Results 81 to 90 of about 41,379 (247)

Fluorescence generation from aminopeptidase activity (AA = amino acid).

, 2016
Fluorescence generation from aminopeptidase activity (AA = amino acid).
Stephen P. Stanforth (3156171), Arthur L. James (2638357), John D. Perry (452417), Sylvain Orenga (2638360), Graeme Turnbull (3156168), Marie Cellier (2638363)   +5 more
core   +1 more source

Characterization of a leucine aminopeptidase from Toxoplasma gondii [PDF]

, 2010
application/pdfThe M17 family leucine aminopeptidase (LAP) hydrolyze amino acids from the N-terminus of peptides. Many LAPs from parasitic protozoa including Plasmmodium, Trypanosoma and Leishmania, have been intensely investigated because of their ...
Nishikawa, Yoshifumi, Yamagishi, Junya, 山岸, 潤也, Luo, Yuzi, 杉本, 千尋, Xuan, Xuenan, Jia, Honglin, 玄, 学南, Sugimoto, Chihiro, 西川, 義文   +9 more
core   +1 more source

Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors [PDF]

, 2017
Leukotriene A4 Hydrolase (LTA4H) is a bifunctional zinc metalloenzyme that comprises both epoxide hydrolase and aminopeptidase activity, exerted by two overlapping catalytic sites.
Penno, CA, Petra Jäger, Liz Hardaker, Claire Laguerre, Röthlisberger, P, Jäger, P, Arnaud Osmont, Houguenade, J, Shin Numao, Bergsdorf, C, Carte, N, Numao, S, Andreas Hofmann, Billich, A, Carlos A. Penno, Patrik Röthlisberger, Romain M. Wolf, Osmont, A, Hardaker, L, Andres Schmid, Jeremy Houguenade, Hasler, F, Honnappa Srinivas, Wack, N, Franziska Hasler, Hofmann, A, Miltz, W, Janet Dawson, Till A. Röhn, Andreas Billich, Birgit Bollbuck, Markert, C, Nathalie Carte, Dawson, J, Laguerre, C, Srinivas, H, Wolf, RM, Nathalie Wack, Wolfgang Miltz, Röhn, TA, Christian Bergsdorf, Christian Markert, Schmid, A, Bollbuck, B, Miltz, Wolfgang (author), Jäger, Petra (author), Hasler, Franziska (author), Schmid, Andres (author), Hardaker, Liz (author), Srinivas, Honnappa (author), Bergsdorf, Christian (author), Wolf, Romain M. (author), Houguenade, Jeremy (author), Osmont, Arnaud (author), Billich, Andreas (author), Markert, Christian (author), Wack, Nathalie (author), Dawson, Janet (author), Laguerre, Claire (author), Numao, Shin (author), Penno, Carlos A. (author), Bollbuck, Birgit (author), Röthlisberger, Patrik (author), Carte, Nathalie (author), Röhn, Till A. (author), Hofmann, Andreas (author)   +65 more
core   +1 more source

A comparative study on the rectal aminopeptidase enzymatic activities of different species

, 2003
The aim of the present study was to compare the enzymatic activity of four different aminopeptidases (aminopeptidase N, leucine aminopeptidase, aminopeptidase A, aminopeptidase B), in rectal homogenates from different species: rabbit, rat, guinea-pig ...
Parlatan, ZI, Acarturk, FÜSUN
core   +1 more source

IgE‐Binding Bacterial Components Not Yet Documented in the Allergen Databases and Their Allergenic Mechanisms: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Among bacteria that are associated with the development and/or exacerbation of allergic/atopic diseases, several have been described to produce IgE‐binding components. However, only one bacterial protein, Bac s 1, is currently listed in the official database of the World Health Organization/International Union of Immunological Societies (WHO ...
Uta Jappe, Marua Abu Risha, Ioana Agache, Claus Bachert, Barbara Bröker, Riccardo Castagnoli, Gabriele Gadermaier, Richard E. Goodman, Amir Guemari, Christiane Hilger, Alain Jacquet, Sabine Kespohl, Ludger Klimek, Annette Kuehn, Jonas Lidholm, Vera Mahler, Markus Ollert, Thomas A. Platts‐Mills, Monika Raulf, Peter Schmid‐Grendelmeier, Frieder Schmiedeke, Marianne van Hage, Joana Vitte, Josefina Zakzuk, Anna Pomés   +24 more
wiley   +1 more source

Ketomethylenebestatin: Synthesis and aminopeptidase inhibition

, 2023
The synthesis of (6R,5S,2RS)-6-amino-5-hydroxy-2-isobutyl-4-oxo-7-phenylheptanoic acid (9), a carbaanalogue of the aminopeptidase (AP) inhibitor bestatin (1) is described.
Castro-Pichel, J., Pérez, Concepción, Herranz, Rosario, Gómez-Monterrey, Isabel, Vinuesa, Soledad, García-López, M. Teresa   +5 more
core   +1 more source

Aminopeptidases do not directly degrade tau protein

Molecular Neurodegeneration, 2010
Background Tau hyperphosphorylation and aggregation to form intracellular neurofibrillar tangles is prevalent in a number of tauopathies. Thus there is current interest in the mechanisms involved in Tau clearance. It was recently reported that Tau can be
Hersh Louis B, Guan Hanjun, Chow K
doaj   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Purification and partial characterization of Phaseolus vulgaris seed aminopeptidase

Brazilian Journal of Medical and Biological Research, 1999
The aminopeptidase activity of Phaseolus vulgaris seeds was measured using L-Leu-p-nitroanilide and the L-aminoacyl-ß-naphthylamides of Leu, Ala, Arg and Met.
A.P. Abdala, L.H. Takeda, J.O. Freitas Jr., K.B. Alves   +3 more
doaj   +1 more source

Positive modulation of glucagon‐like peptide 1 (GLP‐1) receptor by endogenous haemorphins with implications in glucose metabolism and diabetes

British Journal of Pharmacology, EarlyView.
Haemorphins act on GLP‐1 receptor (GLP‐1R) activity and signalling in a positive allosteric manner. This leads to potentiated GLP‐1‐mediated activity and signalling, as well as insulin synthesis, which may have implications for glucose metabolism and, thereby, diabetes and obesity. (The graph was created in BioRender.com).
Farheen Badrealam Khan, Rwdah Mohamed Alameri, Yasir S. Raouf, Damien Maurel, Naiem Ahmad Wani, Anatoliy Shmygol, Irfa Anwar, Heng B. See, Elizabeth K. M. Johnstone, Elodie Dupuis, Eric Trinquet, Kevin D. G. Pfleger, Emilia Oueis, Mohammed Akli Ayoub   +13 more
wiley   +1 more source