Results 151 to 160 of about 6,032 (181)
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Porphyrin—Aminoquinoline Conjugates as Telomerase Inhibitors.
ChemInform, 2003A series of metalloporphyrins was prepared in order to target the G-quadruplex structure of telomeric DNA for the design of antitelomerase compounds. The initial cationic tetramethylpyridiniumyl porphyrin was modified by the replacement of one or two methylpyridiniumyl groups by one or two 4-aminoquinoline moieties, at the meso position, in order to ...
Alexandrine, Maraval +5 more
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8-aminoquinolines as anticoccidials - part III
Bioorganic & Medicinal Chemistry Letters, 1999Analogues of the antimalarial pentaquine, 1, in which the nature of the side-chain on the 8-amino position was varied, were prepared and evaluated for anticoccidial activity both in vitro and in vivo. Specifically, both the inter-nitrogen distance and the nature of the terminal amino group were investigated.
R E, Armer +10 more
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Efficient route to substituted 2-aminoquinoline
Chemistry of Heterocyclic Compounds, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
V. D. Dyachenko, A. G. Kudryavtseva
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Three 4-aminoquinolines of antimalarial interest
Acta Crystallographica Section C Crystal Structure Communications, 2006The structures of three compounds with potential antimalarial activity are reported. In N,N-diethyl-N'-(7-iodoquinolin-4-yl)ethane-1,2-diamine, C15H20IN3, (I), the molecules are linked into ribbons by N-H...N and C-H...N hydrogen bonds. In N-(7-bromoquinolin-4-yl)-N',N'-diethylethane-1,2-diamine dihydrate, C15H20BrN3.2H2O, (II), two aminoquinoline ...
Susan A, Bourne +2 more
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Synthesis of novel fluorinated 4-aminoquinoline derivatives
Tetrahedron Letters, 2005AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access the actual ChemInform Abstract, please click on HTML or PDF.
Maurice Medebielle +4 more
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Infrared study of the hydrogen bonding ability of 3-aminoquinoline and 8-aminoquinoline
Vibrational Spectroscopy, 1995Abstract The geometry and the complexing ability of 3-aminoquinoline (3-AQ) and 8-aminoquinoline (8-AQ) are investigated by infrared spectrometry in carbon tetrachloride solution. The study of the NH(D) stretching vibrations in partially N-deuterated 8-AQ suggests that the two NH(D) bonds are not equivalent and this is accounted for by the presence ...
N. Leroux +2 more
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8-Aminoquinolines: future role as antiprotozoal drugs
Current Opinion in Infectious Diseases, 2006This review focuses on recent developments on evaluation of 8-aminoquinoline analogs with broader efficacy and reduced toxicity, which would provide better drugs for treatment of protozoal infections.The earlier efforts towards development of 8-aminoquinoline analogs have been directed to extensive derivatization programs.
Babu L, Tekwani, Larry A, Walker
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Pharmacologic actions of 4-aminoquinoline compounds
The American Journal of Medicine, 1983The pharmacokinetics, physiologic effects, and the metabolization of chloroquine and hydroxychloroquine are all similar. Their concentrations in plasma and tissue are directly related to daily dosing. The highest concentrations are found in melanin-containing tissues, particularly the choroid and ciliary body of the eye.
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Quinolines VI. Some 4-Aminoquinoline Derivatives
Journal of the American Chemical Society, 1948E A, STECK, L L, HALLOCK, C M, SUTER
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