Results 41 to 50 of about 4,665 (160)

Inflammatory Bowel Disease: Mechanisms and Therapeutic Advances

MedComm, Volume 7, Issue 9, September 2026.
Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is a rising, multifactorial chronic disorder driven by dysregulated mucosal immunity in genetically susceptible individuals and influenced by environmental and microbial factors.
Andrea Papait, Anna Cargnoni, Franco Scaldaferri, Loris Lopetuso, Antonietta Rosa Silini, Ornella Parolini   +5 more
wiley   +1 more source

The Mycobacterium tuberculosis Rv0132c Gene Product Mtb‐FGD2 Can Act as an F420‐Dependent Glucose Dehydrogenase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 9, Page 1610-1627, September 2026.
ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi, Matthew Snee, Richard B. Tunnicliffe, Linus O. Johanissen, Matthew J. Cliff, Colin W. Levy, Derren J. Heyes, Marina Golovanova, Thomas A. Jowitt, Sam Hay, Andrew W. Munro, Jonathan P. Waltho, David Leys   +12 more
wiley   +1 more source

Beyond Glucocorticoids: The Current Landscape and Prospects for Treating Immune Checkpoint Inhibitor‐Induced Autoimmunity

ACR Open Rheumatology, Volume 8, Issue 8, August 2026.
The rapid integration of immune checkpoint inhibitors (ICIs) into standard oncology protocols has birthed a new frontier in clinical rheumatology: immune‐related adverse events (irAEs). By disrupting the programmed cell death‐1 (PD‐1)/PD‐L1 and cytotoxic T‐lymphocyte‐associated protein 4 (CTLA‐4) axes to restore antitumor T cell activity, these ...
Xizi Hu, Ji Eun Ryoo, Brian S. Henick, Adam Mor   +3 more
wiley   +1 more source

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, Volume 13, Issue 44, 7 August 2026.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

Protective effects of Graptophyllum pictum extract and its impact on the regulation of inflammatory mediators and short-chain fatty acids in experimental models: a multi-parameter comparative study

Frontiers in Veterinary Science
BackgroundPersistent colonic inflammation disrupts epithelial integrity, alters microbial metabolites, and impairs gut function. Graptophyllum pictum (daun wungu) contains bioactive compounds with anti-inflammatory and mucosal-protective potential, but ...
Sigit Adi Prasetyo, Endang Sri Lestari, Ignatius Riwanto, Bernardus Parish Budiono, Agung Aji Prasetyo, Bernardus Widodo Subagio, Rinaldi Hartanto, Hendry Lie, Kenny Wijaya Sutanto   +8 more
doaj   +1 more source

Severe Ulcerative Colitis With Cytomegalovirus Colitis Treated by Early Surgery: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Acute severe ulcerative colitis complicated by cytomegalovirus infection requires individualized management, and timely surgical intervention should be considered in carefully selected high‐risk patients who are unlikely to benefit from further medical therapy.
Hiroyuki Fujimura, Atsushi Goto, Takenaka Kazuyuki, Hiroshi Itoh, Taro Takami   +4 more
wiley   +1 more source

Oral Health of Patients With Inflammatory Bowel Disease—A Cross‐Sectional Survey in Austria

Clinical and Experimental Dental Research, Volume 12, Issue 4, August 2026.
ABSTRACT Objective This cross‐sectional survey aimed to assess oral health in patients with inflammatory bowel diseases (IBD) living in Austria. Methods Data collection was conducted with an online questionnaire, including when possible validated tools, covering general medical history, socioeconomic factors, IBD‐related parameters, and various oral ...
Kristina Bertl, Arghavan Yari, Anna Riener, Johan Burisch, Nikolaos Pandis, Hady Haririan, Andreas Stavropoulos   +6 more
wiley   +1 more source

Discovery of N-sulfonylated aminosalicylic acids as dual MCL-1/BCL-xL inhibitors. [PDF]

RSC Med Chem, 2023
Chen L, Chauhan J, Yap JL, Goodis CC, Wilder PT, Fletcher S.   +5 more
europepmc   +1 more source

Cod Skin Collagen Peptides Alleviate Ulcerative Colitis by Regulating Gut Microbiota to Inhibit NLRP3 Inflammasome Activation

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
CP suppresses NLRP3 inflammasome activation through modulation of the gut microbiota, thereby exerting protective effects against ulcerative colitis. ABSTRACT Enteral nutrition is an important intervention for ulcerative colitis, and collagen can improve immune responses and repair the intestinal barrier.
Longyi Piao, Jiaqi Huo, Yanru Dong, Shuxia Cao, Xiangdan Li, Dongyuan Xu, Xianglan Li, Lan Liu   +7 more
wiley   +1 more source

Rehmannia glutinosa Extracts Enhances Ketone Bodies Expression and Alleviates Ulcerative Colitis as A Novel Ketogenic Functional Food

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Rehmannia glutinosa (DH) can act as a novel ketogenic functional food to enhance the expression of ketone bodies without altering the normal dietary structure. This effect might be attributed to the increased activity of key enzymes involved in ketogenesis, such as 3‐hydroxybutyrate dehydrogenase 1 (BDH1) and 3‐hydroxymethylglutaryl‐CoA synthase 2 ...
Yiqiao Gao, Simiao Wang, Yuye Yang, Wei Tang, Jianhan Zhen, Xiangshi Song   +5 more
wiley   +1 more source