Results 81 to 90 of about 40,140 (225)

Functional analysis of leucine aminopeptidase in Caenorhabditis elegans.

, 2001
To investigate the function of the enzyme leucine aminopeptidase in nematodes, a Caenorhabditis elegans leucine aminopeptidase gene identified in the genome sequence was functionally analysed by transfection of a leucine aminopeptidase beta-galactosidase
Joshua, GW
core   +1 more source

From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase

Frontiers in Pharmacology, 2020
It was reported three decades ago that intracerebroventricular injection of angiotensin IV (Ang IV, Val-Tyr-Ile-His-Pro-Phe) improved memory and learning in the rat. There are several explanations for these positive effects of the hexapeptide and related
Mathias Hallberg, Mats Larhed
doaj   +1 more source

Extracellular Aminopeptidase Production

, 1971
The mode of aminopeptidase production was studied in Gramvariable Bacillus subtilis cultures. This microorganism exhibited at least three peptidolytic activities: (a) an extracellular endopeptidase produced during logarithmic growth, (b) an ...
Chung, Amy Mai-Yan
core  

Biliary aminopeptidase-N and the cholesterol crystallization defect in cholelithiasis

, 1995
Several biliary proteins have cholesterol crystallisation promoting activity. One of these glycoproteins is aminopeptidase-N, a canalicular ectoenzyme. This study attempted to localise aminopeptidase-N along the biliary tree, to assess its concentration ...
Mingrone, G., Greco, A., Núñez, L., Pimentel González, Eduardo Fernando, Garrido Negri, Jorge, Nervi Oddone, Flavio, Rigotti Rivera, Attilio Gianpietro, Puglielli, L., Amigo Boker, Ludwig Peter, Raddatz Echavarría, Alejandro, González, S., Miquel Poblete, Juan Francisco   +11 more
core   +1 more source

On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity

mBio
To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum and Plasmodium ...
Rebecca C. S. Edgar, Tess R. Malcolm, Ghizal Siddiqui, Carlo Giannangelo, Natalie A. Counihan, Matthew Challis, Sandra Duffy, Mrittika Chowdhury, Jutta Marfurt, Madeline Dans, Grennady Wirjanata, Rintis Noviyanti, Kajal Daware, Chathura D. Suraweera, Ric N. Price, Sergio Wittlin, Vicky M. Avery, Nyssa Drinkwater, Susan A. Charman, Darren J. Creek, Tania F. de Koning-Ward, Peter J. Scammells, Sheena McGowan   +22 more
doaj   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors

, 2017
Leukotriene A4 Hydrolase (LTA4H) is a bifunctional zinc metalloenzyme that comprises both epoxide hydrolase and aminopeptidase activity, exerted by two overlapping catalytic sites.
Penno, CA, Petra Jäger, Liz Hardaker, Claire Laguerre, Röthlisberger, P, Jäger, P, Arnaud Osmont, Houguenade, J, Shin Numao, Bergsdorf, C, Carte, N, Numao, S, Andreas Hofmann, Billich, A, Carlos A. Penno, Patrik Röthlisberger, Romain M. Wolf, Osmont, A, Hardaker, L, Andres Schmid, Jeremy Houguenade, Hasler, F, Honnappa Srinivas, Wack, N, Franziska Hasler, Hofmann, A, Miltz, W, Janet Dawson, Till A. Röhn, Andreas Billich, Birgit Bollbuck, Markert, C, Nathalie Carte, Dawson, J, Laguerre, C, Srinivas, H, Wolf, RM, Nathalie Wack, Wolfgang Miltz, Röhn, TA, Christian Bergsdorf, Christian Markert, Schmid, A, Bollbuck, B   +43 more
core   +1 more source

TRIM59 Drives Bladder Cancer Progression Through E3 Ligase‐Dependent K48‐Linked Degradation of PTRF

Cancer Science, EarlyView.
Schematic model of TRIM59‐driven BLCA progression through K48‐linked ubiquitination and proteasomal degradation of PTRF, leading to AKT activation and c‐Myc upregulation. ABSTRACT Tripartite motif‐containing 59 (TRIM59) is an E3 ubiquitin ligase implicated in multiple malignancies, but its role in bladder cancer (BLCA) remains incompletely understood ...
Junlin Gan, Xuesong Bai, Aijie Zhang, Fei Lin, Hang Tong, Tinghao Li, Ning Xu, Xinyuan Li, Zhou Yu, Hubin Yin   +9 more
wiley   +1 more source

Aminopeptidases do not directly degrade tau protein

Molecular Neurodegeneration, 2010
Background Tau hyperphosphorylation and aggregation to form intracellular neurofibrillar tangles is prevalent in a number of tauopathies. Thus there is current interest in the mechanisms involved in Tau clearance. It was recently reported that Tau can be
Hersh Louis B, Guan Hanjun, Chow K
doaj   +1 more source

Pemafibrate Improves Cholestatic Markers Regardless of the Presence of Primary Biliary Cholangitis

Hepatology Research, EarlyView.
Pemafibrate improves liver function markers related to bile flow in primary biliary cholangitis (PBC), but whether this effect is disease‐specific remains unclear. In this study, pemafibrate reduced these markers in patients with and without PBC, suggesting broader effects on bile flow beyond PBC.
Ryohei Tanigawa, Yoshiyuki Ueno, Hirokazu Takahashi, Ayumi Saito, Hideki Suganami, Atsushi Tanaka   +5 more
wiley   +1 more source