Results 71 to 80 of about 41,379 (247)

Proteomic Analysis of Mixed Cell Membrane Extracts From Triple‐Negative Breast Cancer Cell Lines Revealed Broad Metabolic Reprogramming Associated With Tumor Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca, Violeta Larios‐Serrato, María Luisa Labra‐Barrios, Emmanuel Ríos‐Castro, Carlos Alberto Castañón‐Sánchez, Rodolfo Moreno‐Castillo, Erika Beatriz Ángeles‐Morales, Juan Pedro Luna‐Arias   +7 more
wiley   +1 more source

Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus

Pest Management Science, EarlyView.
Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano, Carmen Scieuzo, Rosanna Salvia, Riccardo Moretti, Flora Cozzolino, Maria Monti, Heiko Vogel, Patrizia Falabella   +7 more
wiley   +1 more source

Polymorphic positions 349 and 725 of the autoimmunity-protective allotype 10 of ER aminopeptidase 1 are key in determining its unique enzymatic properties

Frontiers in Immunology
IntroductionER aminopeptidase 1 (ERAP1) is a polymorphic intracellular aminopeptidase with key roles in antigen presentation and adaptive immune responses.
Galateia Georgaki, Galateia Georgaki, Anastasia Mpakali, Anastasia Mpakali, Myrto Trakada, Athanasios Papakyriakou, Efstratios Stratikos, Efstratios Stratikos   +7 more
doaj   +1 more source

Goose herbivory alters soil microbial community functional potential in a sub‐Arctic wetland

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Herbivory alters below‐ground resource dynamics via direct and indirect mechanisms, yet its effects on microbial functional potential remain poorly understood. This limits our understanding of the mechanisms that link animal, plant and microbial functional roles in ...
Jaron Adkins, Bonnie G. Waring, Karen H. Beard, Ryan T. Choi, Taylor Saunders, Emily A. Chavez, Lindsay R. Miller, Edd Hammill, Trisha B. Atwood   +8 more
wiley   +1 more source

Plant invasion in mountain ecosystems reduces soil micro‐food web complexity at higher elevations

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Anthropogenic activities have accelerated plant invasions in mountain ecosystems, impacting the structure and functions of native plant communities. Changes in above‐ground vegetation can drive shifts in below‐ground biota, yet the effects of plant invasions on soil ...
Runjie Jiao, Yunjian Xu, Xiao Xu, Yi Wang, Jihua Wu, Xiaoli Cheng, Rongzhen Liu, Bo Li, Yupeng Geng   +8 more
wiley   +1 more source

From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase

Frontiers in Pharmacology, 2020
It was reported three decades ago that intracerebroventricular injection of angiotensin IV (Ang IV, Val-Tyr-Ile-His-Pro-Phe) improved memory and learning in the rat. There are several explanations for these positive effects of the hexapeptide and related
Mathias Hallberg, Mats Larhed
doaj   +1 more source

Monospecific cover crops perpetuate soil biotic homogenization in croplands across diverse soils

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Croplands are known to support significant soil biotic homogenization. Cover crops are commonly used as a sustainable agriculture practice; however, many times these cover crops are composed of single‐species.
Sibo Shi, Teng Yang, Xin Gong, Saisai Cheng, Xiaoyun Chen, Xianping Li, Manuel Delgado‐Baquerizo, Linchuan Fang, Manqiang Liu   +8 more
wiley   +1 more source

d-Aminopeptidase DppA

The subject of this chapter is d-aminopeptidase DppA. DppA is a cocatalytic zinc metallopeptidase that releases a d-amino acid from the N-terminus of a peptide. It has been characterized as Bacillus subtilis.
Remaut, Han, Goffin, Colette
core   +1 more source

On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity

mBio
To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum and Plasmodium ...
Rebecca C. S. Edgar, Tess R. Malcolm, Ghizal Siddiqui, Carlo Giannangelo, Natalie A. Counihan, Matthew Challis, Sandra Duffy, Mrittika Chowdhury, Jutta Marfurt, Madeline Dans, Grennady Wirjanata, Rintis Noviyanti, Kajal Daware, Chathura D. Suraweera, Ric N. Price, Sergio Wittlin, Vicky M. Avery, Nyssa Drinkwater, Susan A. Charman, Darren J. Creek, Tania F. de Koning-Ward, Peter J. Scammells, Sheena McGowan   +22 more
doaj   +1 more source

Saline versus alkaline stresses in paddy soils drive divergent microbial nutrient limitations despite shared carbon constraints

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Soil salinization and alkalization often suppress microbial functional activity, triggering negative feedback loops in microbial metabolism, degrading nutrients and agricultural productivity.
Yuqi Chen, Lingying Xu, Xu Zhao
wiley   +1 more source