Results 21 to 30 of about 6,120 (213)

Catalyst controlled remote CH activation of 8-aminoquinolines with NFSI for CN versus CF coupling

Catalysis Communications, 2021
A catalyst-controlled selective functionalization of 8-aminoquinolines with N-fluorobenzenesulfonimide (NFSI) has been developed. The use of GTP-Cu catalysts leads to CN coupling products and whereas the CF coupling reaction is dominant for GPT-Ni ...
Kai Zheng, Enmu Zhou, Letian Zhang, Lixi Zhang, Wenbo Yu, Hao Xu, Chao Shen   +6 more
doaj   +1 more source

Aminoquinolines afford resistance to cerebral malaria in susceptible mice

Journal of Global Antimicrobial Resistance, 2020
Objectives: Malaria treatment is impeded by increasing resistance to conventional antimalarial drugs. Here we explored the activity of ten novel benzothiophene, thiophene and benzene aminoquinolines. Methods: In vitro testing was performed by the lactate
Jelena Srbljanović, Branko Bobić, Tijana Štajner, Aleksandra Uzelac, Igor Opsenica, Nataša Terzić-Jovanović, Neda Bauman, Bogdan A. Šolaja, Olgica Djurković-Djaković   +8 more
doaj   +1 more source

KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. [PDF]

, 2014
Preventing relapses of Plasmodium vivax malaria through a radical cure depends on use of the 8-aminoquinoline primaquine, which is associated with safety and compliance issues.
Borboa, Rachel, Campo, Brice, Chatterjee, Arnab K, Chen, Zhong, Diagana, Thierry T, Gagaring, Kerstin, Glynne, Richard J, Klooster, Els J, Kocken, Clemens HM, Kuhen, Kelli, Leroy, Didier, Luty, Adrian, McNamara, Case W, Nagle, Advait, Plouffe, David M, Remarque, Edmond J, Roland, Jason, Sauerwein, Robert, Thomas, Alan W, van Amsterdam, Sandra M, van den Berg, Alexander, van Gemert, Geert-Jan, Voorberg-van der Wel, Annemarie, Winzeler, Elizabeth A, Yeung, Bryan KS, Zeeman, Anne-Marie   +25 more
core   +1 more source

Molecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong Subregion

Malaria Journal, 2019
Background Plasmodium vivax malaria elimination can only be achieved by the deployment of 8-aminoquinolines (primaquine and tafenoquine) in combination with ACT to kill both blood and liver-stage parasites.
Germana Bancone, Didier Menard, Nimol Khim, Saorin Kim, Lydie Canier, Chea Nguong, Koukeo Phommasone, Mayfong Mayxay, Sabine Dittrich, Malavanh Vongsouvath, Nadine Fievet, Jean-Yves Le Hesran, Valerie Briand, Sommay Keomany, Paul N. Newton, Gornpan Gorsawun, Kaelan Tardy, Cindy S. Chu, Orpreeya Rattanapalroj, Le Thanh Dong, Huynh Hong Quang, Nguyen Tam-Uyen, Nguyen Thuy-Nhien, Tran Tinh Hien, Michael Kalnoky, Francois Nosten   +25 more
doaj   +1 more source

Putative Contribution of 8-Aminoquinolines to Preventing Recrudescence of Malaria

Tropical Medicine and Infectious Disease, 2023
Enhanced therapeutic efficacy achieved in treating Plasmodium vivax malaria with an 8-aminoquinoline (8-AQ) drug such as primaquine (PQ) together with a partner drug such as chloroquine (CQ) is usually explained as CQ inhibiting asexual parasites in the ...
Miles B. Markus
doaj   +1 more source

Synthesis and Antimycobacterial Evaluation of N-(4-(Benzyloxy)benzyl)-4-aminoquinolines

Molecules, 2022
Tuberculosis remains a global health problem that affects millions of people around the world. Despite recent efforts in drug development, new alternatives are required.
Estevão Silveira Grams, Alessandro Silva Ramos, Mauro Neves Muniz, Raoní S. Rambo, Marcia Alberton Perelló, Nathalia Sperotto, Laura Calle González, Lovaine Silva Duarte, Luiza Galina, Adilio Silva Dadda, Guilherme Arraché Gonçalves, Cristiano Valim Bizarro, Luiz Augusto Basso, Pablo Machado   +13 more
doaj   +1 more source

Cu(II) and Fe(III) complexes of sulphadoxine mixed with pyramethamine: Synthesis, characterization, antimicrobial and toxicology study [PDF]

, 2012
Two new mixed ligands metal complexes of sulphadoxine and pyramethamine were prepared by using CuCl2.6H2O and FeCl3.6H2O. The complexes were characterized by elemental analysis, melting point determination, molar conductivity, metal content analysis (AAS)
Adekoya, J. A., Ajanaku, K. O., Ajani, O. O., Ehi-Eromosele, C. O., Obaleye, J. A., Ogunniran, K. O.   +5 more
core   +4 more sources

Primaquine for Plasmodium vivax radical cure: What we do not know and why it matters

International Journal for Parasitology: Drugs and Drug Resistance, 2021
Plasmodium vivax radical cure requires the administration of a blood schizonticide for killing blood-stage parasites and the addition of a drug able to kill hypnozoites, the dormant parasite stages residing in the liver of infected patients.
Jean Popovici, Kieran Tebben, Benoit Witkowski, David Serre   +3 more
doaj   +1 more source

A first example of cobalt-catalyzed remote C-H functionalization of 8-aminoquinolines operating through a single electron transfer mechanism [PDF]

, 2016
The development of new C[BOND]H functionalization protocols based on inexpensive cobalt catalysts is currently attracting significant interest. Functionalized 8-aminoquinoline compounds are high-potential building blocks in organic chemistry and ...
Ackermann, Cong, Corbet, Donaldson, Dong, Fors, Galliker, Gandy, Goldstein, Grossi, Guo, Guo, He, Hong, Hu, Iwai, Katayev, Kilpatrick, Kochi, Koley, Liang, Liu, Liu, Maity, Moselage, Nakata, Olah, Ono, Planas, Qiao, Recht, Sahoo, Saito, Seuss, Taniguchi, Wang, Wei, Wei, Williams, Xia, Xu, Yan, Yan, Yoon, Zhang, Zhang, Zhang, Zhao, Zhou, Zhu   +49 more
core   +1 more source

Primaquine-induced haemolysis in females heterozygous for G6PD deficiency

Malaria Journal, 2018
Oxidative agents can cause acute haemolytic anaemia in persons with G6PD deficiency. Understanding the relationship between G6PD genotype and the phenotypic expression of the enzyme deficiency is necessary so that severe haemolysis can be avoided.
Cindy S. Chu, Germana Bancone, François Nosten, Nicholas J. White, Lucio Luzzatto   +4 more
doaj   +1 more source