Results 11 to 20 of about 61,885 (239)

A Bifunctional Protease Cleaves the Leader Peptide in the Biosynthesis of Class I Microviridins. [PDF]

Chembiochem
Biochemical characterization of the peptidase candidate NosP reveals bifunctional endo‐ and aminopeptidase activity in the leader peptide removal of class I microviridins from Nostoc punctiforme. The discovery of the first leader‐processing peptidase from microviridin biosynthesis may pave the way for the efficient production and bioengineering of ...
Brüssow N, Scholz S, Stindt A, Wiebach V, Damaszek T, Süssmuth RD, Dittmann E, Baunach M.   +7 more
europepmc   +2 more sources

MHJ_0125 is an M42 glutamyl aminopeptidase that moonlights as a multifunctional adhesin on the surface of Mycoplasma hyopneumoniae [PDF]

Open Biology, 2013
Bacterial aminopeptidases play important roles in pathogenesis by providing a source of amino acids from exogenous proteins, destroying host immunological effector peptides and executing posttranslational modification of bacterial and host proteins.
Mark W. Robinson, Kyle A. Buchtmann, Cheryl Jenkins, Jessica L. Tacchi, Benjamin B. A. Raymond, Joyce To, Piklu Roy Chowdhury, Lauren K. Woolley, Maurizio Labbate, Lynne Turnbull, Cynthia B. Whitchurch, Matthew P. Padula, Steven P. Djordjevic   +12 more
doaj   +1 more source

Preparation and Characterization of an Ancient Aminopeptidase Obtained from Ancestral Sequence Reconstruction for L-Carnosine Synthesis

Molecules, 2022
As a biologically active peptide, L-carnosine has been widely used in the pharmaceutical, cosmetic and health care industries due to its various physiological properties.
Fan Liu, Yi Shi, Yakun Fang, Zhenshan Liu, Yu Xin, Zhenghua Gu, Zitao Guo, Liang Zhang   +7 more
doaj   +1 more source

The Discovery of Insulin-Regulated Aminopeptidase (IRAP) Inhibitors: A Literature Review

Frontiers in Pharmacology, 2020
Insulin-Regulated Aminopeptidase (IRAP, EC 3.4.11.3) is a multi-tasking member of the M1 family of zinc aminopeptidases. Among its diverse biological functions, IRAP is a regulator of oxytocin levels during late stages of pregnancy, it affects cellular ...
Dimitris Georgiadis, Angeliki Ziotopoulou, Eleni Kaloumenou, Angelos Lelis, Antonia Papasava   +4 more
doaj   +1 more source

A New Colorimetric Assay for Methionyl Aminopeptidases: Examination of the Binding of a New Class of Pseudopeptide Analog Inhibitors [PDF]

, 2006
A direct and convenient spectrophotometric assay has been developed for methionine aminopeptidases (MetAPs). The method employs the hydrolysis of a substrate that is a methionyl analogue of p-nitroaniline (l-Met-p-NA), which releases the chromogenic ...
Dygas-Holz, Anna M., Holz, Richard C., Jiracek, Jiri, Mitra, Sanghamitra, Zakova, Lenka, Zertova, Miroslava   +5 more
core   +2 more sources

Depth-Resolved Variations of Cultivable Bacteria and Their Extracellular Enzymes in the Water Column of the New Britain Trench

Frontiers in Microbiology, 2018
Marine microorganisms and their extracellular enzymes (ECEs) play an important role in the remineralization of organic material by hydrolyzing high-molecular-weight substrates to sizes sufficiently small to be transported through cell membrane, yet the ...
Qianfeng Liu, Jiasong Fang, Jiasong Fang, Jiasong Fang, Jiangtao Li, Li Zhang, Bin-Bin Xie, Xiu-Lan Chen, Yu-Zhong Zhang, Yu-Zhong Zhang   +9 more
doaj   +1 more source

An M29 Aminopeptidase from Listeria Monocytogenes Contributes to In Vitro Bacterial Growth but not to Intracellular Infection

Microorganisms, 2020
Aminopeptidases that catalyze the removal of N-terminal residues from polypeptides or proteins are crucial for physiological processes. Here, we explore the biological functions of an M29 family aminopeptidase II from Listeria monocytogenes (LmAmpII). We
Xian Zhang, Chiyu Guan, Yi Hang, Fengdan Liu, Jing Sun, Huifei Yu, Li Gan, Huan Zeng, Yiran Zhu, Zhongwei Chen, Houhui Song, Changyong Cheng   +11 more
doaj   +1 more source

IRAP Endosomes Control Phagosomal Maturation in Dendritic Cells

Frontiers in Cell and Developmental Biology, 2020
Dendritic cells (DCs) contribute to the immune surveillance by sampling their environment through phagocytosis and endocytosis. We have previously reported that, rapidly following uptake of extracellular antigen into phagosomes or endosomes in DCs, a ...
Mirjana Weimershaus, François-Xavier Mauvais, Irini Evnouchidou, Irini Evnouchidou, Myriam Lawand, Loredana Saveanu, Peter van Endert   +6 more
doaj   +1 more source

Evaluation of a Novel Chromogenic Medium for the Detection of Pseudomonas aeruginosa in Respiratory Samples from Patients with Cystic Fibrosis

Microorganisms, 2022
Pseudomonas aeruginosa is a dominant cause of respiratory infection in individuals with cystic fibrosis (CF), leading to significant morbidity and mortality. Detection of P.
Thang V. Truong, Alexander Twist, Andrey Zaytsev, Emma C. L. Marrs, Audrey Perry, Graeme Turnbull, Sylvain Orenga, Stephen P. Stanforth, John D. Perry   +8 more
doaj   +1 more source

Reciprocal Expression Patterns of Placental Leucine Aminopeptidase/Insulin-Regulated Aminopeptidase and Vasopressin in the Murine Brain

Frontiers in Molecular Biosciences, 2020
Placental leucine aminopeptidase/insulin-regulated aminopeptidase (P-LAP/IRAP) regulates vasopressin and oxytocin levels in the brain and peripheral tissues by controlled degradation of these peptides.
Yoshikuni Goto, Takahiro J. Nakamura, Kenji Ogawa, Akira Hattori, Masafumi Tsujimoto   +4 more
doaj   +1 more source