Results 11 to 20 of about 13,303 (230)
Using microbial metalo-aminopeptidases as targets in human infectious diseases
Microbial Cell, 2021 Several microbial metalo-aminopeptidases are emerging as novel targets for the treatment of human infectious diseases. Some of them are well validated as targets and some are not; some are essential enzymes and others are important for virulence and ...
Jorge González-Bacerio +5 more
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An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes [PDF]
, 2018 The Endoplasmatic Reticulum Aminopeptidases ERAP1 and ERAP2 are implicated in a variety of immune and non-immune functions. Most studies however have focused on their role in shaping the HLA class I peptidome by trimming peptides to the optimal size ...
Cauli, A +7 more
core +2 more sources
Archives of Environmental Protection, 2015 Dobór technik bioremediacji jest bardzo ważny w oczyszczaniu gleby skażonej substancjami ropopochodnymi, która ma być wykorzystywanej rolniczo. Prezentowane wyniki wskazują, że na rozwój siewek owsa większy wpływ ma stosowana metoda bioremediacji niż ...
Pawełczak Małgorzata +5 more
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Co-Catalytic Metallopeptidases as Pharmaceutical Targets [PDF]
, 2003 Understanding the reaction mechanism of co-catalytic metallopeptidases provides a starting point for the design and synthesis of new molecules that can be screened as potential pharmaceuticals. Many of the enzymes that contain co-catalytic metallo-active
Bzymek, Krzysztof P. +2 more
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Genetic characterization of the peptidases of Polistes versicolor (Hymenoptera: Vespidae) [PDF]
Brazilian Journal of Biology, 2003 Starch gel electrophoresis with L-leucyl-beta-naphthylamide as substrate revealed five aminopeptidases in extracts of Polistes versicolor. These enzymes are presumably products of five structural gene loci.
M. A. Del Lama, K. M. Ferreira
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A New Colorimetric Assay for Methionyl Aminopeptidases: Examination of the Binding of a New Class of Pseudopeptide Analog Inhibitors [PDF]
, 2006 A direct and convenient spectrophotometric assay has been developed for methionine aminopeptidases (MetAPs). The method employs the hydrolysis of a substrate that is a methionyl analogue of p-nitroaniline (l-Met-p-NA), which releases the chromogenic ...
Dygas-Holz, Anna M. +5 more
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Marine Drugs, 2023 Proteolytic enzymes, also known as peptidases, are critical in all living organisms. Peptidases control the cleavage, activation, turnover, and synthesis of proteins and regulate many biochemical and physiological processes.
Isel Pascual Alonso +8 more
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Arginine specific aminopeptidase from Lactobacillus brevis
Brazilian Archives of Biology and Technology, 2010 The proteolytic system of lactic acid bacteria contribute to the development of flavor during the ripening of cheese through the generation of short peptides and free amino acids, which directly or indirectly act as flavor precursors.
Arya Nandan +3 more
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Frontiers in Cellular and Infection Microbiology, 2023 We have previously demonstrated that deletion of an intracellular leucine aminopeptidase results in attenuated virulence of S. aureus. Herein we explore the role of 10 other aminopeptidases in S. aureus pathogenesis. Using a human blood survival assay we
Nathanial J. Torres +7 more
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Omics assisted N-terminal proteoform and protein expression profiling on methionine aminopeptidase 1 (MetAP1) deletion [PDF]
, 2018 Excision of the N-terminal initiator methionine (iMet) residue from nascent peptide chains is an essential and omnipresent protein modification carried out by methionine aminopeptidases (MetAPs) that accounts for a major source of N-terminal proteoform ...
Fijalkowska, Daria +2 more
core +1 more source