Results 31 to 40 of about 6,120 (213)

Intermittent preventive treatment with dihydroartemisinin-piperaquine in Ugandan schoolchildren selects for Plasmodium falciparum transporter polymorphisms that modify drug sensitivity. [PDF]

, 2016
Dihydroartemisinin-piperaquine (DP) offers prolonged protection against malaria, but its impact on Plasmodium falciparum drug sensitivity is uncertain. In a trial of intermittent preventive treatment in schoolchildren in Tororo, Uganda, in 2011 to 2012 ...
Brooker, SJ, Conrad, MD, Dorsey, G, Kamya, MR, Legac, J, Nankabirwa, JI, Nsobya, SL, Rosenthal, PJ, Staedke, SG, Tukwasibwe, S, Tumwebaze, P, Wandera, B   +11 more
core   +3 more sources

Review of mass drug administration for malaria and its operational challenges. [PDF]

, 2015
Mass drug administration (MDA) was a component of many malaria programs during the eradication era, but later was seldomly deployed due to concerns regarding efficacy and feasibility and fear of accelerating drug resistance.
Chen, Ingrid, Gosling, Roly, Greenwood, Brian, Hwang, Jimee, Ippolito, Matthew M, Kachur, S Patrick, Koita, Kadiatou, Newby, Gretchen, Poirot, Eugenie, Shanks, G Dennis, Slutsker, Laurence, von Seidlein, Lorenz, Wegbreit, Jennifer   +12 more
core   +1 more source

Hybrids of 4-aminoquinolines and adamantane as inhibitors of AChE [PDF]

Journal of the Serbian Chemical Society
Alzheimer’s disease (AD) is an incurable and progressive neurodegenerative disorder that causes cognitive capabilities and memory loss and damage to brain functionality and structure.
Komatović Katarina, Matošević Ana, Zlatović Mario, Sladić Dušan, Bosak Anita, Opsenica Dejan M.   +5 more
doaj   +1 more source

Changing antimalarial drug resistance patterns identified by surveillance at three sites in Uganda. [PDF]

, 2016
: We assessed Plasmodium falciparum drug resistance markers in parasites collected in 2012, 2013, and 2015 at 3 sites in Uganda. The prevalence and frequency of parasites with mutations in putative transporters previously associated with resistance to ...
Asua, V, Conrad, M, Dorsey, G, Greenhouse, B, Kamya, MR, Nankabirwa, J, Nsobya, SL, Rosenthal, PJ, Ruhamyankaka, E, Staedke, SG, Taylor, A, Tukwasibwe, S, Tumwebaze, P, Walakira, A, Yeka, A   +14 more
core   +2 more sources

Immune Modulation as a Therapeutic Option During the SARS-CoV-2 Outbreak: The Case for Antimalarial Aminoquinolines

Frontiers in Immunology, 2020
The rapid spread, severity, and lack of specific treatment for COVID-19 resulted in hasty drug repurposing. Conceptually, trials of antivirals were well-accepted, but twentieth century antimalarials sparked an impassioned global debate.
Joana Vitte, Joana Vitte, Moïse Michel, Moïse Michel, Soraya Mezouar, Soraya Mezouar, Aïssatou Bailo Diallo, Aïssatou Bailo Diallo, Asma Boumaza, Asma Boumaza, Jean-Louis Mege, Jean-Louis Mege, Benoit Desnues, Benoit Desnues   +13 more
doaj   +1 more source

Cobalt-Promoted Dimerization of Aminoquinoline Benzamides [PDF]

Organic Letters, 2015
A method for aminoquinoline-directed, cobalt-promoted dimerization of benzamides has been developed. Reactions proceed in ethanol solvent in the presence of Mn(OAc)2 cocatalyst and Na2CO3 base and use oxygen as a terminal oxidant. Bromo, iodo, nitro, ether, and ester moieties are compatible with the reaction conditions. Cross-coupling of electronically
Liene, Grigorjeva, Olafs, Daugulis
openaire   +2 more sources

The Use of Antimalarial Drugs against Viral Infection

Microorganisms, 2020
In recent decades, drugs used to treat malaria infection have been shown to be beneficial for many other diseases, including viral infections. In particular, they have received special attention due to the lack of effective antiviral drugs against new ...
Sarah D’Alessandro, Diletta Scaccabarozzi, Lucia Signorini, Federica Perego, Denise P. Ilboudo, Pasquale Ferrante, Serena Delbue   +6 more
doaj   +1 more source

Genotype-phenotype association and biochemical analyses of glucose-6-phosphate dehydrogenase variants: Implications for the hemolytic risk of using 8-aminoquinolines for radical cure

Frontiers in Pharmacology, 2022
Background:Plasmodium vivax remains the malaria species posing a major threat to human health worldwide owing to its relapse mechanism. Currently, the only drugs of choice for radical cure are the 8-aminoquinolines (primaquine and tafenoquine), which are
Sirapapha Sudsumrit, Kamonwan Chamchoy, Duantida Songdej, Poom Adisakwattana, Srivicha Krudsood, Emily R. Adams, Mallika Imwong, Ubolsree Leartsakulpanich, Usa Boonyuen   +8 more
doaj   +1 more source

Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones [PDF]

, 2008
A series of primaquine-derived imidazolidin-4-ones were screened for their in vitro activity against Pneumocystis carinii and Plasmodium falciparum W2 strain. Most compounds were active against P.
Jiri Gut, Margaret S Collins, Melanie T Cushionc, Nuno Vale, Paula Gomes, Philip J Rosenthal, Ricardo Ferraz, Rui Moreira   +7 more
core   +1 more source

Glucose-6-phosphate dehydrogenase activity measured by spectrophotometry and associated genetic variants from the Oromiya zone, Ethiopia

Malaria Journal, 2018
Background The study aimed to gain first data on the prevalence of G6PD enzyme deficiency measured by spectrophotometry and associated genetic variants in Jimma and surroundings, Ethiopia.
Nora Kießling, Joaquin Brintrup, Ahmed Zeynudin, Nuredin Abduselam, Sylvia Götz, Margith Mack, Michael Pritsch, Andreas Wieser, Elisabeth Kohne, Nicole Berens-Riha   +9 more
doaj   +1 more source