Marine Invertebrates: A Promissory Still Unexplored Source of Inhibitors of Biomedically Relevant Metallo Aminopeptidases Belonging to the M1 and M17 Families [PDF]
Marine Drugs, 2023 Proteolytic enzymes, also known as peptidases, are critical in all living organisms. Peptidases control the cleavage, activation, turnover, and synthesis of proteins and regulate many biochemical and physiological processes.
Isel Pascual Alonso +8 more
doaj +2 more sources
Using microbial metalo-aminopeptidases as targets in human infectious diseases [PDF]
Microbial Cell, 2021 Several microbial metalo-aminopeptidases are emerging as novel targets for the treatment of human infectious diseases. Some of them are well validated as targets and some are not; some are essential enzymes and others are important for virulence and ...
Jorge González-Bacerio +5 more
doaj +2 more sources
Phosphonic Acid Analogues of Phenylglycine as Inhibitors of Aminopeptidases: Comparison of Porcine Aminopeptidase N, Bovine Leucine Aminopeptidase, Tomato Acidic Leucine Aminopeptidase and Aminopeptidase from Barley Seeds [PDF]
Pharmaceuticals, 2019 The inhibitory activity of 14 racemic phosphonic acid analogs of phenylglycine, substituted in aromatic rings, towards porcine aminopeptidase N (pAPN) and barley seed aminopeptidase was determined experimentally.
Weronika Wanat +3 more
doaj +3 more sources
Aminopeptidase C of Aspergillus niger Is a Novel Phenylalanine Aminopeptidase [PDF]
Applied and Environmental Microbiology, 2003 ABSTRACT A novel enzyme with a specific phenylalanine aminopeptidase activity (ApsC) from Aspergillus niger (CBS 120.49) has been characterized. The derived amino acid sequence is not similar to any previously characterized aminopeptidase sequence but does share similarity with some mammalian acyl-peptide ...
Basten, E.J.W. +2 more
openaire +5 more sources
Aminopeptidases of Germinated and Non-Germinated Barley
Food Technology and Biotechnology, 2009 In processes of barley plant development, various endo- and exopeptidases are involved. To determine the type and number of aminopeptidases that could participate in barley seed germination and tissue growth, their activities in extracts of non ...
Bojana Vukelić +2 more
doaj +1 more source
Aminopeptidases of malaria parasites:new targets for chemotherapy
, 2010 Novel targets for new drug development are urgently required to combat malaria, a disease that puts half of the world's population at risk. One group of enzymes identified within the genome of the most lethal of the causative agents of malaria ...
Brown, Christopher L. +22 more
core +5 more sources
Archives of Environmental Protection, 2015 Dobór technik bioremediacji jest bardzo ważny w oczyszczaniu gleby skażonej substancjami ropopochodnymi, która ma być wykorzystywanej rolniczo. Prezentowane wyniki wskazują, że na rozwój siewek owsa większy wpływ ma stosowana metoda bioremediacji niż ...
Pawełczak Małgorzata +5 more
doaj +1 more source
Human Aminopeptidases: A Review of the Literature [PDF]
, 1988 Summary: The aminopeptidases constitute a group of enzymes with closely related activities. In clinical chemistry the analysis of the aminopeptidases and of their multiple forms in serum has for a long time been hindered by considerable confusion ...
G. -j. S +5 more
core +1 more source
Genetic characterization of the peptidases of Polistes versicolor (Hymenoptera: Vespidae) [PDF]
Brazilian Journal of Biology, 2003 Starch gel electrophoresis with L-leucyl-beta-naphthylamide as substrate revealed five aminopeptidases in extracts of Polistes versicolor. These enzymes are presumably products of five structural gene loci.
M. A. Del Lama, K. M. Ferreira
doaj +1 more source
Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases. [PDF]
, 2021 During malarial infection, Plasmodium parasites digest human hemoglobin to obtain free amino acids for protein production and maintenance of osmotic pressure.
Malcolm, TR +6 more
core +1 more source