Results 31 to 40 of about 29,120 (189)
The role of insulin-regulated aminopeptidase in MHC class I antigen presentation
Frontiers in Immunology, 2012 Production of MHC I ligands from antigenic proteins generally requires multiple proteolytic events. While the proteolytic steps required for antigen processing in the endogenous pathway are clearly established, persisting gaps of knowledge regarding ...
Peter M Van Endert, Loredana eSaveanu
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Frontiers in Microbiology, 2018 Marine microorganisms and their extracellular enzymes (ECEs) play an important role in the remineralization of organic material by hydrolyzing high-molecular-weight substrates to sizes sufficiently small to be transported through cell membrane, yet the ...
Qianfeng Liu +9 more
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Pharmaceuticals, 2021 Insulin-Regulated aminopeptidase (IRAP) is a zinc-dependent aminopeptidase with several important biological functions and is an emerging pharmaceutical target for cognitive enhancement and immune system regulation.
Ioannis Temponeras +3 more
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Aminopeptidase C of Aspergillus niger Is a Novel Phenylalanine Aminopeptidase [PDF]
Applied and Environmental Microbiology, 2003 ABSTRACT A novel enzyme with a specific phenylalanine aminopeptidase activity (ApsC) from Aspergillus niger (CBS 120.49) has been characterized. The derived amino acid sequence is not similar to any previously characterized aminopeptidase sequence but does share similarity with some mammalian acyl-peptide ...
Basten, E.J.W. +2 more
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Laeverin/Aminopeptidase Q, a Novel Bestatin-sensitive Leucine Aminopeptidase Belonging to the M1 Family of Aminopeptidases [PDF]
Journal of Biological Chemistry, 2007 Laeverin/aminopeptidase Q (APQ) is a cell surface protein specifically expressed on human embryo-derived extravillous trophoblasts that invades the uterus during placentation. The cDNA cloning of Laeverin/APQ revealed that the sequence encodes a protein with 990 amino acid residues, and Laeverin/APQ contains the HEXXHX(18)E gluzincin motif, which is ...
Masato, Maruyama +6 more
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IRAP Inhibitors: M1-Aminopeptidase Family Inspiration
Frontiers in Pharmacology, 2020 The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer’s disease and immune disorders.
Nicholas Barlow, Philip E. Thompson
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Study on preparation technology of low-phenylalanine perilla peptide
浙江大学学报. 农业与生命科学版, 2023 To enrich low-phenylalanine formula food for special medical purposes, this study used perilla defatted seed meal as the raw material to optimize the double enzymatic hydrolysis process through single factor and response surface analysis, while exploring
ZHANG Tianwei +4 more
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Metallopeptidases of Toxoplasma gondii: in silico identification and gene expression
Parasite, 2018 Metallopeptidases are a family of proteins with domains that remain highly conserved throughout evolution. These hydrolases require divalent metal cation(s) to activate the water molecule in order to carry out their catalytic action on peptide bonds by ...
Escotte-Binet Sandie +6 more
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Sociobiology, 2018 Aminopeptidases are enzymes that cleave the N-terminal region of proteins and show structural conservation in prokaryotes and eukaryotes. We aimed to identify leucine-aminopeptidase A (LAP-A) orthologs in the genome of bee species with diff erent levels ...
Luana Bataglia +3 more
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Development of a Bestatin-SAHA Hybrid with Dual Inhibitory Activity against APN and HDAC
Molecules, 2020 With five histone deacetylase (HDAC) inhibitors approved for cancer treatment, proteolysis-targeting chimeras (PROTACs) for degradation of HDAC are emerging as an alternative strategy for HDAC-targeted therapeutic intervention.
Jiangying Cao +7 more
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