Results 31 to 40 of about 8,322 (232)

Klotho and Aminopeptidases as Early Biomarkers of Renal Injury in Zucker Obese Rats

Frontiers in Physiology, 2018
The aim of this study was to investigate if urinary glutamyl aminopeptidase (GluAp), alanyl aminopeptidase (AlaAp), Klotho and hydroxyproline can be considered as potential biomarkers of renal injury and fibrosis in an experimental model of obesity. Male
Sebastián Montoro-Molina, Antonio López-Carmona, Andrés Quesada, Francisco O’Valle, Francisco O’Valle, Natividad Martín-Morales, Antonio Osuna, Antonio Osuna, Félix Vargas, Félix Vargas, Rosemary Wangensteen   +10 more
doaj   +1 more source

The Peptide–Drug Conjugate Melflufen Modulates the Unfolded Protein Response of Multiple Myeloma and Amyloidogenic Plasma Cells and Induces Cell Death

HemaSphere, 2022
Immunoglobulin light-chain (AL) amyloidosis is a rare disease caused by clonal plasma cell secretion of misfolded light chains that assemble as toxic amyloid fibrils, depositing in vital organs including the heart and kidneys, causing organ dysfunction ...
Ken Flanagan, Romika Kumari, Juho J. Miettinen, Staci L. Haney, Michelle L. Varney, Jacob T. Williams, Muntasir M. Majumder, Minna Suvela, Ana Slipicevic, Fredrik Lehmann, Nina N. Nupponen, Sarah A. Holstein, Caroline A. Heckman   +12 more
doaj   +1 more source

Aminopeptidase Activities Interact Asymmetrically between Brain, Plasma and Systolic Blood Pressure in Hypertensive Rats Unilaterally Depleted of Dopamine

Biomedicines, 2022
Brain dopamine, in relation to the limbic system, is involved in cognition and emotion. These functions are asymmetrically processed. Hypertension not only alters such functions but also their asymmetric brain pattern as well as their bilateral pattern ...
Inmaculada Banegas, Isabel Prieto, Ana Belén Segarra, Francisco Vives, Magdalena Martínez-Cañamero, Raquel Durán, Juan de Dios Luna, Germán Domínguez-Vías, Manuel Ramírez-Sánchez   +8 more
doaj   +1 more source

Laeverin/Aminopeptidase Q, a Novel Bestatin-sensitive Leucine Aminopeptidase Belonging to the M1 Family of Aminopeptidases [PDF]

Journal of Biological Chemistry, 2007
Laeverin/aminopeptidase Q (APQ) is a cell surface protein specifically expressed on human embryo-derived extravillous trophoblasts that invades the uterus during placentation. The cDNA cloning of Laeverin/APQ revealed that the sequence encodes a protein with 990 amino acid residues, and Laeverin/APQ contains the HEXXHX(18)E gluzincin motif, which is ...
Masato, Maruyama, Akira, Hattori, Yoshikuni, Goto, Masamichi, Ueda, Michiyuki, Maeda, Hiroshi, Fujiwara, Masafumi, Tsujimoto   +6 more
openaire   +2 more sources

Isolation and functional characterisation of microbial β-aminopeptidases

, 2019
β-Peptides, constituted of β-amino acids, are chemically synthesised molecules useful as biomaterials or therapeutics. β-Peptides form structures and have biological activity like naturally occurring peptides and are not easily broken down.
MARIETTA RUSHIKA JOHN-WHITE (6815942)
core   +1 more source

Influence of Condensed and Hydrolysable Tannins on the Bacterial Community, Protein Degradation, and Fermentation Quality of Alfalfa Silage

Animals, 2022
This study evaluated the effects of hydrolysable tannin (HT) and condensed tannin (CT) on the bacterial community, fermentation quality, and proteolysis of alfalfa silage.
Wencan Ke, Huan Zhang, Shengnan Li, Yanlin Xue, Yan Wang, Wencheng Dong, Yimin Cai, Guijie Zhang   +7 more
doaj   +1 more source

MHJ_0125 is an M42 glutamyl aminopeptidase that moonlights as a multifunctional adhesin on the surface of Mycoplasma hyopneumoniae [PDF]

Open Biology, 2013
Bacterial aminopeptidases play important roles in pathogenesis by providing a source of amino acids from exogenous proteins, destroying host immunological effector peptides and executing posttranslational modification of bacterial and host proteins.
Mark W. Robinson, Kyle A. Buchtmann, Cheryl Jenkins, Jessica L. Tacchi, Benjamin B. A. Raymond, Joyce To, Piklu Roy Chowdhury, Lauren K. Woolley, Maurizio Labbate, Lynne Turnbull, Cynthia B. Whitchurch, Matthew P. Padula, Steven P. Djordjevic   +12 more
doaj   +1 more source

AMINOPEPTIDASES FROM HUMAN-LEUKOCYTES

, 1984
RAUTENBERG W, Tschesche H. AMINOPEPTIDASES FROM HUMAN-LEUKOCYTES. HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE.
Wilfried RAUTENBERG, RAUTENBERG, W, Tschesche, Harald, Harald TSCHESCHE   +3 more
core   +1 more source

M1 aminopeptidases as drug targets:Broad applications or therapeutic niche? [PDF]

, 2017
M1 aminopeptidase enzymes are a diverse family of metalloenzymes characterized by conserved structure and reaction specificity. Excluding viruses, M1 aminopeptidases are distributed throughout all phyla, and have been implicated in a wide range of ...
McGowan, Sheena, Wei Yang, Nyssa Drinkwater, Jisook Lee, Lee, Jisook, Sheena McGowan, Tess R. Malcolm, Drinkwater, Nyssa, Yang, Wei, Malcolm, Tess R.   +9 more
core   +1 more source

An M29 Aminopeptidase from Listeria Monocytogenes Contributes to In Vitro Bacterial Growth but not to Intracellular Infection

Microorganisms, 2020
Aminopeptidases that catalyze the removal of N-terminal residues from polypeptides or proteins are crucial for physiological processes. Here, we explore the biological functions of an M29 family aminopeptidase II from Listeria monocytogenes (LmAmpII). We
Xian Zhang, Chiyu Guan, Yi Hang, Fengdan Liu, Jing Sun, Huifei Yu, Li Gan, Huan Zeng, Yiran Zhu, Zhongwei Chen, Houhui Song, Changyong Cheng   +11 more
doaj   +1 more source