Results 21 to 30 of about 13,225 (225)
Frontiers in Cellular and Infection Microbiology, 2023 We have previously demonstrated that deletion of an intracellular leucine aminopeptidase results in attenuated virulence of S. aureus. Herein we explore the role of 10 other aminopeptidases in S. aureus pathogenesis. Using a human blood survival assay we
Nathanial J. Torres +7 more
doaj +1 more source
Omics assisted N-terminal proteoform and protein expression profiling on methionine aminopeptidase 1 (MetAP1) deletion [PDF]
, 2018 Excision of the N-terminal initiator methionine (iMet) residue from nascent peptide chains is an essential and omnipresent protein modification carried out by methionine aminopeptidases (MetAPs) that accounts for a major source of N-terminal proteoform ...
Fijalkowska, Daria +2 more
core +1 more source
Peptidolytic enzymes in different larval stadium of housefly Musca domestica
Veterinární Medicína, 2006 Four classes of peptidolytic enzymes were described in insects. Many authors have found predominant activity belonging to trypsin-like and chymotrypsin-like activity.
J. Blahovec, Z. Kostecka, A. Kocisova
doaj +1 more source
Characterization of aminopeptidase encoding gene anp-1 and its association with development in Caenorhabditis elegans [PDF]
PeerJ, 2019 Background Aminopeptidases play important roles in various biological processes in nematodes including growth, development and reproduction. Although the aminopeptidases have been shown to regulate reproduction in Caenorhabditis elegans (C. elegans), the
Shanchun Su +3 more
doaj +2 more sources
A New Colorimetric Assay for Methionyl Aminopeptidases: Examination of the Binding of a New Class of Pseudopeptide Analog Inhibitors [PDF]
, 2006 A direct and convenient spectrophotometric assay has been developed for methionine aminopeptidases (MetAPs). The method employs the hydrolysis of a substrate that is a methionyl analogue of p-nitroaniline (l-Met-p-NA), which releases the chromogenic ...
Dygas-Holz, Anna M. +5 more
core +2 more sources
Klotho and Aminopeptidases as Early Biomarkers of Renal Injury in Zucker Obese Rats
Frontiers in Physiology, 2018 The aim of this study was to investigate if urinary glutamyl aminopeptidase (GluAp), alanyl aminopeptidase (AlaAp), Klotho and hydroxyproline can be considered as potential biomarkers of renal injury and fibrosis in an experimental model of obesity. Male
Sebastián Montoro-Molina +10 more
doaj +1 more source
G3: Genes, Genomes, Genetics, 2021 Puromycin-sensitive aminopeptidases are found across phyla and are known to regulate the cell-cycle and play a protective role in neurodegenerative disease.
Dorothy Benton +10 more
doaj +1 more source
Frontiers in Endocrinology, 2018 Thyroid disorders affect the hypothalamic-pituitary-adrenal axis with important consequences on the cardiovascular function in which the renin-angiotensin system plays a major role.
Ana B. Segarra +5 more
doaj +1 more source
Biomolecules, 2020 Designing side chain substituents complementary to enzyme binding pockets is of great importance in the construction of potent and selective phosphinic dipeptide inhibitors of metallo-aminopeptidases.
Michał Talma, Artur Mucha
doaj +1 more source
HemaSphere, 2022 Immunoglobulin light-chain (AL) amyloidosis is a rare disease caused by clonal plasma cell secretion of misfolded light chains that assemble as toxic amyloid fibrils, depositing in vital organs including the heart and kidneys, causing organ dysfunction ...
Ken Flanagan +12 more
doaj +1 more source