Shi, Yakun Fang, Zhenshan Liu, Yu Xin, Zhenghua Gu, Zitao Guo, Liang Zhang   +7 more
doaj   +1 more source

Anti-Inflammatory and Antitumor Effects of Hydroxytyrosol but Not Oleuropein on Experimental Glioma In Vivo. A Putative Role for the Renin-Angiotensin System

Biomedicines, 2018
Functional roles of the angiotensin peptides of the renin-angiotensin system (RAS) cascade can be analyzed through their corresponding proteolytic regulatory enzymes aspartyl aminopeptidase (ASAP), aminopeptidase A (APA), aminopeptidase B (APB ...
María Jesús Ramírez-Expósito, José Manuel Martínez-Martos   +1 more
doaj   +1 more source

A Novel Function for the Streptococcus pneumoniae Aminopeptidase N: Inhibition of T Cell Effector Function through Regulation of TCR Signaling

Frontiers in Immunology, 2017
Streptococcus pneumoniae (Spn) causes a variety of disease states including fatal bacterial pneumonia. Our previous finding that introduction of Spn into an animal with ongoing influenza virus infection resulted in a CD8+ T cell population with reduced ...
Lance K. Blevins, Derek Parsonage, Melissa B. Oliver, Elizabeth Domzalski, W. Edward Swords, Martha A. Alexander-Miller   +5 more
doaj   +1 more source

IRAP Endosomes Control Phagosomal Maturation in Dendritic Cells

Frontiers in Cell and Developmental Biology, 2020
Dendritic cells (DCs) contribute to the immune surveillance by sampling their environment through phagocytosis and endocytosis. We have previously reported that, rapidly following uptake of extracellular antigen into phagosomes or endosomes in DCs, a ...
Mirjana Weimershaus, François-Xavier Mauvais, Irini Evnouchidou, Irini Evnouchidou, Myriam Lawand, Loredana Saveanu, Peter van Endert   +6 more
doaj   +1 more source

Aminopeptidase A [PDF]

Hypertension, 2008
Several decades of investigation have provided unequivocal support for the existence of an intrinsic brain renin-angiotensin (Ang) system (RAS) and its involvement in the control of cardiovascular functions.1,2 Essential components of the RAS, ie, renin, angiotensinogen, Ang-converting enzyme, Ang-converting enzyme 2, type 1 Ang II, and type 2 Ang II ...
Anderson J. Ferreira, Mohan K. Raizada
openaire   +1 more source

Evaluation of a Novel Chromogenic Medium for the Detection of Pseudomonas aeruginosa in Respiratory Samples from Patients with Cystic Fibrosis

Microorganisms, 2022
Pseudomonas aeruginosa is a dominant cause of respiratory infection in individuals with cystic fibrosis (CF), leading to significant morbidity and mortality. Detection of P.
Thang V. Truong, Alexander Twist, Andrey Zaytsev, Emma C. L. Marrs, Audrey Perry, Graeme Turnbull, Sylvain Orenga, Stephen P. Stanforth, John D. Perry   +8 more
doaj   +1 more source

Reciprocal Expression Patterns of Placental Leucine Aminopeptidase/Insulin-Regulated Aminopeptidase and Vasopressin in the Murine Brain

Frontiers in Molecular Biosciences, 2020
Placental leucine aminopeptidase/insulin-regulated aminopeptidase (P-LAP/IRAP) regulates vasopressin and oxytocin levels in the brain and peripheral tissues by controlled degradation of these peptides.
Yoshikuni Goto, Takahiro J. Nakamura, Kenji Ogawa, Akira Hattori, Masafumi Tsujimoto   +4 more
doaj   +1 more source

Combined angiotensin-converting enzyme and aminopeptidase inhibition for treatment of experimental ventilator-induced lung injury in mice

Frontiers in Physiology, 2023
Introduction: Ventilator-induced lung injury (VILI) may aggravate critical illness. Although angiotensin-converting enzyme (ACE) inhibition has beneficial effects in ventilator-induced lung injury, its clinical application is impeded by concomitant ...
Xinjun Mao, Xinjun Mao, Verena Tretter, Yi Zhu, Yi Zhu, Felix Kraft, Benjamin Vigl, Marko Poglitsch, Roman Ullrich, Roman Ullrich, Dietmar Abraham, Katharina Krenn   +11 more
doaj   +1 more source