Results 71 to 80 of about 1,233 (154)

Leucine Aminopeptidase from Xanthomonas oryzae pv. oryzae with Esterase Activity Toward Heroin: Biochemical and Catalytic Insights

Biomolecules
Heroin is a highly addictive drug that exerts its primary effects through activation of μ-opioid receptors. Its principal active metabolite, 6-monoacetylmorphine (6-MAM), significantly contributes to heroin’s neurological effects and acute toxicity ...
Hualing Li, Qi Hu, Nuo Xu, Xueting Shao, Yuxin Liu, Yuxin Hou, Binjie Wang, Jiye Wang, Jianzhuang Yao, Shurong Hou, Xiabin Chen   +10 more
doaj   +1 more source

Bio‐organic fertilizer alleviated soil microbial C limitations, aggravated P limitations and increased microbial C use efficiency in a degraded desert steppe

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Bio‐organic fertilizer (BOF), which integrates organic carbon sources, beneficial microorganisms and essential nutrients, represents a distinctive approach to grassland restoration that differs fundamentally from conventional fertilization practices.
Yao Zhou, Wen Li, Jing Ma, Jinzhen Li, Haixin Jiang, Guohui Wang, Yan Shen, Hongbin Ma   +7 more
wiley   +1 more source

From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase

Frontiers in Pharmacology, 2020
It was reported three decades ago that intracerebroventricular injection of angiotensin IV (Ang IV, Val-Tyr-Ile-His-Pro-Phe) improved memory and learning in the rat. There are several explanations for these positive effects of the hexapeptide and related
Mathias Hallberg, Mats Larhed
doaj   +1 more source

On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity

mBio
To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum and Plasmodium ...
Rebecca C. S. Edgar, Tess R. Malcolm, Ghizal Siddiqui, Carlo Giannangelo, Natalie A. Counihan, Matthew Challis, Sandra Duffy, Mrittika Chowdhury, Jutta Marfurt, Madeline Dans, Grennady Wirjanata, Rintis Noviyanti, Kajal Daware, Chathura D. Suraweera, Ric N. Price, Sergio Wittlin, Vicky M. Avery, Nyssa Drinkwater, Susan A. Charman, Darren J. Creek, Tania F. de Koning-Ward, Peter J. Scammells, Sheena McGowan   +22 more
doaj   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Role of insulin-regulated aminopeptidase as potential biomarker in insulin resistant polycystic ovary syndrome patients [PDF]

Archives of Endocrinology and Metabolism
Objective: To measure serum insulin-regulated aminopeptidase levels in women diagnosed with polycystic ovary syndrome and to investigate their potential contribution of these levels to the development of insulin resistance, which plays a central role in ...
Osman Köse, Koray Gök, Elif Köse, Sezen Irmak Gözükara, Abdullah Tüten, Mehmet Sühha Bostancı   +5 more
doaj   +2 more sources

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

Aminopeptidases do not directly degrade tau protein

Molecular Neurodegeneration, 2010
Background Tau hyperphosphorylation and aggregation to form intracellular neurofibrillar tangles is prevalent in a number of tauopathies. Thus there is current interest in the mechanisms involved in Tau clearance. It was recently reported that Tau can be
Hersh Louis B, Guan Hanjun, Chow K
doaj   +1 more source

Genetic Parameters and Genome‐Wide Association Studies for Fertility and Reproduction Traits in U.S. Katahdin Sheep Based on the Single‐Step GBLUP Methodology

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Sheep production contributes to a secure and diverse food and fibre supply in the United States, with growing ethnic diversity strengthening demand. Katahdin is a composite hair‐type sheep breed developed in the United States that has become the most popular breed in many regions of the country and the first one to have genomic selection ...
Alejandra Toro Ospina, Ronald M. Lewis, Bradley A. Freking, Joan M. Burke, Thomas W. Murphy, Carrie S. Wilson, Luiz F. Brito   +6 more
wiley   +1 more source

Purification and partial characterization of Phaseolus vulgaris seed aminopeptidase

Brazilian Journal of Medical and Biological Research, 1999
The aminopeptidase activity of Phaseolus vulgaris seeds was measured using L-Leu-p-nitroanilide and the L-aminoacyl-ß-naphthylamides of Leu, Ala, Arg and Met.
A.P. Abdala, L.H. Takeda, J.O. Freitas Jr., K.B. Alves   +3 more
doaj   +1 more source