Results 11 to 20 of about 8,494 (234)

Using microbial metalo-aminopeptidases as targets in human infectious diseases [PDF]

open access: yesMicrobial Cell, 2021
Several microbial metalo-aminopeptidases are emerging as novel targets for the treatment of human infectious diseases. Some of them are well validated as targets and some are not; some are essential enzymes and others are important for virulence and ...
Jorge González-Bacerio   +5 more
doaj   +2 more sources

Phosphonic Acid Analogues of Phenylglycine as Inhibitors of Aminopeptidases: Comparison of Porcine Aminopeptidase N, Bovine Leucine Aminopeptidase, Tomato Acidic Leucine Aminopeptidase and Aminopeptidase from Barley Seeds [PDF]

open access: yesPharmaceuticals, 2019
The inhibitory activity of 14 racemic phosphonic acid analogs of phenylglycine, substituted in aromatic rings, towards porcine aminopeptidase N (pAPN) and barley seed aminopeptidase was determined experimentally.
Weronika Wanat   +3 more
doaj   +3 more sources

Marine Invertebrates: A Promissory Still Unexplored Source of Inhibitors of Biomedically Relevant Metallo Aminopeptidases Belonging to the M1 and M17 Families [PDF]

open access: yesMarine Drugs, 2023
Proteolytic enzymes, also known as peptidases, are critical in all living organisms. Peptidases control the cleavage, activation, turnover, and synthesis of proteins and regulate many biochemical and physiological processes.
Isel Pascual Alonso   +8 more
doaj   +2 more sources

P1′ Residue-Oriented Virtual Screening for Potent and Selective Phosphinic (Dehydro) Dipeptide Inhibitors of Metallo-Aminopeptidases

open access: yesBiomolecules, 2020
Designing side chain substituents complementary to enzyme binding pockets is of great importance in the construction of potent and selective phosphinic dipeptide inhibitors of metallo-aminopeptidases.
Michał Talma, Artur Mucha
doaj   +2 more sources

Aminopeptidases of Germinated and Non-Germinated Barley

open access: yesFood Technology and Biotechnology, 2009
In processes of barley plant development, various endo- and exopeptidases are involved. To determine the type and number of aminopeptidases that could participate in barley seed germination and tissue growth, their activities in extracts of non ...
Bojana Vukelić   +2 more
doaj   +1 more source

Aminopeptidases of malaria parasites:new targets for chemotherapy

open access: yes, 2010
Novel targets for new drug development are urgently required to combat malaria, a disease that puts half of the world's population at risk. One group of enzymes identified within the genome of the most lethal of the causative agents of malaria ...
Brown, Christopher L   +9 more
core   +5 more sources

Soil aminopeptidase activities under 145-year crop rotation and fertility practices in the North Central US

open access: yesGeoderma, 2023
Aminopeptidases catalyze the hydrolysis of peptides into constituent amino acids and are therefore a key step in nitrogen (N) depolymerization and downstream mineralization. Differences in carbon (C):N as well as sulfur (S) content of amino acids present
Jasdeep Singh   +3 more
doaj   +1 more source

Influence of bioremediation stimulators in soil on development of oat seedlings (Avena sativa) and their aminopeptidase activity / Wpływ pozostałości substancji ropopochodnych w glebie na rozwój owsa i aktywność aminopeptydazową

open access: yesArchives of Environmental Protection, 2015
Dobór technik bioremediacji jest bardzo ważny w oczyszczaniu gleby skażonej substancjami ropopochodnymi, która ma być wykorzystywanej rolniczo. Prezentowane wyniki wskazują, że na rozwój siewek owsa większy wpływ ma stosowana metoda bioremediacji niż ...
Pawełczak Małgorzata   +5 more
doaj   +1 more source

Human Aminopeptidases: A Review of the Literature [PDF]

open access: yes, 1988
Summary: The aminopeptidases constitute a group of enzymes with closely related activities. In clinical chemistry the analysis of the aminopeptidases and of their multiple forms in serum has for a long time been hindered by considerable confusion ...
G. -j. S   +5 more
core   +1 more source

Genetic characterization of the peptidases of Polistes versicolor (Hymenoptera: Vespidae) [PDF]

open access: yesBrazilian Journal of Biology, 2003
Starch gel electrophoresis with L-leucyl-beta-naphthylamide as substrate revealed five aminopeptidases in extracts of Polistes versicolor. These enzymes are presumably products of five structural gene loci.
M. A. Del Lama, K. M. Ferreira
doaj   +1 more source

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